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Dr. McMahon’s laboratory explores the mechanisms that maintain stem/progenitor cells and regulate their differentiation to mature cell types of different organ systems, particularly the kidney. By combining genetic and genomic approaches with high resolution imaging, his group is aiming to obtain a deeper understanding of stem cell biology and to develop novel therapeutic strategies for regenerative medicine.

Stories

From left, ChangHui Pak, Mayssa H. Mokalled, Naomi Habib, Frank Soldner and Alex J. Hughes (Photo by Cristy Lytal)

Next-generation stem cell scientists evidence strong nerves at USC mini-symposium

Five next-generation scientists got everyone’s neurons firing at the Junior Faculty Candidate Mini-symposium, hosted by USC’s Department of Stem Cell Biology and Regenerative Medicine on March 7.

From left, Andy McMahon and Ken Hallows (Photos by Phil Channing and courtesy of Ken Hallows)

World Kidney Day: USC’s Andy McMahon and Ken Hallows discuss kidney health and research

One in 10 people is affected by chronic kidney disease worldwide. On March 9, 2017, World Kidney Day shines a spotlight on the importance of kidneys and ways to reduce the impact …

From left: USC relay runners Valeria Mancino, Nils Lindstrom, Qing Liu, Jill McMahon, Kenneth Hallows, Andy McMahon, Daniel Rivera, Nuria Pastor-Soler, Veronica Haro-Acosta and Tracy Tran (Photo by Cristy Lytal)

Support the UKRO Los Angeles Marathon Charity Relay Team

One out of every two adults will develop chronic kidney disease during their lifetimes. To help these patients, USC scientists and clinicians are putting their feet to the task as part of …

The Stem Cell Day of Discovery event held at the USC Health Sciences Campus in Los Angeles, CA. February 4th, 2017. The event encourages students to learn more about STEM opportunities, including stem cell study and biotech, and helps demystify the fields and encourage student engagement. Photo by David Sprague

Five-hundred middle and high school students realized their “pluripotential” at the USC Stem Cell Day of Discovery

You can be anything you want—just like a stem cell. This was a key lesson for the 500 middle and high school students who attended the USC Stem Cell Day of Discovery …

Eli and Edythe Broad (Photo by Ben Gibbs)

The Broad Foundation gives a tenth birthday gift to the USC, UCLA and UCSF stem cell centers

Last Friday, scientists from USC, UCLA and UCSF gathered at a symposium to celebrate the tenth anniversary of their three stem cell research centers, established with support from Eli and Edythe Broad …

Denis Evseenko (Photo by Cristy Lytal)

Denis Evseenko receives $2.5 million from California Institute for Regenerative Medicine for osteoarthritis research

The Keck School of Medicine of the University of Southern California (USC) is one of four institutions to receive a multi-million dollar grant from the California Institute for Regenerative Medicine (CIRM) for …

Amgen's Bill Richards recently visited USC to provide an introduction to the company. (Photo by Cristy Lytal)

USC and Amgen launch the dialogues that drive discovery

Without collaboration between universities and pharmaceutical companies, scientists might never have developed essential medicines ranging from the antibiotic streptomycin in the 1950s to HIV medications in the 1990s. In recognition of the …

From left, Andy McMahon and Gage Crump (Photos by Phil Channing and the Crump Lab)

What I’m reading: Top picks from stem cell faculty members Andy McMahon and Gage Crump

Andy McMahon: Leigh Turner and Paul Knoepfler present a disturbing report in Cell Stem Cell on the growth of businesses marketing stem cell interventions in the US. Los Angeles is one “stem …

Lindsey Barske (Photo by Cristy Lytal)

USC Stem Cell scientist Lindsey Barske wins NIH Pathway to Independence Award

Years ago, Lindsey Barske pulled on a pair of tall rubber boots and began a journey that led from her college research experience on the muddy Alaskan tundra to her current postdoctoral …

From left, philanthropists Kin-Chung and Amy Choi with Andy McMahon, chair of the executive committee of USC Stem Cell (Photo by Steve Cohn)

Los Angeles wins bid to host international stem cell conference

In recognition of its growing stature as an incubator for the biosciences, Los Angeles will be the host city for the 2019 International Society for Stem Cell Research (ISSCR) Conference. With the …

From left, philanthropists Kin-Chung and Amy Choi with Andy McMahon, director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC (Photo by Steve Cohn)

The Choi Family’s gift inspires USC Stem Cell scientists to “Return to the Beginning”

Twenty-five years ago, philanthropists Kin-Chung and Amy Choi marked the occasion of their 25th wedding anniversary by purchasing the sculpture “Return to the Beginning,” by renowned Taiwanese artist Yuyu Yang. Now in …

Ophir Klein, professor at the University of California, San Francisco, delivered the keynote address. (Photo by Cristy Lytal)

Next generation of stem cell scientists detail their research from head to toe

The Stem Cell and Developmental Biology Retreat was a total body experience — covering organ systems ranging from the brain to the skeleton, from the kidney to the heart. Held on May …

New ways to regenerate bone emerge from the adult zebrafish face. (Image by Sandeep Paul and Seth Ruffins)

USC Stem Cell researchers use zebrafish to understand the role of cartilage in bone repair

Scientists have long believed that the processes required for embryonic development are recapitulated during the regeneration of damaged body parts, such as fractured bones. In a new study published in Development, USC …

Justin Ichida (Photo by Cristy Lytal)

USC Stem Cell scientist Justin Ichida named New York Stem Cell Foundation – Robertson Investigator

Some people see an award as remuneration for work well done. Upon being named a New York Stem Cell Foundation – Robertson Investigator, ALS researcher Justin Ichida sees his award as motivation …

Rendition of developing vertebrate bones. In their study, Hojo and colleagues address the transcriptional action and evolution of Sp7/Osx, a key determinant of vertebrate-restricted bone forming osteoblasts. (Painting by Kristen Chen; courtesy of Developmental Cell 2016)

USC Stem Cell study illuminates bone formation and vertebrate evolution

With the emergence of bone, the diversity of life expanded to encompass the bone-forming vertebrates, a group of species ranging from the tiny frog Paedophryne amauensis to the mighty blue whale. Bone …

From left, Edward Crandall, chair of the Department of Medicine, presents a UKRO award to Andy McMahon, chair of the Department of Stem Cell Biology and Regenerative Medicine. (Photo courtesy of HSC Communications office)

Four honored at UKRO benefit gala

University Kidney Research Organization (UKRO) honored USC academic and scientific leaders at its sixth gala dinner March 18 at The Beverly Hilton, with 300 attendees. This group of vocal champions of kidney …

Embryonic day 15.5 mouse kidney next to a 15.5 week human fetal kidney with SIX2 (cyan) marking the nephron progenitors and cytokeratin (red) highlighting the collecting duct system. Nuclei are in blue. (Image by Lori O'Brien)

USC researchers discover a key difference between mouse and human kidney stem cells

The best laid plans of mice and men are a bit different — at least when it comes to kidney development. Compared to a mouse, a human has nearly 100 times more nephrons, …

From left, Hsiang-Ying (Sherry) Lee, Sergei Doulatov, Leonardo Morsut, Alexander Pollen and Joan Font-Burgada (Photo by Cristy Lytal)

USC Stem Cell mini-symposium introduces next-generation researchers

The next generation of scientists is turning to stem cells to advance our understanding of systems ranging from the blood to the brain, from the liver to the lungs. Six of these …

Andy McMahon (Photo by Phil Channing)

UKRO benefit dinner to honor USC leaders

University Kidney Research Organization (UKRO) will honor a stellar group of USC academic and scientific leaders at its sixth gala dinner on March 18 at The Beverly Hilton. This group of vocal …

Motor neurons derived from an ALS patient (Image courtesy of the Ichida Lab)

USC announces winners of the Audrey E. Streedain Regenerative Medicine Initiative Awards

Two collaborative teams within USC Stem Cell are developing new approaches that could eventually help patients with heart disease, frontotemporal dementia and amyotrophic lateral sclerosis (ALS). The teams are the winners of …

Andrew P. McMahon, PhD, FRS