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Andy McMahon (Photo by Phil Channing); featured image for USC Stem Cell scientist Andy McMahon and collaborators tune into the organ concert

USC Stem Cell scientist Andy McMahon and collaborators tune into the organ concert

Every minute of every day, your organs are using a complex language to communicate with each other about the basic physiological processes necessary for life—everything from blood pressure regulation to pH balance …

Kidney (Image by Lori O'Brien/Andy McMahon Lab, illustration by Mira Nameth)

Growing hope: New organs? Not yet, but stem cell research is getting closer

If you lose a limb, it’s lost for life. If you damage a kidney, you won’t grow a new one. And if you have a heart attack, the scars are there to …

Tubular networks developing in a mammalian kidney (Image by Tracy Tran/Andy McMahon Lab); featured image for Growing hope: What are stem cells, and how does USC use them?

Growing hope: What are stem cells, and how does USC use them?

Stem cell therapies have accelerated at a promising pace, but how do they work? And what are stem cells?

Baby Jasmine was born in late December with hypoplastic left heart syndrome (HLHS) and had her first open-heart surgery at five days old. She is enrolled in the groundbreaking clinical trial at Children’s Hospital Los Angeles. (Photo courtesy of CHLA); featured image for Children’s Hospital Los Angeles joins national consortium to study use of stem cells in treating a rare cardiac defect

Children’s Hospital Los Angeles joins national consortium to study use of stem cells in treating a rare cardiac defect

Children’s Hospital Los Angeles is announcing participation in the first-ever clinical trial using stem cells from umbilical cord blood to delay or even prevent heart failure in children born with a rare …

Susana Cavallero (Photo by Cristy Lytal); featured image for USC scientist Susana Cavallero dedicates her heart to vascular stem cell research

USC scientist Susana Cavallero dedicates her heart to vascular stem cell research

Pursuing her passion for cardiovascular research, Susana Cavallero has journeyed from her hometown of Polvaredas in Saladillo, Argentina, to Buenos Aires to Los Angeles, where she is an assistant professor of research …

Michaela Patterson (Photo by Cristy Lytal); featured image for Broad Fellows look to stem cells to treat heart disease and hearing loss

Broad Fellows look to stem cells to treat heart disease and hearing loss

When it came time to select this year’s Broad Fellow, the award committee couldn’t pick just one. Instead, they bestowed the honor on two talented postdoctoral researchers in USC Stem Cell laboratories: …

Joycelyn Yip says she wishes she could have five different careers. (Photo by Susanica Tam); featured image for Creating new heart muscle out of stem cells? This grad student is doing it

Creating new heart muscle out of stem cells? This grad student is doing it

In a narrow room not much larger than a closet, Joycelyn Yip reaches behind a glass shield to lower a pipette to a plate of silicon-coated glass. Swaddled in a sterile white …

Heart muscle cells (red) with nuclei (blue). On the far right is a regenerative cell, which only has one nucleus, called a mononuclear diploid cardiomyocyte. (Image by Michaela Patterson); featured image for USC Stem Cell discovery refreshes the heart

USC Stem Cell discovery refreshes the heart

Some people are better than others at recovering from a wounded heart, according to a new USC Stem Cell study published in Nature Genetics. In the study, first author Michaela Patterson, a …

Michaela Patterson (Photo by Cristy Lytal); featured image for Meet Postdoc Michaela Patterson, presenter at the ISSCR 2017 Annual Meeting

Meet Postdoc Michaela Patterson, presenter at the ISSCR 2017 Annual Meeting

What’s the cure for a broken heart? Ask Michaela Patterson, a postdoctoral scholar in the USC Stem Cell laboratory of Henry Sucov. Patterson will deliver a presentation about heart regeneration at the …

Clockwise from top left: Andy McMahon, Rohit Varma, Jonathan Samet and Donna Spruijt-Metz (Photos courtesy of USC); featured image for NIH funding helps Americans live longer and healthier

NIH funding helps Americans live longer and healthier

The nation’s medical research agency, the National Institutes of Health, funds research to help Americans live longer and healthier. Some 148 Nobel Prize winners have received support from the NIH, demonstrating how …

Megan McCain (Photo by Will Taylor); featured image for Megan McCain appointed to Chonette Early Career Chair

Megan McCain appointed to Chonette Early Career Chair

Megan McCain, assistant professor of biomedical engineering, and stem cell biology and regenerative medicine, has been honored with the Chonette Early Career Chair at the USC Viterbi School of Engineering. As an …

Zebrafish heart with coronary vessels (Image courtesy of Ellen Lien/Children's Hospital Los Angeles)

Ching-Ling (Ellen) Lien awarded $1.7 million to study heart regeneration

Ching-Ling (Ellen) Lien, an investigator at The Saban Research Institute of Children’s Hospital Los Angeles (CHLA) and principal investigator with USC Stem Cell, has been awarded nearly $1.7 million, over a four …

Jian Xu (Photo courtesy of the Ostrow School of Dentistry of USC); featured image for Researcher Jian Xu earns accolades for cell fate studies

Researcher Jian Xu earns accolades for cell fate studies

Basic science can often be far from basic—especially for Jian Xu, who believes cells are kind of like people. “In simple terms, we look at how cells determine their own fate,” said …

Valter Longo (Photo by Dietmar Quistorf); featured image for Scientifically-designed fasting diet lowers risks for major diseases

Scientifically-designed fasting diet lowers risks for major diseases

What if you could lose weight and reduce your risk of life-threatening disease without any changes in what you eat—other than a five-day special diet once every few months? That’s what happened …

Megan McCain (Photo by Will Taylor); featured image for Megan McCain receives American Heart Association Faculty Award

Megan McCain receives American Heart Association Faculty Award

Megan McCain has received a 2016 Scientist Development Grant from the American Heart Association. The three-year, $231,000 grant supports highly promising early career scientists in cardiovascular and stroke research. McCain—Gabilan Assistant Professor …

Francesca Mariani (Photo by Chris Shinn); featured image for What I’m reading: Top pick from stem cell faculty member Francesca Mariani

What I’m reading: Top pick from stem cell faculty member Francesca Mariani

In a recent study in the journal Cell, Kyle Loh and colleagues in Irving Weissman’s group established a rapid protocol for converting human pluripotent stem cells into mesoderm—the progenitors for heart, skeleton, …

Motor neurons derived from an ALS patient (Image courtesy of the Ichida Lab); featured image for USC announces winners of the Audrey E. Streedain Regenerative Medicine Initiative Awards

USC announces winners of the Audrey E. Streedain Regenerative Medicine Initiative Awards

Two collaborative teams within USC Stem Cell are developing new approaches that could eventually help patients with heart disease, frontotemporal dementia and amyotrophic lateral sclerosis (ALS). The teams are the winners of …

The gene Prkci promotes the generation of differentiated cells (red). However if Prkci activity is reduced or absent, neural stem cells (green) are promoted. (Image by In Kyoung Mah); featured image for A Prkci gene keeps stem cells in check

A Prkci gene keeps stem cells in check

When it comes to stem cells, too much of a good thing isn’t wonderful: producing too many new stem cells may lead to cancer; producing too few inhibits the repair and maintenance …

Coronary vasculature in zebrafish (Image courtesy of Children's Hospital Los Angeles)

Tiny heart, big promise

The heart has its own dedicated blood supply, with coronary arteries that supply oxygen-rich blood to the heart and cardiac veins that remove deoxygenated blood. This system of vessels nourishes the heart, …

Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC (Photo by Chris Shinn); featured image for Take a tour of USC’s stem cell research center

Take a tour of USC’s stem cell research center

Video by Alric Devotta Director Andy McMahon leads a tour of the Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC.