Dr. McMahon’s laboratory explores the mechanisms that maintain stem/progenitor cells and regulate their differentiation to mature cell types of different organ systems, particularly the kidney. By combining genetic and genomic approaches with high resolution imaging, his group is aiming to obtain a deeper understanding of stem cell biology and to develop novel therapeutic strategies for regenerative medicine.

Stories

From left, Broad Clinical Research Fellows Wan Jiao, Roshan Rajani and Anthony Squillaro (Photos courtesy of Wan Jiao, Cristy Lytal and Anthony Squillaro); featured image for Broad Clinical Research Fellows strive to regenerate lymph nodes, liver and kidney

Broad Clinical Research Fellows strive to regenerate lymph nodes, liver and kidney

The lymph nodes, liver and kidney are not passive filters for toxins, but complex organ systems that perform an astonishing array of critical functions. To help patients who have suffered damage to …

Andy McMahon (right), director of USC's stem cell research center, highlights the importance of a biotechnology park. (Photo by Steve Cohn)

East LA biotech park could create “explosion of employment”

The competition for biotech investment is escalating, and USC President C. L. Max Nikias wants to make sure Los Angeles emerges a winner. “Los Angeles finds itself falling behind in the race …

Clockwise from top left: Andy McMahon, Rohit Varma, Jonathan Samet and Donna Spruijt-Metz (Photos courtesy of USC); featured image for NIH funding helps Americans live longer and healthier

NIH funding helps Americans live longer and healthier

The nation’s medical research agency, the National Institutes of Health, funds research to help Americans live longer and healthier. Some 148 Nobel Prize winners have received support from the NIH, demonstrating how …

Kidney organoid (Image by Tracy Tran/McMcMahon Lab); featured image for USC’s stem cell scientists secure the dollars to fight disease

USC’s stem cell scientists secure the dollars to fight disease

The price of progress is not only the energy and talent of stem cell scientists, but also the research dollars that support their discoveries. In recent months, faculty members have secured numerous …

Barbara Kolo and Andy McMahon (Photo by Richard Carrasco); featured image for Artist plus researcher equals infinite inspiration at the Keck School of Medicine of USC

Artist plus researcher equals infinite inspiration at the Keck School of Medicine of USC

What happens when you pair 14 artists with 14 USC biomedical researchers? The answer is currently on display at the Hoyt Gallery on the Health Sciences Campus of the Keck School of …

From left, ChangHui Pak, Mayssa H. Mokalled, Naomi Habib, Frank Soldner and Alex J. Hughes (Photo by Cristy Lytal); featured image for Next-generation stem cell scientists evidence strong nerves at USC mini-symposium

Next-generation stem cell scientists evidence strong nerves at USC mini-symposium

Five next-generation scientists got everyone’s neurons firing at the Junior Faculty Candidate Mini-symposium, hosted by USC’s Department of Stem Cell Biology and Regenerative Medicine on March 7.

From left, Andy McMahon and Ken Hallows (Photos by Phil Channing and courtesy of Ken Hallows); featured image for World Kidney Day: USC’s Andy McMahon and Ken Hallows discuss kidney health and research

World Kidney Day: USC’s Andy McMahon and Ken Hallows discuss kidney health and research

One in 10 people is affected by chronic kidney disease worldwide. On March 9, 2017, World Kidney Day shines a spotlight on the importance of kidneys and ways to reduce the impact …

From left: USC relay runners Valeria Mancino, Nils Lindstrom, Qing Liu, Jill McMahon, Kenneth Hallows, Andy McMahon, Daniel Rivera, Nuria Pastor-Soler, Veronica Haro-Acosta and Tracy Tran (Photo by Cristy Lytal); featured image for Support the UKRO Los Angeles Marathon Charity Relay Team

Support the UKRO Los Angeles Marathon Charity Relay Team

One out of every two adults will develop chronic kidney disease during their lifetimes. To help these patients, USC scientists and clinicians are putting their feet to the task as part of …

The Stem Cell Day of Discovery event held at the USC Health Sciences Campus in Los Angeles, CA. February 4th, 2017. The event encourages students to learn more about STEM opportunities, including stem cell study and biotech, and helps demystify the fields and encourage student engagement. Photo by David Sprague; featured image for Five-hundred middle and high school students realized their “pluripotential” at the USC Stem Cell Day of Discovery

Five-hundred middle and high school students realized their “pluripotential” at the USC Stem Cell Day of Discovery

You can be anything you want—just like a stem cell. This was a key lesson for the 500 middle and high school students who attended the USC Stem Cell Day of Discovery …

Eli and Edythe Broad (Photo by Ben Gibbs); featured image for The Broad Foundation gives a tenth birthday gift to the USC, UCLA and UCSF stem cell centers

The Broad Foundation gives a tenth birthday gift to the USC, UCLA and UCSF stem cell centers

Last Friday, scientists from USC, UCLA and UCSF gathered at a symposium to celebrate the tenth anniversary of their three stem cell research centers, established with support from Eli and Edythe Broad …

Denis Evseenko (Photo by Cristy Lytal); featured image for Denis Evseenko receives $2.5 million from California Institute for Regenerative Medicine for osteoarthritis research

Denis Evseenko receives $2.5 million from California Institute for Regenerative Medicine for osteoarthritis research

The Keck School of Medicine of the University of Southern California (USC) is one of four institutions to receive a multi-million dollar grant from the California Institute for Regenerative Medicine (CIRM) for …

Amgen's Bill Richards recently visited USC to provide an introduction to the company. (Photo by Cristy Lytal)

USC and Amgen launch the dialogues that drive discovery

Without collaboration between universities and pharmaceutical companies, scientists might never have developed essential medicines ranging from the antibiotic streptomycin in the 1950s to HIV medications in the 1990s. In recognition of the …

From left, Andy McMahon and Gage Crump (Photos by Phil Channing and the Crump Lab); featured image for What I’m reading: Top picks from stem cell faculty members Andy McMahon and Gage Crump

What I’m reading: Top picks from stem cell faculty members Andy McMahon and Gage Crump

Andy McMahon: Leigh Turner and Paul Knoepfler present a disturbing report in Cell Stem Cell on the growth of businesses marketing stem cell interventions in the US. Los Angeles is one “stem …

Lindsey Barske (Photo by Cristy Lytal); featured image for USC Stem Cell scientist Lindsey Barske wins NIH Pathway to Independence Award

USC Stem Cell scientist Lindsey Barske wins NIH Pathway to Independence Award

Years ago, Lindsey Barske pulled on a pair of tall rubber boots and began a journey that led from her college research experience on the muddy Alaskan tundra to her current postdoctoral …

From left, philanthropists Kin-Chung and Amy Choi with Andy McMahon, chair of the executive committee of USC Stem Cell (Photo by Steve Cohn); featured image for Los Angeles wins bid to host international stem cell conference

Los Angeles wins bid to host international stem cell conference

In recognition of its growing stature as an incubator for the biosciences, Los Angeles will be the host city for the 2019 International Society for Stem Cell Research (ISSCR) Conference. With the …

From left, philanthropists Kin-Chung and Amy Choi with Andy McMahon, director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC (Photo by Steve Cohn); featured image for The Choi Family’s gift inspires USC Stem Cell scientists to “Return to the Beginning”

The Choi Family’s gift inspires USC Stem Cell scientists to “Return to the Beginning”

Twenty-five years ago, philanthropists Kin-Chung and Amy Choi marked the occasion of their 25th wedding anniversary by purchasing the sculpture “Return to the Beginning,” by renowned Taiwanese artist Yuyu Yang. Now in …

Ophir Klein, professor at the University of California, San Francisco, delivered the keynote address. (Photo by Cristy Lytal); featured image for Next generation of stem cell scientists detail their research from head to toe

Next generation of stem cell scientists detail their research from head to toe

The Stem Cell and Developmental Biology Retreat was a total body experience — covering organ systems ranging from the brain to the skeleton, from the kidney to the heart. Held on May …

New ways to regenerate bone emerge from the adult zebrafish face. (Image by Sandeep Paul and Seth Ruffins); featured image for USC Stem Cell researchers use zebrafish to understand the role of cartilage in bone repair

USC Stem Cell researchers use zebrafish to understand the role of cartilage in bone repair

Scientists have long believed that the processes required for embryonic development are recapitulated during the regeneration of damaged body parts, such as fractured bones. In a new study published in Development, USC …

Justin Ichida (Photo by Cristy Lytal); featured image for USC Stem Cell scientist Justin Ichida named New York Stem Cell Foundation – Robertson Investigator

USC Stem Cell scientist Justin Ichida named New York Stem Cell Foundation – Robertson Investigator

Some people see an award as remuneration for work well done. Upon being named a New York Stem Cell Foundation – Robertson Investigator, ALS researcher Justin Ichida sees his award as motivation …

Rendition of developing vertebrate bones. In their study, Hojo and colleagues address the transcriptional action and evolution of Sp7/Osx, a key determinant of vertebrate-restricted bone forming osteoblasts. (Painting by Kristen Chen; courtesy of Developmental Cell 2016); featured image for USC Stem Cell study illuminates bone formation and vertebrate evolution

USC Stem Cell study illuminates bone formation and vertebrate evolution

With the emergence of bone, the diversity of life expanded to encompass the bone-forming vertebrates, a group of species ranging from the tiny frog Paedophryne amauensis to the mighty blue whale. Bone …