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Three USC researchers win $4.3 million in awards from California’s stem cell agency

Three scientists from Keck Medicine of USC have won grants exceeding $4.3 million from the California Institute for Regenerative Medicine (CIRM) for research that includes creating a temporary liver for patients, finding novel ways to treat immune disorders and blood diseases, and developing new animal models for heart failure, diabetes and neurodegenerative diseases. The grants, …

LA smog (Image courtesy of the Ostrow School of Dentistry of USC)

Jian Xu investigates environmental pollution’s contribution to birth defects

Jian Xu hopes to better understand the mechanisms behind environmental toxins increasing the occurrence of birth defects in order to develop new treatments or even prevent craniofacial birth defects. Nearly 120,000 babies will be born with birth defects this year. While there are a number of causes — genetics and chromosomal issues, infections during pregnancy, …

Image courtesy of the Ostrow School of Dentistry of USC

Ostrow School of Dentistry of USC awarded research training grants from National Institutes of Dental and Craniofacial Research

The prestigious five-year training grants are meant to support tomorrow’s leading thinkers in craniofacial research as they launch their academic careers. The Ostrow School of Dentistry of USC has been awarded two training grants from the National Institute of Dental and Craniofacial Research to support nine PhD students and postdoctoral fellows, giving USC the distinction …

Image courtesy of the Ostrow School of Dentistry of USC

Could stem cell- or molecular-based treatment be the solution to temporomandibular joint disorders?

A new study, led by Amy Merrill-Brugger, could lead to new treatments for the common disorder. Our jaws allow us to talk, chew, swallow, sing and even yawn. All these activities require the temporomandibular joints, which connect the lower jaw to the base of the skull and drive its movement up and down and side …

Broken eggs

USC researchers regenerate skull tissue using stem cells and 3-D printed scaffolding in swine

Every year, surgeons perform more than 5,000 cranioplasties—surgeries that restore cranial defects—on patients who have experienced critical size cranial defects resulting from congenital defects, head trauma or tumor removals. Traditional materials used to correct these deficits have been bone grafts (from other humans or the patients themselves) or metal or plastic plates — none of …

Image courtesy of the Ostrow School of Dentistry of USC

A quantum leap

Ostrow jumps to fourth top-funded U.S. dental institution by the National Institute of Dental and Craniofacial Research. If a global pandemic was meant to slow researchers down in their quest for knowledge, no one told the research teams working in Ostrow’s lab spaces across both campuses. This year, the Herman Ostrow School of Dentistry of …

Is this the gamechanger we’ve been waiting for in craniosynostosis?

One of our every 2,500 infants born in the United States will suffer from craniosynostosis — a craniofacial defect caused by the premature fusion of the different bones that comprise the human skull. In a typically developing infant, these bones are separated by fibrous joints (think: “soft spots”) that allow for the skull’s continuing expansion …

(Image courtesy of Yang Chai)

USC-led research team shares 10 years’ progress in collecting data to push craniofacial science forward

It has been a little more than a decade since the National Institute of Dental and Craniofacial Research (NIDCR) launched FaceBase, a central repository for craniofacial datasets and tools meant to advance craniofacial science by fostering cooperation and collaboration around the globe. The endeavor, which represents contributions by researchers from more than two dozen universities …

Yang Chai

Yang Chai appointed University Professor

Associate Dean of Research Yang Chai PhD ’91, DDS ’96 has been appointed a University Professor, making history as the first faculty member to achieve such distinction at the Ostrow School of Dentistry of USC. The designation, held by fewer than 20 other faculty members across the university, is awarded very selectively to those whose …

C-DOCTOR

Center for Dental, Oral and Craniofacial Tissue and Organ Regeneration awarded $30-million grant

The studies seem like something straight out of science fiction. There’s one focused on using stem cells to regenerate skull bone for patients with skull defects. Another aims to develop a hydrogel patch that could reduce scarring and regenerate hair follicles and sweat glands in burn victims. Another looks to create a transdermal patch that …

USC researchers receive $12.5 million grant for craniofacial research data-sharing endeavor

Nearly half of all birth defects involve the face and skull and, for the most part, scientists remain unclear as to why most occur. To better serve families at risk for these conditions, scientists need a comprehensive and systematic understanding of how the faces of healthy children form and what goes wrong to cause common …

Janet Oldak

Moradian-Oldak receives Distinguished Scientist Award

Professor Janet Moradian-Oldak received a 2019 Basic Research in Biological Mineralization Award at the International Association for Dental Research’s (IADR) General Session and Exhibition in mid-June. The award — one of 17 Distinguished Scientist Awards — is one of the most prestigious awards bestowed by the IADR. It is meant to stimulate, encourage and recognize …

USC researchers draw closer to biological treatment for birth defect

Could we be one step closer to developing a biological treatment for craniosynostosis? Building upon a body of research that demonstrated that the premature fusion of skull bones — which can cause a host of problems as an infant’s brain continues to grow — is caused by a lack of stem cells, Associate Dean of …

Yang Chai elected to National Academy of Medicine

Yang Chai, associate dean of research at the Ostrow School of Dentistry of USC, has been elected to the National Academy of Medicine (NAM), a membership that is considered one of the highest honors in the fields of health and medicine. Chai is also a professor of stem cell biology and regenerative medicine, and the …

USC professor Malcolm Snead elected to AIMBE College of Fellows

Malcolm Snead, a professor at the Ostrow School of Dentistry of USC and a principal investigator with USC Stem Cell, has been elected to the American Institute for Medical and Biological Engineering (AIMBE) College of Fellows—an elite group of 1,500 distinguished bioengineers, representing the top two percent of the medical and biological engineering community.

USC researchers awarded $3.3 million NIDCR grant to find more effective treatment for common birth defect

It might surprise you to learn that your cranium is not one continuous smooth bone encasing your brain. It’s actually comprised of eight bones, separated by fibrous joints, to give your skull flexibility. That’s the reason babies have “soft spots” and your brain was able to continue growing unabated throughout childhood. With craniosynostosis—a birth defect …

USC Stem Cell researcher Yang Chai receives $2.1 million from the National Institute of Dental and Craniofacial Research

Yang Chai, associate dean of Research at the Ostrow School of Dentistry of USC, has just received $2.1 million to continue research that could one day allow scientists to use stem cells to regrow living tissue. The five-year grant, funded by the National Institute of Dental and Craniofacial Research, will give Ostrow researchers the opportunity …

Ostrow awarded NIDCR grant to establish tissue regeneration center

Tissue regeneration is about to become more fact than fiction, thanks to a $2 million grant that’s being divided among 10 research centers and universities, including the Ostrow School of Dentistry of USC. In a September 2014 request for applications, the National Institute for Dental and Craniofacial Research (NIDCR) challenged the research community to organize …

Researchers discover key player in enamel regeneration

USC researchers are closer than ever to being able to regrow enamel, thanks in part to a recent scientific discovery published in the latest issue of the journal Biomaterials. In the article, Malcolm Snead, who is chair of the division of biomedical sciences at the Herman Ostrow School of Dentistry of USC and a USC …

USC researchers move one step closer to natural tooth restorations

A rodent’s incisors never stop growing. It’s one of the reasons mice gnaw through cupboards, hamsters chomp mindlessly on metal cage bars and rats will chew through, well, just about anything. They need to wear down those ever-growing incisors, which, if left unchecked, could grow so long that the animal might starve. As unappealing as …

Discovery could lead to biological treatment for common birth defect

Throughout every human and animal’s body, stem cell populations are responsible for the growth, regeneration and repair of tissues. While the power of some types of stem cells is already being used in cutting-edge medicine, there is still much to discover before we truly unlock their potential. Researchers at the Ostrow School of Dentistry of …

John Hobbs

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