Overview

USC Stem Cell scientists are advancing our understanding of how the body develops, maintains and repairs the kidney and urinary system. They are also developing new regenerative treatments for the millions of patients with kidney injury and disease, bladder injury and disease, and urinary incontinence.

Statistics

  • One in 10 adults in the U.S.—more than 20 million people—are suffering from some degree of chronic kidney disease. Common causes include diabetes and high blood pressure.
  • 13 million people in the U.S. experience urinary incontinence, frequently as a result of childbirth.

Researchers

Kidney and Urinary System News

A circular field of cells shows a gradient of patterns, with green spots decreasing in size as cell density increases.

By exerting “crowd control” over mouse cells, scientists make progress towards engineering tissues

Genes aren’t the sole driver instructing cells to build multicellular structures, tissues, and organs. In a new paper published in Nature Communications, USC Stem Cell scientist Leonardo Morsut and Caltech computational biologist …

Wnt happens in kidney development?

A pair of USC Stem Cell mouse studies detail how progenitor cells self-renew, differentiate, and aggregate into early kidney structures, offering insights for the creation of stem cell-based artificial kidneys. A group …

Following an acute kidney injury, damaged cells interact within disease-promoting microenvironments, a process linked to a progression to chronic kidney disease. (Image by Michal Polonsky/Caltech)

New study shows cells get involved in unhealthy relationships after acute kidney injury (AKI) in mice

Using cutting-edge technology, researchers at USC and Caltech develop a comprehensive map of cellular, molecular, and structural changes following AKI, revealing cellular interactions that may lead to chronic kidney disease. A study …

All Kidney and Urinary System News

Kidney and Urinary System Videos

Dr. Nils Lindström's lab studies the molecular mechanisms that control how progenitors that exist during development differentiate into the broad range of cell types that underpin adult organ function. The lab integrates single-cell omic approaches with new microscopy and computational tools to understand how genetic changes cause abnormal differentiation in the kidney and model these genetic changes in the renal stem-cell derived organoid with the aim of identifying new treatments for kidney disease.
All Kidney and Urinary System Videos