Overview

USC Stem Cell scientists are advancing our understanding of how the body develops, maintains and repairs the brain, nerves and senses. They are using stem cells to find new regenerative therapies for conditions including Alzheimer’s disease, neurodegenerative diseases, brain tumors, hearing loss and vision loss.

Statistics

  • Alzheimer’s disease is the sixth leading cause of death in the US. An estimated 5.5 million Americans are living with Alzheimer’s disease.
  • ALS, or Lou Gehrig’s disease, causes progressive paralysis and usually results in fatal respiratory failure within three to five years of diagnosis.
  • Brain tumors are the most common cancer and leading cause of cancer-related death in children fourteen years and younger.
  • Twenty percent of Americans—or 48 million people—report some degree of hearing loss.
  • More than 20 million Americans report some degree of vision loss.

Researchers

Brain, Nerves and Senses News

A gene control element for human outer ear development shows activity in the gills (green) of a 2-week old zebrafish (Image by Mathi Thiruppathy/Crump Lab/USC Stem Cell)

An earful of gill: USC Stem Cell study points to the evolutionary origin of the mammalian outer ear

The outer ear is unique to mammals, but its evolutionary origin has remained a mystery. According to a new study published in Nature from the USC Stem Cell lab of Gage Crump, …

In the zebrafish inner ear, a cell type known as supporting cells (magenta) gives rise to new sensory hearing cells (blue). The study reveals a set of DNA control elements critical for supporting cells to regenerate hair cells after injury in zebrafish, lizards and other regenerative species. (Image by Tuo Shi/Crump and Lozito labs/USC Stem Cell)

USC Stem Cell study breaks the silence on how fish and lizards regenerate hearing

A new USC Stem Cell study published in the Proceedings of the National Academy of Sciences (PNAS) has identified key gene regulators that enable some deafened animals—including fish and lizards—to naturally regenerate …

Newborn neuron (green and purple cell) in brain tissue from patients with epilepsy (Image by Aswathy Ammothumkandy/Bonaguidi Lab/USC Stem Cell)

To remember conversations, keep making new brain cells

USC-led study of patients with epilepsy shows how making new neurons benefits cognition in adults. Why do adults make new brain cells? A new study published in Cell Stem Cell provides the …

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Brain, Nerves and Senses Videos

Dr. Justin Ichida’s research focuses on how genetic and environmental factors contribute to human neurodegenerative disease. His laboratory uses cellular reprogramming and stem cell technology to build patient-specific in vitro models of neurodegenerative disease, enabling the screening of drug-like compounds in search of potential therapeutics. To learn more, visit https://ichidalab.usc.edu.
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