With funding from the California Institute for Regenerative Medicine (CIRM) and Sangamo Biosciences, City of Hope conducted a clinical trial for patients with HIV/AIDS based on discoveries made by USC researcher Paula Cannon. She pioneered a technique for genetically engineering a patient’s own immune cells to resist HIV infection. Globally, 36.7 million people are living with HIV, and 1.8 million of these are children. An estimated 35 million people have died from HIV-related causes so far.

Scientists at USC Stem Cell are also using gene editing technology to study and develop treatments for diseases ranging from diabetes to cancer.

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Biomedical engineers at USC Viterbi are using ultrasound to trick tumor cells into effectively painting a target on their own backs, enabling more powerful treatments. Image/ChatGPT.

Tricking tumors into marking themselves for destruction

New research from the USC Viterbi School of Engineering harnesses focused ultrasound to reprogram solid tumors, making them more effective targets for immune cells. USC biomedical engineers have found a way to …

Genetically engineered chimeric antigen receptor immune cell (image courtesy of iStock)

Next-generation CAR T cells could expand solid cancer treatment options

Using cell cultures and animal models, researchers from the USC Norris Comprehensive Cancer Center at Keck School of Medicine of USC showed that innovative ways to further engineer CAR T cells can …

Embryonic stem cells from a Barred Plymouth Rock chicken (Image by Xi Chen/Ying Lab/USC Stem Cell)

USC Stem Cell-led study generates authentic embryonic stem cells from birds

Scientists discover that egg yolk is a key to establishing authentic embryonic stem cells from chickens and seven other avian species, as reported in Nature Biotechnology. Egg whites may be perfect for …

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The University of Southern California has designed a unique “incubator” for scientists, engineers and clinicians to collaborate across disciplines and leverage the transformative power of stem cells to develop the future of regenerative medicine. The USC Stem Cell incubator trains the next generation of scientists through a dedicated PhD program and first-of-its-kind master’s degree, and brings together leading researchers from around the world to gain insights into developmental biology and advance new treatments for human disease. Learn more at http://stemcell.keck.usc.edu.
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