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Overview

USC Stem Cell scientists are advancing our understanding of how the body develops, maintains and repairs its digestive and metabolic systems, including the liver, pancreas and digestive tract. They are also developing new regenerative treatments for patients with diabetes, metabolic syndromes, inflammatory bowel diseases, short bowel syndrome, hepatitis, liver fibrosis, liver cancer, colon cancer and many other diseases.

Statistics

  • Nearly 10 percent of Americans—more than 30 million people—have diabetes, which is the seventh leading cause of death in the US.
  • Inflammatory bowel diseases, including ulcerative colitis and Crohn’s disease, affect 1.6 million Americans.
  • Approximately 4.3 percent of people will be diagnosed with colorectal cancer in their lifetimes. Colorectal cancer affects more than 1.3 Americans, and is the second leading cause of cancer-related death in the US.
  • More than 40,000 Americans are diagnosed with liver cancer each year. Nearly 30,000 Americans die from liver cancer each year.
  • Worldwide, 500 million people have hepatitis B or C. These viruses kill 1.5 million people a year.

Researchers

News

Students

California’s stem cell agency awards USC $5 million to train scientists and clinicians

USC has been awarded a $5 million training grant from the California Institute for Regenerative Medicine (CIRM) to prepare PhD students, postdoctoral researchers, and clinical fellows for careers in stem cell research. CIRM also approved 17 other training programs at universities and clinical facilities across California, including one at USC-affiliated Children’s Hospital Los Angeles (CHLA). …

Impromptu McMahon lab meeting

USC Stem Cell: An incubator for medicine of the 21st century

Just over a decade ago, USC was a university with a few scattered stem cell biologists, and a vision for total transformation. The university was committed to designing a unique “incubator” for researchers at the Keck School of Medicine of USC and beyond to collaborate and leverage the transformative power of stem cells to develop …

Illustration by Jonathan Haase

Cycles of a fasting-mimicking diet help mice live longer, healthier

While many diets have been studied for effectiveness in preventing obesity and heart disease in both mice and humans, research on the effects and benefits of short, periodic cycles of fasting on obesity and heart health are lacking. In a new USC study on the health effects of a low-calorie diet that mimics fasting in the body, researchers found regular five-day cycles of the diet in mice seemed to counteract the detrimental effects of their usual high-fat, high-calorie diet. The study, published today in Nature Metabolism, analyzed the diet, health and lifespan …

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The University of Southern California has designed a unique “incubator” for scientists, engineers and clinicians to collaborate across disciplines and leverage the transformative power of stem cells to develop the future of regenerative medicine. The USC Stem Cell incubator trains the next generation of scientists through a dedicated PhD program and first-of-its-kind master’s degree, and brings together leading researchers from around the world to gain insights into developmental biology and advance new treatments for human disease. Learn more at http://stemcell.keck.usc.edu.
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