Each year, approximately 100,000 patients in the U.S. are in need of a kidney transplant, yet only about 20,000 donor organs are available. To help close this gap, a team of scientists led by Zhongwei Li is working to build a synthetic kidney grown from human stem cells. These stem cells will follow early developmental processes similar to normal embryonic kidney development, and then complete their maturation inside of the recipient’s own body.

USC Stem Cell scientists are advancing our understanding of how the body develops, maintains and repairs the kidney and urinary system. They are also developing new regenerative treatments for patients with kidney injury and disease, bladder disorders, and urinary incontinence.

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Illustrations by Doug Chayka

Cell by cell: Rebuilding the body

USC researchers are revolutionizing how we treat disease by harnessing stem cells as “living medicine.” Anyone who’s healed from a cut or a scrape has witnessed the incredible regenerative power of stem …

Laura Perin in the lab (image courtesy of CHLA)

Fasting-mimicking diet restores kidney function in study

Diet intervention revives kidney function in preclinical animal models and in patients with chronic kidney disease. In patients with chronic kidney disease, the loss of podocytes—part of the kidney’s glomerular filtration barrier—causes …

Wnt happens in kidney development?

A pair of USC Stem Cell mouse studies detail how progenitor cells self-renew, differentiate, and aggregate into early kidney structures, offering insights for the creation of stem cell-based artificial kidneys. A group …

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Dr. Nils Lindström's lab studies the molecular mechanisms that control how progenitors that exist during development differentiate into the broad range of cell types that underpin adult organ function. The lab integrates single-cell omic approaches with new microscopy and computational tools to understand how genetic changes cause abnormal differentiation in the kidney and model these genetic changes in the renal stem-cell derived organoid with the aim of identifying new treatments for kidney disease.
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