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Three USC researchers win $4.3 million in awards from California’s stem cell agency

Three scientists from Keck Medicine of USC have won grants exceeding $4.3 million from the California Institute for Regenerative Medicine (CIRM) for research that includes creating a temporary liver for patients, finding novel ways to treat immune disorders and blood diseases, and developing new animal models for heart failure, diabetes and neurodegenerative diseases. The grants, …

Pat Levitt (Photo courtesy of CHLA)

Neural development of 2-month-old infants shows effect of maternal stress

Story courtesy of Children’s Hospital Los Angeles A study of 70 mothers and their infants suggests that the impact of maternal stress on neurodevelopment is detectable by electroencephalography (EEG) at 2 months of age. The team of investigators, co-led by Pat Levitt, PhD, of Children’s Hospital Los Angeles, and Charles A. Nelson, PhD, of Boston …

CHLA team identifies developmental stage for eye tumor in children

Investigators at Children’s Hospital Los Angeles have been able to pinpoint the exact stage of development of the human retina, when cells can grow out of control and form cancer-like masses. The finding could open the door for future interventions in retinoblastoma (RB), a tumor of the retina that affects children under five years of …

Common psychiatric disorders share an overlapping genetic risk

Investigators found that many common psychiatric disorders are deeply connected on a genetic level, sharing specific genetic risk factors, underscoring the need to recognize shared dimensions of brain dysfunction, and develop new treatment strategies. Results of this investigation have been published in the June 22, 2018 issue of the journal, Science.

CHLA joins CureWorks collaborative to accelerate development of immunotherapy treatments for childhood cancers

Seattle Children’s, with participating members Children’s Hospital Los Angeles, Children’s National Health System and BC Children’s Hospital, has launched CureWorks, an international collaborative of leading academic children’s hospitals determined to accelerate the development of immunotherapy treatments for childhood cancer. CureWorks focuses on expanding immunotherapy trials and patient access around the world, as well as sharing …

Patt Levitt named inaugural Chief Scientific Officer at CHLA

Pat Levitt, PhD, has been named Vice President, Chief Scientific Officer and Director of The Saban Research Institute of Children’s Hospital Los Angeles.

Children’s Hospital Los Angeles joins national consortium to study use of stem cells in treating a rare cardiac defect

Children’s Hospital Los Angeles is announcing participation in the first-ever clinical trial using stem cells from umbilical cord blood to delay or even prevent heart failure in children born with a rare congenital heart defect that leaves them with half a heart.

Functional human tissue-engineered liver generated from stem and progenitor cells

A research team led by investigators at The Saban Research Institute of Children’s Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor cells. Tissue-engineered Liver (TELi) was found to contain normal structural components such as hepatocytes, bile ducts and blood vessels. The study has been published online in …

Stem cell researcher Tracy Grikscheit awarded $7.1 million by CIRM

Tracy C. Grikscheit, a principal investigator with USC Stem Cell and The Saban Research Institute of Children’s Hospital Los Angeles, has received a $7.1 million grant from the California Institute for Regenerative Medicine Translational Research program to develop a cellular therapy for the treatment of nerve disorders of the digestive system. These disorders, called enteric …

Zebrafish provide a novel model to study short bowel syndrome

USC Stem Cell investigators at Children’s Hospital Los Angeles (CHLA) are providing new hope for babies with short bowel syndrome (SBS) by developing a novel model of SBS in zebrafish, described in a paper published online on June 18 by the American Journal of Physiology-Gastrointestinal and Liver Physiology.

Tiny heart, big promise

The heart has its own dedicated blood supply, with coronary arteries that supply oxygen-rich blood to the heart and cardiac veins that remove deoxygenated blood. This system of vessels nourishes the heart, enabling it to pump blood to all the other organs and tissues of the body. Yet despite their critical importance, the process and …

Mammalian heart regenerative capacity depends on severity of injury

A new study by researchers at Children’s Hospital Los Angeles (CHLA) has shown that neonatal mouse hearts have varying regenerative capacities depending upon the severity of injury. Using cryoinjury — damaging the heart through exposure to extreme cold in order to mimic cellular injury caused by myocardial infarction — investigators found that neonatal mouse hearts …

Stem cells prove their potency at CHLA annual symposium

The Saban Research Institute of Children’s Hospital Los Angeles Annual Symposium, held on Feb. 21, focused on the promise of regenerative medicine and cellular therapies — from curing HIV to building organs such as kidneys and intestines. The panel of speakers included investigators from Children’s Hospital Los Angeles, USC, Children’s Hospital of Philadelphia, the University …

USC and Children’s Hospital Los Angeles launch imaging lab for translational research

With the launch of the Translational Biomedical Imaging Lab (TBIL), investigators at the University of Southern California (USC) and The Saban Research Institute of Children’s Hospital Los Angeles moved us closer to a day when diseases can be detected before symptoms appear.

Pat Levitt elected to Institute of Medicine

Pat Levitt, provost professor of pediatrics, neuroscience, psychiatry, psychology and pharmacy at the Keck School of Medicine of USC, was recently elected as a member into the prestigious Institute of Medicine (IOM), part of the National Academy of Sciences. The IOM is an independent non-governmental organization that provides unbiased, expert advice to policy makers and …

Magnetic treatment for high-risk neuroblastoma proves less than attractive

Removing tumor cells with a magnet? It may sound strange, but researchers at Children’s Hospital Los Angeles (CHLA) and their colleagues recently explored whether this technique can create better outcomes for patients with high-risk neuroblastoma, which carries a less than 50 percent chance of survival for children who are diagnosed. In a recent study published …

Ellin Kavanagh

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