Overview

USC Stem Cell scientists are advancing our understanding of how the body develops, maintains and repairs the muscles, cartilage and skeleton. They are also using stem cells to find new regenerative therapies for conditions ranging from difficult-to-heal bone fractures to muscle injury, from birth defects to arthritis.

Statistics

  • Arthritis and other rheumatoid conditions are the leading cause of disability in the US.
  • Approximately 6.3 million bone fractures occur each year in the US.
  • The most common fracture prior to age 75 is a wrist fracture. In those over age 75, hip fractures become the most common broken bone and can lead to permanent disability.
  • Between 10% and 55% of muscle injuries occur during sports activities.
  • Cleft lip and cleft palate are among the most common birth defects, affecting approximately one or two in a thousand babies.

Researchers

Muscles and Skeleton News

A gene control element for human outer ear development shows activity in the gills (green) of a 2-week old zebrafish (Image by Mathi Thiruppathy/Crump Lab/USC Stem Cell)

An earful of gill: USC Stem Cell study points to the evolutionary origin of the mammalian outer ear

The outer ear is unique to mammals, but its evolutionary origin has remained a mystery. According to a new study published in Nature from the USC Stem Cell lab of Gage Crump, …

Illustrations by Doug Chayka

Cell by cell: Rebuilding the body

USC researchers are revolutionizing how we treat disease by harnessing stem cells as “living medicine.” Anyone who’s healed from a cut or a scrape has witnessed the incredible regenerative power of stem …

A circular field of cells shows a gradient of patterns, with green spots decreasing in size as cell density increases.

By exerting “crowd control” over mouse cells, scientists make progress towards engineering tissues

Genes aren’t the sole driver instructing cells to build multicellular structures, tissues, and organs. In a new paper published in Nature Communications, USC Stem Cell scientist Leonardo Morsut and Caltech computational biologist …

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Muscles and Skeleton Videos

Dentistry student Julia Raulino Lima changes the lives of children with cleft palates.
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