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J. Jean Cui, PhD, tells the tale of the cancer therapeutic Xalkori. (Photo by Cristy Lytal)

Pfizer’s J. Jean Cui explains modern drug discovery

Only five percent of potential cancer drugs make it from phase I clinical trail to FDA approval, but J. Jean Cui, PhD, associate research fellow at Pfizer, beat the odds. Cui visited …

Embryonic stem cells (Image/courtesy of Qi-Long Ying)

USC researcher reveals how to better master stem cells’ fate

USC scientist Qi-Long Ying and a team of researchers have long been searching for biotech’s version of the fountain of youth — ways to encourage embryonic stem cells (ESCs) and epiblast stem …

Judy Villablanca (Photo courtesy of Children's Hospital Los Angeles)

Magnetic treatment for high-risk neuroblastoma proves less than attractive

Removing tumor cells with a magnet? It may sound strange, but researchers at Children’s Hospital Los Angeles (CHLA) and their colleagues recently explored whether this technique can create better outcomes for patients …

Speakers at the first first Zilkha Mini­Symposium on Alzheimer’s Research at USC covered a variety of topics on the devastating disease. Pictured here (left to right) are Christian Pike, PhD, associate professor, USC Davis School of Gerontology; Hong-Wei Dong, MD, PhD, associate professor, department of neurology; Roberta Brinton, PhD, R. Pete Vanderveen Chair in Therapeutic Discovery & Development; Maria Carrillo, vice president, medical and scientific relations, Alzheimer’s Association; Russell Jacobs, PhD, member, Zilkha Neurogenetic Institute; Arthur W. Toga, PhD, Provost Professor of Ophthalmology, Neurology, Psychiatry and the Behavioral Sciences, Radiology and Engineering; director of the USC Institute for Neuroimaging and Informatics; Paul Thompson, PhD, professor of ophthalmology, neurology, psychiatry and the behavioral sciences, radiology and engineering; Helena Chui, MD, Raymond and Betty McCarron Chair in Neurology; Lon Schneider, MD, director, USC Alzheimer Disease Research and Clinical Center; Berislav Zlokovic, MD, PhD, director, Zilkha Neurogenetic Institute; and Scott Fraser, PhD, Provost Professor of Biological Sciences and Biomedical Engineering. (Photo by Amy E. Hamaker)

First Zilkha Alzheimer’s Mini-Symposium examines vascular system connections

Alzheimer’s disease is the sixth leading cause of death in the United States, and more than five million Americans live with the disease, according to the Alzheimer’s Association. Conquering Alzheimer’s was the …

From left, Andrew P. McMahon, director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, with Yong Chen’s son Gary and researcher Qi-Long Ying (Photo by Cristy Lytal)

Businessman invests in stem cell research at USC

Chinese businessman Yong Chen has pledged $1 million to USC stem cell researcher Qi-Long Ying to support his future “eureka moments.” “When I talked to Mr. Chen, I told him that groundbreaking …

Neural stem cells derived from self-renewing mouse embryonic stem cells (Image courtesy of Qi-Long Ying)

A special protein helps embryonic stem cells keep their options open

In the ongoing quest to understand how embryonic stem cells (ESCs) retain their ability to differentiate into virtually any kind of cell, USC faculty member Qi-Long Ying and a team of researchers …

From left, Gage Crump, Jay R. Lieberman and Francesca Mariani (Photo by Cristy Lytal)

USC announces winners of first Regenerative Medicine Initiative awards

Three newly assembled disease teams within USC Stem Cell will take the early steps this year that might lead to future stem-cell based therapies for certain forms of deafness, bone defects and …

Qi-Long Ying (Photo by Cristy Lytal)

A genetic catch-22 promotes and prevents liver cancer

Can the same gene prevent and promote cancer? When it comes to liver cancer, the gene that codes for P53, a protein found in humans and many other animals, involves this catch-22. …

Wange Lu (Photo by Chris Shinn)

USC study sheds light on stem cell reprogramming

Researchers are learning how to turn regular cells into stem cells, a process called reprogramming. However, some of the mechanisms of the process remain unknown, such as why only a small proportion of the cells can be reprogrammed. Researchers have at least part of the answer: the structure of genes.

Norman Arnheim

Common genetic disease linked to father’s age

Scientists at USC have unlocked the mystery of why new cases of the genetic disease Noonan syndrome are so common—a mutation, which causes the disease, disproportionately increases a normal father’s production of …

Songtao Shi, DDS, PhD (Photo courtesy of the Ostrow School of Dentistry of USC)

New method to treat chemo-related jaw bone necrosis

Over the last decade, osteonecrosis of the jaw (ONJ) has emerged as a devastating and debilitating condition of cancer patients receiving high doses of antiresorptive chemotherapy (bisphosphonates and denosumab). ONJ currently has …

From left to right: Mr. K.V. Kumar, Dr. Andy McMahon, Sir John Gurdon and Mr. Jonathan Thomas (Photo courtesy of USC)

Interview with Sir John Gurdon

Sir John Gurdon, a Nobel Prize-winning biologist whose experiments in the field of cloning laid the foundation for modern stem cell research, visited the USC Health Sciences Campus on May 16. He …

Sir John Gurdon won the 2012 Nobel Prize in Physiology or Medicine for laying the groundwork for stem cell research. (Photo courtesy of John Gurdon)

Nobel Laureate discusses history of cloning

Cells can be stubborn things. A skin cell resists changing into a liver cell, and a heart cell wants to remain a heart cell. But with the right kind of manipulation, they …

Sir John Gurdon won the 2012 Nobel Prize in Physiology or Medicine for laying the groundwork for stem cell research. (Photo courtesy of John Gurdon)

Nobel laureate to speak on stem cells at HSC

Nobel laureate Sir John Gurdon will speak on “From Nuclear Transplantation to Prospects for Cell Replacement” on May 16 at noon in the Aresty Auditorium of the Harlyne J. Norris Cancer Research …

Andy McMahon (Photo by Phil Channing)

Probing the power of stem cells

Piece by missing piece, scientists at the Keck School of Medicine of USC are deciphering the powerful gene regulatory circuit that maintains and controls the potential of embryonic stem cells (ESCs) to …

Dr. Wange Lu and Fan Gao (Photo courtesy of USC)

Unraveling the mystery of pluripotency in embryonic stem cells

Using advanced sequencing technology, USC Stem Cell faculty member Wange Lu, in collaboration with Kai Wang of the USC Zilkha Neurogenetics Institute, explores the mystery of pluripotency by mapping out the interaction …

Cancer cells (Image courtesy of Creative Commons)

USC scientists contribute to international research on genetic risks for cancer

Researchers from the USC Norris Comprehensive Cancer Center are joining hundreds of scientists worldwide in reporting the discovery of more than 80 new regions of the human genome that indicate risk for …

The cover image of Aging Cell shows a common type of genetic damage to a cell when breaks occur in both strands of DNA. (Photo courtesy of Aging Cell)

USC researchers show increase of cell mutations with age

Like an old car that gradually rusts as it ages, even if there is no lethal damage to a critical part of the car, a human body accumulates genetic damage as it …

Andy McMahon (Photo by Phil Channing)

McMahon discusses central role of stem cell biology in medicine of the future

USC scored a major coup when it brought scientist Andrew McMahon to the Keck School of Medicine of USC from Harvard University, where he had served for almost two decades as a …

Dr. Qilong Ying (left) and USC graduate student Chih-I (Jimmy) Tai (Photo courtesy of USC)

An important factor identified in reprogramming

How is the stem cell state programmed? A new study in Qi-Long Ying’s group at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC highlights the role …