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Research
Department Faculty

  • Andrew P. McMahon
    W.M. Keck Provost and University Professor of Stem Cell Biology and Regenerative Medicine, and Biological Sciences; Chair, Stem Cell Biology and Regenerative Medicine; Director, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC
    Dr. McMahon’s laboratory explores the mechanisms that maintain stem/progenitor cells and regulate their differentiation to mature cell types of different organ systems, particularly the kidney. By combining genetic and genomic approaches with high resolution imaging, his group is aiming to obtain a deeper understanding of stem cell biology and to develop novel therapeutic strategies for regenerative medicine.
  • Mohamed Abou-el-Enein
    Associate Professor, Medicine (Oncology), Pediatrics, Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of USC; Executive Director, USC/CHLA Cell Therapy Program; Member, USC Norris Comprehensive Cancer Center
  • Albert Almada
    Assistant Professor, Orthopaedic Surgery, Stem Cell Biology and Regenerative Medicine
    Dr. Almada’s laboratory is investigating one of the greatest mysteries in regenerative biology: how stem cells rebuild functional tissues and organs after traumatic injury. His multidisciplinary team models this biological phenomenon in skeletal muscle, where they discover new pro-regenerative molecules and evaluate their therapeutic potential.
  • Oliver Bell
    Assistant Professor, Biochemistry and Molecular Medicine, Stem Cell Biology and Regenerative Medicine
    Dr. Bell's lab aims to illuminate the epigenetic mechanisms that establish and maintain stable gene expression states. Ultimately, we aim to unravel the crosstalk between epigenetic regulation and cell plasticity.
  • Michael Bonaguidi
    Assistant Professor, Stem Cell Biology and Regenerative Medicine, Gerontology, Biomedical Engineering
    Dr. Bonaguidi and his team investigate brain development, adaptation and aging through the lens of individual neural stem cells. His laboratory takes an integrative approach to establishing fundamental principles of tissue plasticity with the purpose of identifying and overcoming the limits of endogenous brain repair.
  • Paula Cannon
    Distinguished Professor, Molecular Microbiology and Immunology, Pediatrics, Biochemistry and Molecular Biology, Stem Cell Biology and Regenerative Medicine
    Dr. Cannon’s research is focused on viruses, stem cells and gene therapy. The viruses that her laboratory studies are HIV-1 and several biodefense related viruses, such as Ebola and Junin, that cause severe viral hemorrhagic fevers.
  • Yang Chai
    University Professor and George and MaryLou Boone Chair in Craniofacial Molecular Biology; University Professor, Stem Cell Biology and Regenerative Medicine; Director, Center for Craniofacial Molecular Biology; Associate Dean of Research, Ostrow School of Dentistry of USC
    Dr. Chai’s laboratory is interested in early craniofacial development and malformations, including the molecular regulation of cranial neural crest cells. His laboratory has developed genetically engineered mouse models, and has made important discoveries about the mesenchymal stem cell (MSC) niche in the craniofacial region and about utilizing MSCs with 3D printed scaffolds for tissue regeneration.
  • Gage Crump
    Professor, Stem Cell Biology and Regenerative Medicine
    Dr. Crump uses zebrafish to understand how the cartilages and bones of our faces are patterned during development. His lab is discovering the local tissue-tissue interactions that control skeletal differentiation and morphogenesis in vivo, and also exploring novel ways of regenerating bone in adults.
  • Denis Evseenko
    J. Harold and Edna LaBriola Chair in Genetic Orthopedic Research; Associate Professor, Orthopaedic Surgery, Stem Cell Biology and Regenerative Medicine
    The Evseenko Lab research program is designed to form a bridge between basic studies of early embryogenesis, stem cell biology, and the clinically relevant application of stem cell and small molecule-based therapies for degenerative joint disease known as osteoarthritis as well as chronic inflammatory autoimmune diseases of the joint such as rheumatoid arthritis.
  • Scott E. Fraser
    Provost Professor, Biological Sciences and Biomedical Engineering, Stem Cell Biology and Regenerative Medicine; Director, Science Initiatives
    Dr. Fraser has a long-standing interest in the imaging and molecular analysis of intact biological systems, and has been developing new technologies for novel assays. His current research centers on the high-content imaging of embryonic zebrafish and analysis of craniofacial development in avians and mice.
  • Senta Georgia
    Assistant Professor, Endocrinology and Metabolism, Children’s Hospital Los Angeles; Pediatrics, Stem Cell Biology and Regenerative Medicine, USC
    Dr. Georgia’s research involves the regeneration of insulin-producing, pancreatic beta cells as a potential therapeutic for patients with type 1 diabetes. Some of her recent work describes how an enzyme DNMT1 is critical to stem cells differentiating into pancreatic beta cells.
  • Justin Ichida
    John Douglas French Alzheimer’s Foundation Associate Professor of Stem Cell Biology and Regenerative Medicine; New York Stem Cell Foundation-Robertson Investigator
    Dr. Ichida’s research focuses on how genetic and environmental factors contribute to human neurodegenerative disease. His laboratory uses cellular reprogramming and stem cell technology to build patient-specific in vitro models of neurodegenerative disease, enabling the screening of drug-like compounds in search of potential therapeutics.
  • Unmesh Jadhav
    Assistant Professor, Stem Cell Biology and Regenerative Medicine
    Dr. Jadhav's laboratory explores epigenetic control mechanisms regulating cell plasticity in the intestine.
  • Zhongwei Li
    Assistant Professor, Medicine, Stem Cell Biology and Regenerative Medicine
    Dr. Li and his team aim to bridge basic studies of kidney organogenesis and translational applications of stem/progenitor cell-based kidney regeneration and disease modeling, with the long-term goal of rebuilding the kidney. They achieve this by combining state-of-the-art stem cell technologies and engineering methodologies.
  • Nils Lindström
    Assistant Professor, Stem Cell Biology and Regenerative Medicine
    Dr. Lindstrom's lab studies the molecular mechanisms that control how progenitors that exist during development differentiate into the broad range of cell types that underpin adult organ function. The lab integrates single-cell omic approaches with new microscopy and computational tools to understand how genetic changes cause abnormal differentiation in the kidney and model these genetic changes in the renal stem-cell derived organoid with the aim of identifying new treatments for kidney disease.
  • Thomas Lozito
    Assistant Professor, Orthopaedic Surgery, Stem Cell Biology and Regenerative Medicine
    Dr. Lozito's research compares skeletal regeneration in lizards and salamanders. The ultimate goal is to apply this knowledge to improve regeneration in humans.
  • Rong Lu
    Associate Professor, Stem Cell Biology and Regenerative Medicine, Biomedical Engineering, Medicine, Gerontology; Leukemia & Lymphoma Society Scholar
    Dr. Lu studies stem cell coordination, regulation and malfunction from a single cell perspective, using mouse hematopoietic stem cells as a model system. Research in her laboratory is focused on understanding the differences between individual stem cells and how they are coordinated in sustaining the common blood supply.
  • Francesca Mariani
    Associate Professor, Stem Cell Biology and Regenerative Medicine, Integrative Anatomical Sciences
    Dr. Mariani’s laboratory studies the development and repair of the mammalian skeleton, with an emphasis on the ribs and handplate. They use standard and conditional knock-out techniques in mouse models and mouse embryonic stem (ES) cells.
  • Rob Maxson
    Emeritus Professor, Biochemistry and Molecular Medicine, Stem Cell Biology and Regenerative Medicine
    The overall interest of Dr. Maxson's laboratory is the molecular genetic basis of embryonic pattern formation. They focus on processes that regulate the development of the calvaria, the flat bones that compose the top of the skull.
  • Megan McCain
    Associate Professor and Chonette Early Career Chair, Biomedical Engineering, Stem Cell Biology and Regenerative Medicine
    Dr. McCain’s group leverages techniques in tissue engineering to understand mechanisms of development and disease on the cell and tissue level. They develop and utilize tools that can probe structure-function relationships in engineered cells and tissues across multiple spatial and temporal scales.
  • Leonardo Morsut
    Assistant Professor, Stem Cell Biology and Regenerative Medicine, Biomedical Engineering
    Dr. Morsut is developing synthetic biology approaches for mammalian multicellular systems. His laboratory is engineering synthetic cell-cell communication pathways to advance tissue engineering applications as well as the fundamental understanding of multicellular dynamics.
  • Giorgia Quadrato
    Assistant Professor, Stem Cell Biology and Regenerative Medicine
    Dr. Quadrato's laboratory focuses on understanding the cellular and molecular basis of human brain development and disease. By combining the use of emerging models of the human brain with single cell omics approaches, the laboratory is aiming to identify cell type specific disease mechanisms, and above all, new treatments for human neurodevelopmental disorders.
  • Neil Segil
    Professor, Department of Stem Cell Biology and Regenerative Medicine, USC Tina and Rick Caruso Department of Otolaryngology – Head and Neck Surgery
    Hearing loss and balance disorders affect more than half of adults in the US by retirement age, and loss of sensory hair cells in the inner ear is the major contributor. The long-term goal of Dr. Segil’s laboratory is the regeneration of these sensory hair cells of the inner ear.
  • Qi-Long Ying
    Professor, Stem Cell Biology and Regenerative Medicine, Integrative Anatomical Sciences
    Dr. Ying’s research focuses on understanding how embryonic stem cells decide whether to self-renew or to differentiate.
  • Min Yu
    Associate Professor, Stem Cell Biology and Regenerative Medicine
    Dr. Yu researches the mechanism of cancer metastasis, the major cause of cancer-related death. Her laboratory is gaining a better understanding of the cancer stem cell properties in circulating tumor cells (CTCs) and obtaining novel insights on how to target these rare populations.