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Dr. Mariani’s laboratory studies the development and repair of the mammalian skeleton, with an emphasis on the ribs and handplate. They use standard and conditional knock-out techniques in mouse models and mouse embryonic stem (ES) cells.

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From left, Gage Crump, Jay R. Lieberman and Francesca Mariani (Photo by Cristy Lytal); featured image for Bone defects inspire perfect union between surgeon-scientist and stem cell researchers at USC

Bone defects inspire perfect union between surgeon-scientist and stem cell researchers at USC

As chair of the Department of Orthopaedic Surgery at the Keck School of Medicine of USC, Jay R. Lieberman regularly sees patients with bone defects too severe to heal. This unmet clinical …

Francesca Mariani (Photo by Chris Shinn); featured image for What I’m reading: Top pick from stem cell faculty member Francesca Mariani

What I’m reading: Top pick from stem cell faculty member Francesca Mariani

In a recent study in the journal Cell, Kyle Loh and colleagues in Irving Weissman’s group established a rapid protocol for converting human pluripotent stem cells into mesoderm—the progenitors for heart, skeleton, …

Stem cells self-organize to form a hollow ball of cells. (Image by In Kyoung Mah and Francesca Mariani); featured image for A gene called Prkci helps organize organisms and their organs

A gene called Prkci helps organize organisms and their organs

A gene called Prkci can point cells in the right direction, according to a new study in Developmental Biology. In the study, USC Stem Cell researcher In Kyoung Mah from the laboratory …

New ways to regenerate bone emerge from the adult zebrafish face. (Image by Sandeep Paul and Seth Ruffins); featured image for USC Stem Cell researchers use zebrafish to understand the role of cartilage in bone repair

USC Stem Cell researchers use zebrafish to understand the role of cartilage in bone repair

Scientists have long believed that the processes required for embryonic development are recapitulated during the regeneration of damaged body parts, such as fractured bones. In a new study published in Development, USC …

The gene Prkci promotes the generation of differentiated cells (red). However if Prkci activity is reduced or absent, neural stem cells (green) are promoted. (Image by In Kyoung Mah); featured image for A Prkci gene keeps stem cells in check

A Prkci gene keeps stem cells in check

When it comes to stem cells, too much of a good thing isn’t wonderful: producing too many new stem cells may lead to cancer; producing too few inhibits the repair and maintenance …

USC graduate student Du Jiang (Photo by Cristy Lytal); featured image for Tri-institutional Stem Cell Retreat brings together Broad centers from USC, UCLA and UCSF

Tri-institutional Stem Cell Retreat brings together Broad centers from USC, UCLA and UCSF

Working alone, a scientist or university can only make so much progress in finding answers to basic questions or new treatments for diseases ranging from HIV to cancer to diabetes. That’s why …

“Tin Woman” Michaela Patterson, a postdoctoral scholar in the lab of Henry Sucov, studies heart regeneration — with no help from the Wizard of Oz. (Photo by Cristy Lytal); featured image for Halloween retreat showcases USC’s “scary smart” stem cell researchers

Halloween retreat showcases USC’s “scary smart” stem cell researchers

It was no tricks and all treats at the seventh annual retreat for the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, held at the university’s …

Mouse rib cage stained to show cartilage (blue) and bone (red). In adult mice, surgically removed sections of either portion can fully regenerate. (Image by Francesca Mariani); featured image for USC researchers discover the healing power of “rib tickling”

USC researchers discover the healing power of “rib tickling”

Unlike salamanders, mammals can’t regenerate lost limbs, but they can repair large sections of their ribs. In a new study in the Journal of Bone and Mineral Research, a team directed by …

Multi-well plate (Image courtesy of the National Institutes of Health); featured image for USC Stem Cell and the USC Norris Comprehensive Cancer Center accelerate drug discovery

USC Stem Cell and the USC Norris Comprehensive Cancer Center accelerate drug discovery

Three teams of USC stem cell researchers have won a coveted prize — the opportunity to test 3,000 drug candidates or chemicals for the potential to help patients. Two teams will focus …

Keynote speaker Clive Svendsen (right) and Director Andy McMahon; featured image for A Retreat from everything but stem cells

A Retreat from everything but stem cells

It wasn’t the pristine 27-hole course that drew more than 120 stem cell researchers from USC and beyond to the Desert Princess Golf Resort near Palm Springs. It was the sixth annual …

Embryonic stem cells that have differentiated into neurons (Image by In Kyoung Mah/Mariani Lab); featured image for Winner of the September 2013 USC Stem Cell Image of the Month Contest

Winner of the September 2013 USC Stem Cell Image of the Month Contest

Dr. Andrew McMahon, Dr. Seth Ruffins and the judges of the USC Stem Cell Image of the Month contest would like to congratulate our September 2013 winner, In Kyoung Mah, a graduate …

From left, Gage Crump, Jay R. Lieberman and Francesca Mariani (Photo by Cristy Lytal); featured image for USC announces winners of first Regenerative Medicine Initiative awards

USC announces winners of first Regenerative Medicine Initiative awards

Three newly assembled disease teams within USC Stem Cell will take the early steps this year that might lead to future stem-cell based therapies for certain forms of deafness, bone defects and …