Dr. Chai’s laboratory is interested in early craniofacial development and malformations, including the molecular regulation of cranial neural crest cells. His laboratory has developed genetically engineered mouse models, and has made important discoveries about the mesenchymal stem cell (MSC) niche in the craniofacial region and about utilizing MSCs with 3D printed scaffolds for tissue regeneration.
Stories
Investigating the neighboring environment for stem cells
A long-held goal in dental research is to harness the power of stem cells to regenerate bone and dental tissue. But to do so, it’s important to fully understand the environment the …
Yang Chai appointed University Professor
Associate Dean of Research Yang Chai PhD ’91, DDS ’96 has been appointed a University Professor, making history as the first faculty member to achieve such distinction at the Ostrow School of …
Center for Dental, Oral and Craniofacial Tissue and Organ Regeneration awarded $30-million grant
The studies seem like something straight out of science fiction. There’s one focused on using stem cells to regenerate skull bone for patients with skull defects. Another aims to develop a hydrogel …
Cleft palate research continues to help patients
Associate Dean of Research Yang Chai PhD ’91, DDS ’96 has been awarded a five-year, nearly $2 million grant by the National Institute of Dental and Craniofacial Research (NIDCR) for research focused …
USC researchers receive $12.5 million grant for craniofacial research data-sharing endeavor
Nearly half of all birth defects involve the face and skull and, for the most part, scientists remain unclear as to why most occur. To better serve families at risk for these …
Ostrow researchers discover how genes for tooth roots turn on and off
To figure out how the body changes over time, researchers are increasingly looking to understand epigenetics, the study of changes in organisms caused by modification of gene expression rather than alteration of …
Yang Chai bridges the gap from the lab bench to the dental chair
As a young oral surgeon in China, Yang Chai often operated on babies born with cleft lips or palates. “You talk to the parents, and they were very emotional and trying find …
Researchers seek the root of tooth development
The lower two-thirds of a tooth are known as the root. Normally covered in bone, they anchor the tooth into the jaw. But the exact mechanisms and pathways that create the root …
USC researchers draw closer to biological treatment for birth defect
Could we be one step closer to developing a biological treatment for craniosynostosis? Building upon a body of research that demonstrated that the premature fusion of skull bones — which can cause …
USC researchers converge at the Interdisciplinary Stem Cell Symposium
“The field of stem cell biology is one of our great convergence opportunities,” said USC Provost Michael Quick, addressing an audience of biologists, chemists, physicists, engineers, clinicians and many others. This diverse …
Yang Chai elected to National Academy of Medicine
Yang Chai, associate dean of research at the Ostrow School of Dentistry of USC, has been elected to the National Academy of Medicine (NAM), a membership that is considered one of the …
At the retreat for USC’s stem cell department, the students become the masters
Students and trainees took center stage at the annual retreat for USC’s Department of Stem Cell Biology and Regenerative Medicine. They presented their latest research to the 180 stem cell scientists who …
Growing hope: New organs? Not yet, but stem cell research is getting closer
If you lose a limb, it’s lost for life. If you damage a kidney, you won’t grow a new one. And if you have a heart attack, the scars are there to …
Scientists get into detail at the retreat for USC’s stem cell department
“The process of disease is about detail,” said Larry Goldstein, the director of the stem cell program at the University of California, San Diego, and keynote speaker at the retreat for USC’s …
Stem cells may hold the key to helping patients with cleft palate
Every time we drink or breathe, the soft palate is hard at work. It acts like a trap door, allowing air to squeeze through or shutting so liquids can pass by. And …
The faculty job search just got easier, thanks to two USC Stem Cell postdocs
“I think we’re all here for the same reason,” said Michaela Patterson, a postdoc in the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC. “We’re considering …
Countdown to Commencement: Nelson Poliran Jr.—failure driven success
“Focus on one goal, be open minded and be persistent.” These are wise words from Nelson Poliran Jr., a standout scientist-in-training at USC. Poliran’s academic success hasn’t always come easily, though.
USC researchers close to identifying crucial gene for human cleft lip and palate
A group of researchers has found that three siblings born with cleft lip and palate share a common gene mutation associated with the birth defect. The gene intraflagellar transport 88 (IFT88) ensures …
Research group awarded $12 million to establish tissue regeneration center
A research team called C-DOCTOR (Center for Dental, Oral and Craniofacial Tissue and Organ Regeneration), initiated by the Ostrow School of Dentistry of USC, is one step closer to developing products that …
USC researchers awarded $3.3 million NIDCR grant to find more effective treatment for common birth defect
It might surprise you to learn that your cranium is not one continuous smooth bone encasing your brain. It’s actually comprised of eight bones, separated by fibrous joints, to give your skull …