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After surgical rib resection (top), a cartilage and bone bridge form (second from top) and then resolve (third from top) and remodel to regenerate the missing tissue in the gap (bottom). Blue shows cartilage matrix; red shows mineralized matrix. (Images by Stephanie Kuwahara and Max Serowoky/ Mariani Lab)

For large bone injuries, it’s Sonic hedgehog to the rescue

A USC Stem Cell study in NPJ Regenerative Medicine presents intriguing evidence that large bone injuries might trigger a repair strategy in adults that recapitulates elements of skeletal formation in utero. Key …

Osteoblasts

Broad Clinical Fellows take a stem cell-based approach to liver disease and bone loss

This year’s Broad Clinical Research Fellows are developing stem cell-based approaches for patients of all ages—from two-week-old infants with liver disease, to senior citizens with bone loss following joint replacement surgeries. Since …

Frank Petrigliano, MD, and Denis Evseenko, MD, PhD, have been collaborating on medical innovations to help heal and even regenerate damaged joints. (Photo/Ricardo Carrasco III)

Sports medicine innovations are helping weekend warriors stay in the game

Call them recreational athletes. Couch-to-5K joggers. Weekend warriors. Whichever name you use, they’re the ones who wait all week to hit the soccer field, basketball court or running trail on Saturday morning. They’re …

Frank Petrigliano

Frank Petrigliano named chief of USC Epstein Family Center for Sports Medicine

The USC Epstein Family Center for Sports Medicine at Keck Medicine of USC, which specializes in treating sports-related and recreational injuries affecting the shoulder, knee, hip and elbow, recently announced the appointment …

USC researchers converge at the Interdisciplinary Stem Cell Symposium

“The field of stem cell biology is one of our great convergence opportunities,” said USC Provost Michael Quick, addressing an audience of biologists, chemists, physicists, engineers, clinicians and many others. This diverse …

Epstein family gift enhances sports medicine research and care at USC

Researchers and clinicians at the Keck School of Medicine of USC’s Department of Orthopaedic Surgery will advance their pioneering work on treatments and techniques to prevent and heal sports-related injuries thanks to a new …

Growing hope: New organs? Not yet, but stem cell research is getting closer

If you lose a limb, it’s lost for life. If you damage a kidney, you won’t grow a new one. And if you have a heart attack, the scars are there to …

Broad Clinical Research Fellows use stem cells to build bone and combat cancer

This year’s Broad Clinical Research Fellows will apply stem cell-based approaches to two prevalent problems: non-healing bone injuries, which affect 5 million Americans each year; and neuroblastoma, which is the most common …

Jay R. Lieberman receives $2.2 million NIH grant to fund research on healing difficult bone injuries

Jay R. Lieberman, chair and professor of orthopedic surgery at the Keck School of Medicine of the University of Southern California has received a five-year, $2.2 million grant from the National Institutes …

Bone defects inspire perfect union between surgeon-scientist and stem cell researchers at USC

As chair of the Department of Orthopaedic Surgery at the Keck School of Medicine of USC, Jay R. Lieberman regularly sees patients with bone defects too severe to heal. This unmet clinical …

Denis Evseenko receives $2.5 million from California Institute for Regenerative Medicine (CIRM) for osteoarthritis research

The Keck School of Medicine of the University of Southern California (USC) is one of four institutions to receive a multi-million dollar grant from the California Institute for Regenerative Medicine (CIRM) for …

USC Stem Cell names second cohort of Broad Clinical Research Fellows

The second cohort of Broad Clinical Research Fellows is making strides towards finding stem cell-based therapies for lymphedema in cancer patients, large bone fractures and short bowel syndrome.

Lieberman takes office as 25th president of national association

Jay R. Lieberman, a principal investigator with USC Stem Cell, is the new president of the American Association of Hip and Knee Surgeons (AAHKS). He is professor and chair of the Department …

A Retreat from everything but stem cells

It wasn’t the pristine 27-hole course that drew more than 120 stem cell researchers from USC and beyond to the Desert Princess Golf Resort near Palm Springs. It was the sixth annual …

USC announces winners of first Regenerative Medicine Initiative awards

Three newly assembled disease teams within USC Stem Cell will take the early steps this year that might lead to future stem-cell based therapies for certain forms of deafness, bone defects and …