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California’s stem cell agency hosts public meetings with citizens and patients

By  Kevin McCormack

Posted July 16, 2015
Reading Time 3 minutes

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CIRM President C. Randal Mills (left) (Photo by Gerald Devotta)

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CIRM President Randy Mills addresses citizens and patient advocates at USC (Photo by Cristy Lytal)
CIRM President Randy Mills addresses citizens and patient advocates at USC (Photo by Cristy Lytal)

This summer, leaders from the California Institute for Regenerative Medicine (CIRM) visited Los Angeles, San Diego and San Francisco to consult with citizens and patient advocates in each city. These are the citizens who originally voted to create CIRM to dispense $3 billion to fund stem cell research in California, and the patients and advocates who will benefit when this research leads to new treatments for diseases.

At the meetings, one of which took place at the Eli and Edythe Broad Center for Regenerative Medicine at USC, CIRM President Randy Mills discussed CIRM’s Strategic Plan. He underscored the agency’s mission of accelerating the development of stem cell therapies to patients with unmet medical needs. He described how CIRM is making rapid progress in achieving this mission with 12 projects in clinical trials and close to one billion dollars left in the bank.

Mills also discussed “CIRM 2.0” and the development of a process to fund research that is easier, faster and more responsive to the needs of the scientists and companies developing new therapies.

Some of the patient advocates asked if CIRM ever considered devoting its remaining resources to a few diseases, such as the 10 largest killers of Americans.

Mills responded: “This is not a popularity contest, you can’t judge need by numbers, deciding the worth of something by how many people have it. We are disease agnostic. What we do is find the best science, and fund it.”

In addition to funding the best science, CIRM seeks to attract greater investment from big pharmaceutical companies and venture capitalists with the goal of moving the most promising projects through clinical trials and into patients. The agency is also focused on getting the Food and Drug Administration (FDA) to approve therapies for clinical trials.

Many patient advocates expressed frustration at the FDA’s slow pace.

Mills said that the FDA is caught between a rock and a hard place — criticized if it approves too slowly and chastised if it approves too quickly, green lighting a therapy that later proves to have problems. But he agreed that changes are needed: “The regulatory framework works well for things like drugs and small molecules that can be taken in pills, but it doesn’t work well for cellular therapies like stem cells. It needs to do better at that.”

One advocate suggested a boot camp for researchers, drilling them in the skills they’ll need to get FDA approval. Others suggested applying political pressure from patient advocacy groups to push for change.

As always, there are no easy answers, but the meetings certainly raised many great questions.

As Chris Stiehl, a patient advocate for type 1 diabetes, said in San Diego: “Let the patient be in the room, let them be part of the conversation about these therapies. They are the ones in need, so let them help make decisions about them right from the start, not at the end.”

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