Dr. Gnedeva’s laboratory interrogates how molecular signaling and tissue mechanics control embryonic sensory organ growth and how the developmental programs of self-renewal and differentiation can be re-initiated in the mammalian inner ear after damage. Although the focus is on hearing and balance restoration, the lab has broader interest in the common mechanisms that suppress regeneration in specialized sensory tissues.


Rows of sensory hearing cells (green) next to supporting cells (red) in the inner ear of a mouse (Image by John Duc Nguyen and Juan Llamas/Segil Lab)

USC Stem Cell mouse studies tune into hearing regeneration

A deafened adult cannot recover the ability to hear, because the sensory hearing cells of the inner ear don’t regenerate after damage. In two new studies, partially funded by the National Institutes …

Ksenia Gnedeva, PhD