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Digestion and Metabolism News
D. Brent Polk (Photo courtesy of Children's Hospital Los Angeles)

D. Brent Polk named AAAS fellow

D. Brent Polk, a member of the USC Stem Cell executive committee and vice dean for clinical affairs at Children’s Hospital Los Angeles (CHLA), is among five USC scientists who have been …

Senta Georgia (Photo by Cristy Lytal); featured image for What I’m Reading: Top pick from stem cell faculty member Senta Georgia

What I’m Reading: Top pick from stem cell faculty member Senta Georgia

Earlier this year, a team at the Karolinska Institute published a paper that profiled gene activity in single cells from human embryos created in the context of in vitro fertilization. Now this …

Qi-Long Ying (Photo by Cristy Lytal); featured image for What I’m Reading: Top pick from stem cell faculty member Qi-Long Ying

What I’m Reading: Top pick from stem cell faculty member Qi-Long Ying

In a recent study published in Cell Stem Cell, Joshua Black and colleagues demonstrated that skin cells are converted into neurons using a powerful tool called CRISPR/Cas9 to concurrently modify and activate …

Wange Lu (Photo by Chris Shinn); featured image for What I’m reading: Top pick from stem cell faculty member Wange Lu

What I’m reading: Top pick from stem cell faculty member Wange Lu

Our genetic material is packed into the nucleus of the cell, but is the packing process random or organized in some way? In a recent study published in Cell Stem Cell, Krijger …

Biodegradable scaffold (left) and human tissue-engineered liver (right) (Photo courtesy of The Saban Research Institute at Children’s Hospital Los Angeles); featured image for Functional human tissue-engineered liver generated from stem and progenitor cells

Functional human tissue-engineered liver generated from stem and progenitor cells

A research team led by investigators at The Saban Research Institute of Children’s Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor cells. Tissue-engineered Liver …

Joseph T. Rodgers (Photo by Cristy Lytal); featured image for What I’m reading: A top pick from stem cell faculty member Joseph T. Rodgers

What I’m reading: A top pick from stem cell faculty member Joseph T. Rodgers

In a recent issue of Science, Jay Shendure, Alexander Schier and colleagues present an extraordinarily powerful new approach to trace the lineage of cells as they divide within an organism.

Senta Georgia (Photo by Cristy Lytal); featured image for What I’m reading: A top pick from stem cell faculty member Senta Georgia

What I’m reading: A top pick from stem cell faculty member Senta Georgia

In the human pancreas, groups of so-called “endocrine cells” secrete the hormones insulin and glucagon, which are critical for regulating blood glucose levels; dysregulation of hormone secretion can lead to diabetes. In …

Senta Georgia (Photo by Cristy Lytal); featured image for USC Stem Cell researcher Senta Georgia wins CIRM Discovery Inception award

USC Stem Cell researcher Senta Georgia wins CIRM Discovery Inception award

Senta Georgia—principal investigator at Children’s Hospital Los Angeles (CHLA), and assistant professor of pediatrics, and stem cell biology and regenerative medicine at USC—has a creative idea for helping children with a genetic …

From left, Andy McMahon and Gage Crump (Photos by Phil Channing and the Crump Lab); featured image for What I’m reading: Top picks from stem cell faculty members Andy McMahon and Gage Crump

What I’m reading: Top picks from stem cell faculty members Andy McMahon and Gage Crump

Andy McMahon: Leigh Turner and Paul Knoepfler present a disturbing report in Cell Stem Cell on the growth of businesses marketing stem cell interventions in the US. Los Angeles is one “stem …

Valter Longo (Photo by John Skalicky); featured image for Fasting-like diet turns the immune system against cancer

Fasting-like diet turns the immune system against cancer

A fasting-like diet with chemotherapy strips away the guard that protects breast cancer and skin cancer cells from the immune system, according to a new USC-led study on mice. The study was …

From left, Broad Clinical Research Fellows Christopher Schlieve, Gene K. Lee and R. Kiran Alluri; featured image for USC Stem Cell names second cohort of Broad Clinical Research Fellows

USC Stem Cell names second cohort of Broad Clinical Research Fellows

The second cohort of Broad Clinical Research Fellows is making strides towards finding stem cell-based therapies for lymphedema in cancer patients, large bone fractures and short bowel syndrome.

Stem cells self-organize to form a hollow ball of cells. (Image by In Kyoung Mah and Francesca Mariani); featured image for A gene called Prkci helps organize organisms and their organs

A gene called Prkci helps organize organisms and their organs

A gene called Prkci can point cells in the right direction, according to a new study in Developmental Biology. In the study, USC Stem Cell researcher In Kyoung Mah from the laboratory …

Valter Longo (Photo by Dietmar Quistorf); featured image for Diet that mimics fasting may also reduce multiple sclerosis symptoms

Diet that mimics fasting may also reduce multiple sclerosis symptoms

Evidence is mounting that a diet mimicking the effects of fasting has health benefits beyond weight loss, with a new USC-led study indicating that it may reduce symptoms of multiple sclerosis. Scientists …

Malcolm Snead (Photo courtesy of the Ostrow School of Dentistry of USC); featured image for Amplifying cell signals for potentially lower cost stem cell interventions

Amplifying cell signals for potentially lower cost stem cell interventions

Editor’s Note: USC Stem Cell principal investigators Malcolm Snead and Yan Zhou were among the authors of “Supramolecular Nanofibers Enhance Growth Factor Signaling by Increasing Lipid Raft Mobility,” published on April 12, …

3-D printed Cas9 enzyme that snips a DNA sequence at a location identified by CRISPR. (Photo courtesy of the NIH 3D Print Exchange, National Institutes of Health); featured image for USC Stem Cell scientists enter the conversation about CRISPR

USC Stem Cell scientists enter the conversation about CRISPR

CRISPR-Cas9 is a gene-editing technique that enables scientists to disable, replace or modify sections of DNA. It allows for unprecedented precision and speed in the field of genome editing. It has been used to …

Tracy C. Grikscheit; featured image for Stem cell researcher Tracy Grikscheit awarded $7.1 million by CIRM

Stem cell researcher Tracy Grikscheit awarded $7.1 million by CIRM

Tracy C. Grikscheit, a principal investigator with USC Stem Cell and The Saban Research Institute of Children’s Hospital Los Angeles, has received a $7.1 million grant from the California Institute for Regenerative …

From left, Hsiang-Ying (Sherry) Lee, Sergei Doulatov, Leonardo Morsut, Alexander Pollen and Joan Font-Burgada (Photo by Cristy Lytal); featured image for USC Stem Cell mini-symposium introduces next-generation researchers

USC Stem Cell mini-symposium introduces next-generation researchers

The next generation of scientists is turning to stem cells to advance our understanding of systems ranging from the blood to the brain, from the liver to the lungs. Six of these …

Qi-Long Ying (Photo by Cristy Lytal); featured image for Scientists Qi-Long Ying and Austin Smith win the 2016 McEwen Award for Innovation

Scientists Qi-Long Ying and Austin Smith win the 2016 McEwen Award for Innovation

Video by Henry Liu Researchers Qi-Long Ying from USC and Austin Smith from the University of Cambridge have won the 2016 McEwen Award for Innovation, the highest honor bestowed by the International …

Chemotherapy kills most cancer cells, but cancer stem cell survive and seed a new tumor that resists chemotherapy.; featured image for Scientists root out the “bad seeds” of liver cancer

Scientists root out the “bad seeds” of liver cancer

Researchers have found the “bad seeds” of liver cancer and believe they could one day reprogram them to remain responsive to cancer treatment, according to a new study in the January 12 …

The gene Prkci promotes the generation of differentiated cells (red). However if Prkci activity is reduced or absent, neural stem cells (green) are promoted. (Image by In Kyoung Mah); featured image for A Prkci gene keeps stem cells in check

A Prkci gene keeps stem cells in check

When it comes to stem cells, too much of a good thing isn’t wonderful: producing too many new stem cells may lead to cancer; producing too few inhibits the repair and maintenance …