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National Academy of Inventors elects four Keck School of Medicine of USC faculty as senior members

The National Academy of Inventors (NAI), a nonprofit member organization that encourages inventors in higher education, has announced that four researchers from the Keck School of Medicine of USC are part of …

Oliver Bell and Daniel Bsteh

USC Stem Cell study throws our understanding of gene regulation for a loop

The blueprint for human life lies within the DNA in the nucleus of each of our cells. In human cells, around six and a half feet of this genetic material must be …

Lab-grown 6-month-old human Purkinje cell (Image by Alexander Atamian and Marcella Birtele/Quadrato Lab)

USC Stem Cell scientists develop a game-changing organoid model to study human cerebellar development and disease

In a first for USC Stem Cell scientists, the laboratory of Giorgia Quadrato, an assistant professor of stem cell biology and regenerative medicine, has pioneered a novel human brain organoid model that …

Building an Incubator for Medicine of the 21st Century

Building an Incubator for Medicine of the 21st Century

USC Stem Cell is pleased to introduce our new publication. We hope you’ll enjoy reflecting back on our history, while looking ahead to the transformative times to come. Read now at https://stemcell.keck.usc.edu/wp-content/themes/stemcell/incubator.

Two sculptures representing a human neuron and a radial glia cell, inspired by the findings published by the Quadrato Lab in Nature Neuroscience. (Sculptures by Jane Kwak; photo by Sergio Bianco)

The Autism-linked gene SYNGAP1 could impact early stages of human brain development, USC study reveals

New research shows that variants of SYNGAP1, a gene previously thought only to affect synapses between mature neurons, may disrupt early development in the brain’s cortex, a region involved in higher-order cognitive …

Justin Ichida (Photo by Ben Gibbs)

USC Stem Cell research from Justin Ichida’s lab advances toward clinical development for ALS, following a license agreement between companies Takeda and AcuraStem

USC Stem Cell scientist Justin Ichida has learned to inhabit two worlds: the university where his lab makes discoveries, and the companies that can help commercialize these discoveries into new treatments for …

(Image courtesy of the Chen Lab)

A new way to treat craniosynostosis?

Craniosynostosis is a birth defect in which the bones in a baby’s skull fuse too early — before the brain is fully formed. It happens in 1 in nearly 2,200 births and …

(Image courtesy of iStock)

$2 million grant boosts technological advancements in cutting-edge cell therapy manufacturing facility

The Keck School of Medicine of USC has received $2 million from the California Institute of Regenerative Medicine (CIRM) to further augment its newly launched cGMP Laboratory, a state-of-the-art facility designed to …

Amy Merrill-Brugger (Photo by Phil Channing)

Inside the hunt to understand developing baby skulls

If you’ve ever held a baby, you probably remember soft spots on their heads — space for the developing skulls to grow around the brain. When the system works correctly, it leaves …

Ksenia Gnedeva (Photo by Chris Shinn)

Breaking the sound barrier: Ksenia Gnedeva’s transformative research on growth and regeneration in the inner ear sensory organs

Some children dream of growing up to be a ballerina or an astronaut, but Ksenia Gnedeva always knew she wanted to be a biologist. “I remember receiving a microscope for my sixth …

Normal vision and view with AMD

USC-supported startup receives major grant for clinical trial of a promising eye treatment

A stem cell patch developed by USC researchers for patients with macular degeneration will soon be tested in a phase 2b clinical trial. This latest milestone in the patch’s development was made …

Neural stem cells derived from patients with ALS or frontotemporal dementia (Image by Eric Hendricks/Ichida Lab)

ALS and frontotemporal dementia show origins in utero, according to evidence from mice and patient-derived stem cells

Even though neurodegenerative diseases often strike in middle age or later, patients could have structural differences in their brains that arise before birth. In a new study in Cell Reports, USC Stem …

Rows of sensory hearing cells (green) next to supporting cells (red) in the inner ear of a mouse (Image by John Duc Nguyen and Juan Llamas/Segil Lab)

USC Stem Cell mouse studies tune into hearing regeneration

A deafened adult cannot recover the ability to hear, because the sensory hearing cells of the inner ear don’t regenerate after damage. In two new studies, partially funded by the National Institutes …

Yang Chai (Photo by Chris Shinn)

University Professor Yang Chai wins 2023 Harvard School of Dental Medicine’s Paul Goldhaber Award

Yang Chai, the associate dean of research for the Ostrow School of Dentistry of USC, has been awarded the 2023 Paul Goldhaber Award by the Harvard School of Dental Medicine. The highest …

Louise Menendez

USC Stem Cell faculty member Louise Menendez helps students realize their pluri-potential

Louise Menendez, the newest assistant professor in USC’s Department of Stem Cell Biology and Regenerative Medicine, credits her mother as her first role model for career success. Both of Menendez’s parents work …

Berenice Benayoun (Photo by Charles Camarda)

USC Professor Bérénice Benayoun receives grant to study menopause and ovarian aging

Bérénice Benayoun, assistant professor of gerontology at the USC Leonard Davis School, received a $200,000 grant from the Chan Zuckerberg Initiative (CZI). The funding will support Benayoun’s work in understanding the molecular …

Pinchas Cohen (Image courtesy of the USC Davis School of Gerontology)

Pinchas Cohen named USC Distinguished Professor

Pinchas Cohen, dean of the USC Leonard Davis School of Gerontology, has been named a Distinguished Professor, an honor that is granted to a select group of USC academics each year. “These …

Human induced motor neurons. Motor neurons are green, and neurons are purple. (Image courtesy of the Ichida Lab)

USC Stem Cell-led studies point the way to broadly effective treatments for ALS

Each year in the U.S., 5,000 patients receive a diagnosis of ALS, an incurable neurodegenerative disease that will likely kill them within two to five years. In the quest to find a …

The new lab’s collaborative structure promises to play a key role in the development of groundbreaking advancements in health care. (Photo/Steve Cohn)

New USC/CHLA cGMP Lab opens to accelerate next-generation cell therapy

A new laboratory designed to advance early-stage research into lifesaving, commercially viable therapies was celebrated on the USC Health Sciences Campus Tuesday night. Housed at the USC Norris Comprehensive Cancer Center, the …

Neuronal specification is compromised in Zfp462 deleted cells. Immunofluorescence images of wildtype (WT) and Zfp462 deleted (Zfp462 KO) cells during neural differentiation. The neuronal lineage marker SOX1 is shown in green and the endodermal lineage marker FOXA2 is in magenta. Non-neural cells are detected during the neural differentiation of Zfp462 KO cells. © Bell Lab / NCB /IMBA.

Weiss-Kruszka syndrome and the failure to establish neuronal identity

Weiss-Kruszka syndrome is a rare neurodevelopmental disorder characterized by craniofacial anomalies, developmental delay, and autistic features. Researchers at the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences and the …