From professional volleyball to stem cell biology, Leonardo Morsut is at the top of his game
For USC Stem Cell researcher Leonardo Morsut, the word “set” refers to a collection of scientific data. “Set” is also the prelude to spiking a volleyball over the net—something he used to do for a living as a professional athlete in Italy.
Drugs widely used in cancer therapy increase toxicity of chemotherapy in mice
A short-term fast appears to counteract increases in blood sugar caused by common cancer drugs and protect healthy cells in mice from becoming too vulnerable to chemotherapy, according to new research by …
Researcher Jian Xu earns accolades for cell fate studies
Basic science can often be far from basic—especially for Jian Xu, who believes cells are kind of like people. “In simple terms, we look at how cells determine their own fate,” said …
Scientifically-designed fasting diet lowers risks for major diseases
What if you could lose weight and reduce your risk of life-threatening disease without any changes in what you eat—other than a five-day special diet once every few months? That’s what happened …
Beating the spread
Cancer cells are like normal cells, only trickier. They carry genetic mutations that can hoodwink their surroundings to favor their growth. Using biologically inspired in vitro models, Keyue Shen, an assistant professor …
What I’m Reading: Top pick from stem cell faculty member Senta Georgia
Earlier this year, a team at the Karolinska Institute published a paper that profiled gene activity in single cells from human embryos created in the context of in vitro fertilization. Now this …
What I’m Reading: Top pick from stem cell faculty member Qi-Long Ying
In a recent study published in Cell Stem Cell, Joshua Black and colleagues demonstrated that skin cells are converted into neurons using a powerful tool called CRISPR/Cas9 to concurrently modify and activate …
What I’m reading: Top pick from stem cell faculty member Wange Lu
Our genetic material is packed into the nucleus of the cell, but is the packing process random or organized in some way? In a recent study published in Cell Stem Cell, Krijger …
What I’m reading: Top pick from stem cell faculty member Min Yu
In a recent issue of Cell, William Greenleaf, Monte Winslow and colleagues have characterized differences within primary and metastatic tumors in an engineered mouse model of small cell lung cancer (SCLC). Many …
What I’m reading: A top pick from stem cell faculty member Joseph T. Rodgers
In a recent issue of Science, Jay Shendure, Alexander Schier and colleagues present an extraordinarily powerful new approach to trace the lineage of cells as they divide within an organism.
What I’m reading: Top picks from stem cell faculty members Andy McMahon and Gage Crump
Andy McMahon: Leigh Turner and Paul Knoepfler present a disturbing report in Cell Stem Cell on the growth of businesses marketing stem cell interventions in the US. Los Angeles is one “stem …
Fasting-like diet turns the immune system against cancer
A fasting-like diet with chemotherapy strips away the guard that protects breast cancer and skin cancer cells from the immune system, according to a new USC-led study on mice. The study was …
USC Stem Cell researchers receive the inaugural Broad Innovation Awards
Two teams of scientists have won the inaugural Eli and Edythe Broad Innovation Awards in Stem Cell Biology and Regenerative Medicine at USC. This year’s competition provides $120,000 each to the teams …
USC Stem Cell names second cohort of Broad Clinical Research Fellows
The second cohort of Broad Clinical Research Fellows is making strides towards finding stem cell-based therapies for lymphedema in cancer patients, large bone fractures and short bowel syndrome.
A gene called Prkci helps organize organisms and their organs
A gene called Prkci can point cells in the right direction, according to a new study in Developmental Biology. In the study, USC Stem Cell researcher In Kyoung Mah from the laboratory …
Dose of transplanted blood-forming stem cells affects their behavior
Unlike aspirin, bone marrow doesn’t come with a neatly printed label with dosage instructions. However, a new study published in Cell Reports provides clues about how the dose of transplanted bone marrow …
Key mutations may worsen hearing loss from the chemotherapy drug cisplatin
The chemotherapy drug cisplatin can kill cancer, but it can also kill the sensory cells of the inner ear — causing permanent hearing loss. This hearing loss is likely to be more severe …
Amplifying cell signals for potentially lower cost stem cell interventions
Editor’s Note: USC Stem Cell principal investigators Malcolm Snead and Yan Zhou were among the authors of “Supramolecular Nanofibers Enhance Growth Factor Signaling by Increasing Lipid Raft Mobility,” published on April 12, …
USC Stem Cell scientists enter the conversation about CRISPR
CRISPR-Cas9 is a gene-editing technique that enables scientists to disable, replace or modify sections of DNA. It allows for unprecedented precision and speed in the field of genome editing. It has been used to …
USC Stem Cell mini-symposium introduces next-generation researchers
The next generation of scientists is turning to stem cells to advance our understanding of systems ranging from the blood to the brain, from the liver to the lungs. Six of these …