Dr. McMahon’s laboratory explores the mechanisms that maintain stem/progenitor cells and regulate their differentiation to mature cell types of different organ systems, particularly the kidney. By combining genetic and genomic approaches with high resolution imaging, his group is aiming to obtain a deeper understanding of stem cell biology and to develop novel therapeutic strategies for regenerative medicine.

Stories

“Tin Woman” Michaela Patterson, a postdoctoral scholar in the lab of Henry Sucov, studies heart regeneration — with no help from the Wizard of Oz. (Photo by Cristy Lytal); featured image for Halloween retreat showcases USC’s “scary smart” stem cell researchers

Halloween retreat showcases USC’s “scary smart” stem cell researchers

It was no tricks and all treats at the seventh annual retreat for the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, held at the university’s …

Graduate student Kimberley Babos explains how research at the Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC may help find effective drugs to treat amyotrophic lateral sclerosis. Military veterans are more likely than civilians to suffer from the devastating disease. (Photo by Steve Cohn); featured image for General David H. Petraeus gets a four-star tour of HSC

General David H. Petraeus gets a four-star tour of HSC

Petraeus—who also serves as the Judge Widney Professor at USC and Chairman of the KKR Global Institute—started his morning with a glimpse into the human brain. Faculty and students from the USC …

Lori O'Brien (Photo by Cristy Lytal)

USC stem cell researcher Lori O’Brien receives the first Broad Fellowship

What makes stem cells develop into kidneys? Lori O’Brien, a postdoctoral research associate in the laboratory of Andy McMahon, has received the first Broad Fellowship to help answer this question. O’Brien is …

"Stem cell research is important because it's cool to be a stem cell scientist!!!"

USC rolls out the cardinal carpet on Stem Cell Awareness Day

When asked why stem cell research matters, guests at this year’s Stem Cell Awareness Day gave many creative answers. “Because it has unlimited potential to treat human diseases.” “Because every part of …

Inaugural class of students in USC's master of science in stem cell biology and regenerative medicine program (Photo by Cristy Lytal)

USC welcomes its inaugural class of stem cell master’s students

USC welcomed its inaugural class of master’s students in stem cell biology and regenerative medicine to one of the first programs of its kind in the United States. To celebrate the launch …

Neil Segil, PhD, (right) gets a glimpse into retinal regeneration. (Photo by Cristy Lytal); featured image for USC stem cell PhD students present their blueprints for rebuilding the body

USC stem cell PhD students present their blueprints for rebuilding the body

Video by Alric Devotta The students in the new PhD program in Development, Stem Cells, and Regenerative Medicine recently presented some ideas that would give Dr. Frankenstein a run for his money. …

Human skull with sutures; featured image for USC, UCLA and UCSF put their heads together to find stem cell-based cures for craniofacial defects

USC, UCLA and UCSF put their heads together to find stem cell-based cures for craniofacial defects

One in every 2,000 babies is born with a skull that can’t grow normally. Various sections of these babies’ skulls are fused together at joints called sutures, constricting the developing brain and …

From right, Jing Liu, Andy McMahon and Sanjeev Kumar (Photo by Cristy Lytal); featured image for USC Stem Cell scientists lay a TRAP for disease

USC Stem Cell scientists lay a TRAP for disease

USC Stem Cell scientists have set a “mouse TRAP” to capture the early signs of kidney failure, as described by a recent study published in the Journal of Clinical Investigation. Their new …

Multi-well plate (Image courtesy of the National Institutes of Health); featured image for USC Stem Cell and the USC Norris Comprehensive Cancer Center accelerate drug discovery

USC Stem Cell and the USC Norris Comprehensive Cancer Center accelerate drug discovery

Three teams of USC stem cell researchers have won a coveted prize — the opportunity to test 3,000 drug candidates or chemicals for the potential to help patients. Two teams will focus …

Andy McMahon (Photo by Phil Channing); featured image for Andy McMahon and USC Stem Cell: From discoveries to cures

Andy McMahon and USC Stem Cell: From discoveries to cures

Video by Little Pictures How do fingers become fingers and not toes? How does the brain generate the correct number of neurons? How do the kidneys branch into the complex and elegant …

From right, philanthropist Kin-Chung (KC) Choi; USC’s stem cell research center director Andy McMahon and program director Qing Liu-Michael; and KC’s wife Amy Choi, daughter Lucia Choi-Dalton, daughter-in-law Queence Choi, and son and USC alumnus Henry Choi. (Photo by Cristy Lytal); featured image for USC Stem Cell celebrates the grand opening of the Choi Family Therapeutic Screening Facility

USC Stem Cell celebrates the grand opening of the Choi Family Therapeutic Screening Facility

How can scientists make more accurate predictions about which potential drugs will effectively treat disease — before launching expensive and laborious human clinical trials? USC’s new Choi Family Therapeutic Screening Facility offers …

Kidney (Image by Lori O'Brien/McMahon Lab)

USC launches one of California’s first master’s programs in stem cell biology and regenerative medicine

Video by Ryan Ball USC is pleased to offer one of the first master’s programs in stem cell biology and regenerative medicine in California. “The program gives students a unique entrée into …

Zebrafish skulls (watercolor by Kristin Chen); featured image for USC Roski and USC Stem Cell announce new collaboration

USC Roski and USC Stem Cell announce new collaboration

What happens when USC students — some studying art and design, others stem cell biology — examine zebrafish skulls under a microscope? It depends on who’s looking. During spring 2014, scientists at the …

Rong Lu and Min Yu (Photo by Cristy Lytal); featured image for Min Yu and Rong Lu explore how one bad cell spoils the bunch

Min Yu and Rong Lu explore how one bad cell spoils the bunch

Principal investigators Min Yu, MD, PhD, and Rong Lu, PhD, had plans to collaborate long before they were both recruited to the Department of Stem Cell Biology and Regenerative Medicine at the …

Andy McMahon, PhD, FRS (Photo by Cristy Lytal); featured image for Stem cells prove their potency at CHLA annual symposium

Stem cells prove their potency at CHLA annual symposium

The Saban Research Institute of Children’s Hospital Los Angeles Annual Symposium, held on Feb. 21, focused on the promise of regenerative medicine and cellular therapies — from curing HIV to building organs …

From left to right: Marvin Nelson, MD, MBA, Rex Moats, PhD, Brent Polk, MD, Elizabeth Garrett, JD, Scott Fraser, PhD, Carmen Puliafito, MD, MBA (Photo courtesy of Children's Hospital Los Angeles)

USC and Children’s Hospital Los Angeles launch imaging lab for translational research

With the launch of the Translational Biomedical Imaging Lab (TBIL), investigators at the University of Southern California (USC) and The Saban Research Institute of Children’s Hospital Los Angeles moved us closer to a …

Andy McMahon (Photo by Phil Channing); featured image for Hedgehog’s long snout finds a cure

Hedgehog’s long snout finds a cure

In 1993, the Human Frontier Science Program (HFSP) funded three researchers through one of the program’s prestigious Research Grants to work jointly on patterning of the mid-hindbrain region of the vertebrate embryo. …

Kidney (Image by Sanjeev Kumar); featured image for Winner of the October 2013 USC Stem Cell Image of the Month Contest

Winner of the October 2013 USC Stem Cell Image of the Month Contest

Dr. Andrew McMahon, Dr. Seth Ruffins and the judges of the USC Stem Cell Image of the Month contest would like to congratulate our October 2013 winner, Sanjeev Kumar, a postdoctoral research …

Mouse femur with enchondroma-like structure (Image by Lick Lai); featured image for USC study reveals a protein that keeps people—and their skeletons—organized

USC study reveals a protein that keeps people—and their skeletons—organized

Most people think that their planners or their iPhones keep them organized, when proteins such as liver kinase b1 (Lkb1) actually have a lot more to do with it. New research from …

Keynote speaker Clive Svendsen (right) and Director Andy McMahon; featured image for A Retreat from everything but stem cells

A Retreat from everything but stem cells

It wasn’t the pristine 27-hole course that drew more than 120 stem cell researchers from USC and beyond to the Desert Princess Golf Resort near Palm Springs. It was the sixth annual …