With funding from the California Institute for Regenerative Medicine (CIRM) and Sangamo Biosciences, City of Hope conducted a clinical trial for patients with HIV/AIDS based on discoveries made by USC researcher Paula Cannon. She pioneered a technique for genetically engineering a patient’s own immune cells to resist HIV infection. Globally, 36.7 million people are living with HIV, and 1.8 million of these are children. An estimated 35 million people have died from HIV-related causes so far.

Scientists at USC Stem Cell are also using gene editing technology to study and develop treatments for diseases ranging from diabetes to cancer.

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USC team develops a powerful new analytical tool to advance CAR T cell therapy research

The comprehensive analytical platform uses laser technology to analyze CAR T cells and has already revealed ways to optimize their manufacturing, including how to identify when CAR T cells are likely to …

USC biomedical engineers have harnessed focused ultrasound to improve CRISPR, a revolutionary tool that enables the DNA in living organisms to be modified. (Image byWang Lab and Pepper Workshop)

New CRISPR toolkit to allow remote-controlled genome editing

USC Viterbi biomedical engineers harness focused ultrasound to revolutionize CRISPR’s capabilities to treat countless diseases. Thanks to CRISPR, our medical specialists will soon have unprecedented control over how they treat and prevent …

A circular field of cells shows a gradient of patterns, with green spots decreasing in size as cell density increases.

By exerting “crowd control” over mouse cells, scientists make progress towards engineering tissues

Genes aren’t the sole driver instructing cells to build multicellular structures, tissues, and organs. In a new paper published in Nature Communications, USC Stem Cell scientist Leonardo Morsut and Caltech computational biologist …

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The University of Southern California has designed a unique “incubator” for scientists, engineers and clinicians to collaborate across disciplines and leverage the transformative power of stem cells to develop the future of regenerative medicine. The USC Stem Cell incubator trains the next generation of scientists through a dedicated PhD program and first-of-its-kind master’s degree, and brings together leading researchers from around the world to gain insights into developmental biology and advance new treatments for human disease. Learn more at http://stemcell.keck.usc.edu.
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