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Leonardo Morsut

USC Stem Cell scientist Leonardo Morsut awarded $2.5 million NIH grant to explore “synthetic” embryonic development

Whether in an earthworm or a human being, developmental processes are driven by complex networks of genetically-encoded signals that enable cells to take cues from each other and their environment. To begin unraveling this complexity, USC Stem Cell scientist Leonardo Morsut is designing artificial genetic programs to perturb natural signaling networks and study how this …

In the cGMP facility space before construction. From left: Mohamed Abou-el-Enein; Tom Buchanan; Alan S. Wayne; Caryn Lerman; and Nikos Carli. (Photo/Sergio Bianco)

CHLA, Keck School, Keck Medicine and USC Norris partner on cell therapy program as construction on new facility begins

The essence of translational medicine is taking an idea from the drawing board and “translating” it into a real-world treatment that helps patients. The winding road of that process takes plenty of time, money and expertise, so it makes sense to place it all under one roof. USC and Children’s Hospital Los Angeles (CHLA) are …

Xi Chen

For USC scientist Xi Chen, a chicken is more than just an egg’s way of making another egg

USC postdoctoral researcher Xi Chen knows that you have to break a few eggs in order to grow chicken stem cells. His work on maintaining embryonic stem cells (ESC) from chicken eggs provides insight into stem cell pluripotency and evolutionary developmental biology. “The choice of beginning with fertilized chicken eggs was critical to the success …

Osteoblasts

Broad Clinical Fellows take a stem cell-based approach to liver disease and bone loss

This year’s Broad Clinical Research Fellows are developing stem cell-based approaches for patients of all ages—from two-week-old infants with liver disease, to senior citizens with bone loss following joint replacement surgeries. Since 2015, the Broad Clinical Research Fellowships have enabled physician-scientists at USC, UCLA and the University of California, San Francisco, to engage in one …

Rekha Prakash

USC alumna Rekha Prakash brings biotech background to Roosevelt High School

As a LAUSD biotechnology instructor at Roosevelt High School, Rekha Prakash works two short miles from USC’s Health Sciences Campus, where she earned her master of science degree in stem cell biology and regenerative medicine in 2015. “I teach biomedical sciences,” she said. “It’s not a regular biology class. This is totally career technical education. …

Senta in the lab

Can COVID-19 cause diabetes?

Can the novel coronavirus—SARS-CoV-2—cause diabetes? No one knows, but Senta Georgia, PhD, is trying to find out. Dr. Georgia, an investigator in The Saban Research Institute of Children’s Hospital Los Angeles, recently received a $100,000 peer-reviewed grant from the American Diabetes Association to examine the impact of SARS-CoV-2 on pancreatic beta cells (cells in the …

Happy 10th Anniversary, BCC!

Happy 10th anniversary to USC’s stem cell research center

On October 29, 2010, we opened the doors of the Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC. Today, on the 10th anniversary of the building’s grand opening, we reflect on a decade of progress in a celebratory video, featuring messages from everyone from USC President Carol Folt …

Tracy Grikscheit

USC pediatric surgeon aims to heal infants using stem cells

Tracy Grikscheit helps babies with digestive disorders. Stem cells could help her develop life-changing treatments. It’s an instinct many surgeons have: Whatever you have to remove, replace it with something better. Something that helps. Tracy Grikscheit hopes to get there one day with the tiny patients she serves. Grikscheit is a principal investigator at USC …

D. Brent Polk

Treatment for Inflammatory bowel disease doesn’t always work; new study uncovers why

Inflammatory bowel disease (IBD) affects more than 70,000 children in the United States and the prevalence is rising. In fact, 25% of the 3.1 million individuals with IBD present before 21 years of age. There is no cure for IBD, and treatment often includes medication to block a molecule that causes inflammation in the intestines …

Fraser by Noe Montes

USC biological imaging innovator elected to National Academy of Medicine

Scott Fraser, Provost Professor of Biological Sciences, Biomedical Engineering, Physiology and Biophysics, Stem Cell Biology and Regenerative Medicine, Pediatrics, Radiology and Ophthalmology, has been elected to the National Academy of Medicine. Fraser, who holds joint appointments at the USC Dornsife College of Letters, Arts and Sciences and USC Viterbi School of Engineering as well as …

California’s biggest stem cell experiment: The impact of the stem cell ballot proposition at USC

In 2008, USC broke ground on an $80 million building dedicated solely to stem cell research and regenerative medicine. The plans called for a monolithic structure clad in black marble and reflective glass, rising five stories and enclosing nearly 90,000 square feet. When it was completed, the university had a stunning new contemporary research space …

Scott E. Fraser

USC’s Scott E. Fraser elected to National Academy of Medicine

USC biophysicist Scott E. Fraser, PhD, has as been elected to the National Academy of Medicine, the organization announced Monday. He’s among 100 new members of the Academy. “For integrating biophysics, quantitative biology, and molecular imaging to enable unprecedented views of normal function and disease in live organisms, from embryonic development to old age,” the …

Stem cells

USC’s stem cell master’s program awards new scholarships and welcomes its largest incoming class

This fall, USC’s master’s program in Stem Cell Biology and Regenerative Medicine will be providing a remote learning experience for its largest incoming class to date. The incoming class of 46 students is a diverse group: the cohort is 63 percent female, 20 percent international, and includes both a physician and a rabbi. Six of …

diabetes

Treating type 2 diabetes in youth

The occurrence of Type 2 diabetes in youth is increasing, yet the ability to control the disease by regulating blood glucose levels has proven difficult for this age group. A study published in the journal Pediatric Diabetes by investigators at Children’s Hospital Los Angeles found that patients who lost weight in the first year following …

Remote learning

USC Stem Cell’s high school program Zooms ahead

In late February 2020, 10 local high school juniors gathered at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC for the first meeting of a four-month hands-on learning experience, sponsored by the Amgen Foundation. Each of the 10 students had been nominated by a science teacher from an …

fasting and breast cancer

Studies suggest a fasting diet could boost breast cancer therapy

A USC-led team of scientists has found that a fasting-mimicking diet combined with hormone therapy has the potential to help treat breast cancer, according to newly published animal studies and small clinical trials in humans. In studies on mice and in two small breast cancer clinical trials, researchers at USC and the IFOM Cancer Institute …

ombuds

What is the USC Ombuds?

Stress levels are running high with a pandemic, global recession, and social injustice threatening livelihoods and lives. While the USC Office of the Ombuds can’t resolve the world’s woes, it can serve as a confidential, impartial, informal, and independent problem-solving resource for students, faculty and staff. The University Ombuds—Thomas Kosakowski at the Health Sciences Campus, …

Men are from Mars

New award supports study of why females age differently than males

A new research project led by USC Leonard Davis School of Gerontology Assistant Professor Bérénice Benayoun aims to learn more about why female mammals, including humans, age differently than males. Sex dimorphism – physiological characteristics that differ between the sexes in a species – can have big implications for health and lifespan. Human longevity differs …

Writing

Manuscript writing course for KSOM students and postdocs

Are you a KSOM postdoc or graduate student working on a manuscript? Whether you’re staring at a blank page, or going through the umpteenth round of revisions, this free workshop will get you ready to submit your manuscript to a scientific journal. Offered via Zoom, the 4-week workshop will start on Tuesday, May 26, at …

Hirschsprung’s Disease

Growing nerve cells in the gut

The human body has what is sometimes called a “second brain” in the digestive tract. The enteric nervous system (ENS) performs many vital functions, including coordinating the movement of food to allow the body to absorb nutrients. When babies are born with an incomplete or absent ENS, their prognosis is extremely serious. In a new …

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