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Altered cells create an electrical “fire” in patients with epilepsy. (BioRender illustration by Aswathy Ammothumkandy/Bonaguidi Lab/USC Stem Cell); featured image for Newborn cells in the epileptic brain provide a potential target for treatment

Newborn cells in the epileptic brain provide a potential target for treatment

Over the years, everyone loses a few brain cells. A study led by scientists from USC Stem Cell and the USC Neurorestoration Center presents evidence that adults can replenish at least some …

Clockwise from top left, Miao Cui, Yulia Shwartz, Olena Zhulyn, and Kyle McCracken; featured image for Stem cell scientists explore the mysteries of regeneration at the Junior Faculty Candidate Seminar and Symposium

Stem cell scientists explore the mysteries of regeneration at the Junior Faculty Candidate Seminar and Symposium

How can we regenerate tissues that are damaged, lost or diseased in the human body? This was the central question driving the four scientists who presented their research at the Junior Faculty …

Rong Lu; featured image for For USC Stem Cell faculty member Rong Lu, science is in her blood

For USC Stem Cell faculty member Rong Lu, science is in her blood

When Rong Lu joined USC as an assistant professor of stem cell biology and regenerative medicine in 2014, she knew that earning tenure would figuratively require blood, sweat and tears. But after …

USC stem cell research center; featured image for Meet the scholarship winners in USC’s stem cell master’s program

Meet the scholarship winners in USC’s stem cell master’s program

For the second consecutive year, USC’s master’s program in stem cell biology and regenerative medicine has been able to offer scholarships to its talented students. Supported by the generosity of an anonymous …

Spine from a healthy mouse (left) and a mouse with genetically disrupted cartilage progenitor cells (Image by Dawei Geng and Tea Jashashvili); featured image for Arthritis-related gene also regenerates cartilage in joints and growth plates

Arthritis-related gene also regenerates cartilage in joints and growth plates

The IL-6 family of proteins has a bad reputation: it can promote inflammation, arthritis, autoimmune disease and even cancer. However, a new USC-led study published in Communications Biology reveals the importance of …

Confocal microscopy image of an adult zebrafish head with neural crest-derived cells in red. The Crump lab has used single-cell sequencing to understand how these cells build and repair the head skeleton, with implications for understanding human craniofacial birth defects and improving repair of skeletal tissues. (Image by Hung-Jhen Chen/Crump Lab); featured image for A crowning achievement in understanding head development

A crowning achievement in understanding head development

Cranial neural crest cells, or CNCCs, contribute to many more body parts than their humble name suggests. These remarkable stem cells not only form most of the skull and facial skeleton in …

Leukemia cells; featured image for How alike are the cancer cells from a single patient?

How alike are the cancer cells from a single patient?

Even within a single patient with cancer, there is a vast diversity of individual tumor cells, which display distinct behaviors related to growth, metastasis, and responses to chemotherapy. To carry out these …

Students; featured image for California’s stem cell agency awards USC $5 million to train scientists and clinicians

California’s stem cell agency awards USC $5 million to train scientists and clinicians

USC has been awarded a $5 million training grant from the California Institute for Regenerative Medicine (CIRM) to prepare PhD students, postdoctoral researchers, and clinical fellows for careers in stem cell research. …

Bell in the lab; featured image for Drug-like molecule points to novel strategies for cancer therapy

Drug-like molecule points to novel strategies for cancer therapy

A decade ago, genome sequencing revealed a big surprise: about 50 percent of human cancers are linked to mutations in what are known as epigenetic regulators, which control the activity of genes. …

Impromptu McMahon lab meeting; featured image for USC Stem Cell: An incubator for medicine of the 21st century

USC Stem Cell: An incubator for medicine of the 21st century

Just over a decade ago, USC was a university with a few scattered stem cell biologists, and a vision for total transformation. The university was committed to designing a unique “incubator” for …

mourning gecko; featured image for Aided by stem cells, a lizard regenerates a perfect tail for the first time in 250 million years

Aided by stem cells, a lizard regenerates a perfect tail for the first time in 250 million years

Lizards can regrow severed tails, making them the closest relative to humans that can regenerate a lost appendage. But in lieu of the original tail that includes a spinal column and nerves, …

By superimposing images of several of the kidney’s filtering units, known as nephrons, researchers can visualize how little these structures deviate from a stereotypical developmental trajectory.; featured image for USC-led study traces the blueprints for how human kidneys form their filtering units

USC-led study traces the blueprints for how human kidneys form their filtering units

When it comes to building a kidney, only nature possesses the complete set of blueprints. But a USC-led team of scientists has managed to borrow some of nature’s pages through a comprehensive …

The coronal suture contains stem cells (green).; featured image for Study of skull birth defect takes it from the top

Study of skull birth defect takes it from the top

Contrary to the popular song, the neck bone is actually connected to one of 22 separate head bones that make up the human skull. These plate-like bones intersect at specialized joints called …

Organ of Corti; featured image for USC Stem Cell scientists explore the latent regenerative potential of the inner ear

USC Stem Cell scientists explore the latent regenerative potential of the inner ear

Scientists from the USC Stem Cell laboratory of Neil Segil have identified a natural barrier to the regeneration of the inner ear’s sensory cells, which are lost in hearing and balance disorders. …

Scott Fraser by Noe Montes; featured image for USC Professor Scott E. Fraser redefines impossible problems

USC Professor Scott E. Fraser redefines impossible problems

USC Professor Scott E. Fraser is known for inventing new microscopes and other tools to observe living, developing embryos. But one of his lab’s most important pieces of technology filters coffee instead …

Inner ear sensory cells (left) and skin sensory cells from a one-day-old mouse; featured image for USC Stem Cell study points to a common ancestor for cells involved in hearing and touch

USC Stem Cell study points to a common ancestor for cells involved in hearing and touch

The sensory cells in the inner ear and the touch receptors in the skin actually have a lot in common, according to a new study from the USC Stem Cell laboratory of …

Megan McCain and family; featured image for USC Professor Megan McCain crafts an approach to tissue engineering

USC Professor Megan McCain crafts an approach to tissue engineering

Megan McCain has always liked using her hands to create things, ranging from art projects to human heart cells that grow on silicon chips. “I’ve always loved building things and doing crafts, …

A mouse kidney one month after acute injury. Cells that proliferated in response to the injury are shown in green. (Image by Louisa M. S. Gerhardt/McMahon Lab); featured image for The same cell type can help or hinder repair after acute kidney injury

The same cell type can help or hinder repair after acute kidney injury

The USC Stem Cell laboratory of Andy McMahon has identified a type of injured cell that might contribute to the transition from an acute kidney injury to chronic kidney disease, as described …

Unmesh Jadhav and Kimberly Gokoffski; featured image for The Baxter Foundation advances USC research on optic nerve disease and colorectal cancer

The Baxter Foundation advances USC research on optic nerve disease and colorectal cancer

For over 60 years, the Donald E. and Delia B. Baxter Foundation has supported innovative biomedical research at the Keck School of Medicine of USC, each year granting $100,000 awards to two …

kidney organoid; featured image for USC Stem Cell scientists make big progress in building mini-kidneys

USC Stem Cell scientists make big progress in building mini-kidneys

A team of scientists at the Keck School of Medicine of USC has created what could be a key building block for assembling a synthetic kidney. In a new study in Nature …