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In the neural stem cells at the left, the protein SMEK1 (red) is localized in the nucleus (blue), while the protein PAR3 (green) is in the cytoplasm. When neural stem cells divide, as in the cells at the right, SMEK1 moves to the cytoplasm, where it regulates PAR's activity. (Image courtesy of Wange Lu)

USC researchers apply brainpower to understanding neural stem cell differentiation

How do humans and other mammals get so brainy? USC researcher Wange Lu, PhD, and his colleagues shed new light on this question in a paper published in Cell Reports on October …

Pat Levitt (Photo courtesy of Children's Hospital Los Angeles)

Pat Levitt elected to Institute of Medicine

Pat Levitt, provost professor of pediatrics, neuroscience, psychiatry, psychology and pharmacy at the Keck School of Medicine of USC, was recently elected as a member into the prestigious Institute of Medicine (IOM), …

Embryonic stem cells that have differentiated into neurons (Image by In Kyoung Mah/Mariani Lab)

Winner of the September 2013 USC Stem Cell Image of the Month Contest

Dr. Andrew McMahon, Dr. Seth Ruffins and the judges of the USC Stem Cell Image of the Month contest would like to congratulate our September 2013 winner, In Kyoung Mah, a graduate …

MIcroscopy related to Alzheimer's disease

USC professors receive NIH funding for clinical trial of Alzheimer’s drug

USC Professors Roberta Diaz Brinton of the USC School of Pharmacy and Lon Schneider of the Keck School of Medicine of USC are principal investigators of a newly funded study from the …

Embryonic stem cells (Image/courtesy of Qi-Long Ying)

USC researcher reveals how to better master stem cells’ fate

USC scientist Qi-Long Ying and a team of researchers have long been searching for biotech’s version of the fountain of youth — ways to encourage embryonic stem cells (ESCs) and epiblast stem …

Judy Villablanca (Photo courtesy of Children's Hospital Los Angeles)

Magnetic treatment for high-risk neuroblastoma proves less than attractive

Removing tumor cells with a magnet? It may sound strange, but researchers at Children’s Hospital Los Angeles (CHLA) and their colleagues recently explored whether this technique can create better outcomes for patients …

Speakers at the first first Zilkha Mini­Symposium on Alzheimer’s Research at USC covered a variety of topics on the devastating disease. Pictured here (left to right) are Christian Pike, PhD, associate professor, USC Davis School of Gerontology; Hong-Wei Dong, MD, PhD, associate professor, department of neurology; Roberta Brinton, PhD, R. Pete Vanderveen Chair in Therapeutic Discovery & Development; Maria Carrillo, vice president, medical and scientific relations, Alzheimer’s Association; Russell Jacobs, PhD, member, Zilkha Neurogenetic Institute; Arthur W. Toga, PhD, Provost Professor of Ophthalmology, Neurology, Psychiatry and the Behavioral Sciences, Radiology and Engineering; director of the USC Institute for Neuroimaging and Informatics; Paul Thompson, PhD, professor of ophthalmology, neurology, psychiatry and the behavioral sciences, radiology and engineering; Helena Chui, MD, Raymond and Betty McCarron Chair in Neurology; Lon Schneider, MD, director, USC Alzheimer Disease Research and Clinical Center; Berislav Zlokovic, MD, PhD, director, Zilkha Neurogenetic Institute; and Scott Fraser, PhD, Provost Professor of Biological Sciences and Biomedical Engineering. (Photo by Amy E. Hamaker)

First Zilkha Alzheimer’s Mini-Symposium examines vascular system connections

Alzheimer’s disease is the sixth leading cause of death in the United States, and more than five million Americans live with the disease, according to the Alzheimer’s Association. Conquering Alzheimer’s was the …

From left, Andrew P. McMahon, director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, with Yong Chen’s son Gary and researcher Qi-Long Ying (Photo by Cristy Lytal)

Businessman invests in stem cell research at USC

Chinese businessman Yong Chen has pledged $1 million to USC stem cell researcher Qi-Long Ying to support his future “eureka moments.” “When I talked to Mr. Chen, I told him that groundbreaking …

Neural stem cells derived from self-renewing mouse embryonic stem cells (Image courtesy of Qi-Long Ying)

A special protein helps embryonic stem cells keep their options open

In the ongoing quest to understand how embryonic stem cells (ESCs) retain their ability to differentiate into virtually any kind of cell, USC faculty member Qi-Long Ying and a team of researchers …

From left, Gage Crump, Jay R. Lieberman and Francesca Mariani (Photo by Cristy Lytal)

USC announces winners of first Regenerative Medicine Initiative awards

Three newly assembled disease teams within USC Stem Cell will take the early steps this year that might lead to future stem-cell based therapies for certain forms of deafness, bone defects and …

This embryonic mouse at day 10.5 has a special glow thanks to the fluorescent labeling of its neurofilaments, which are major structural element of neurons. The picture won the July 2013 Image of the Month contest at the Eli and Edythe Broad Center for Rengerative Medicine and Stem Cell Research at USC. (Image by Elisabeth Rutledge, PhD student in the lab of Andrew McMahon)

Winner of the July 2013 USC Stem Cell Image of the Month Contest

Dr. Andrew McMahon, Dr. Seth Ruffins and the judges of the USC Stem Cell Image of the Month contest would like to congratulate our July 2013 winner, Elisabeth Rutledge, a PhD student …

MIcroscopy related to Alzheimer's disease

USC professor presents Alzheimer’s findings at international conference

USC School of Pharmacy Professor Roberta Diaz Brinton, holder of the R. Pete Vanderveen Chair in Therapeutic Discovery and Development, presented her work on Allopregnanolone and the phase 1 trial that will …

Wange Lu (Photo by Chris Shinn)

USC study sheds light on stem cell reprogramming

Researchers are learning how to turn regular cells into stem cells, a process called reprogramming. However, some of the mechanisms of the process remain unknown, such as why only a small proportion of the cells can be reprogrammed. Researchers have at least part of the answer: the structure of genes.

Norman Arnheim

Common genetic disease linked to father’s age

Scientists at USC have unlocked the mystery of why new cases of the genetic disease Noonan syndrome are so common—a mutation, which causes the disease, disproportionately increases a normal father’s production of …

From left to right: Mr. K.V. Kumar, Dr. Andy McMahon, Sir John Gurdon and Mr. Jonathan Thomas (Photo courtesy of USC)

Interview with Sir John Gurdon

Sir John Gurdon, a Nobel Prize-winning biologist whose experiments in the field of cloning laid the foundation for modern stem cell research, visited the USC Health Sciences Campus on May 16. He …

Sir John Gurdon won the 2012 Nobel Prize in Physiology or Medicine for laying the groundwork for stem cell research. (Photo courtesy of John Gurdon)

Nobel Laureate discusses history of cloning

Cells can be stubborn things. A skin cell resists changing into a liver cell, and a heart cell wants to remain a heart cell. But with the right kind of manipulation, they …

Sir John Gurdon won the 2012 Nobel Prize in Physiology or Medicine for laying the groundwork for stem cell research. (Photo courtesy of John Gurdon)

Nobel laureate to speak on stem cells at HSC

Nobel laureate Sir John Gurdon will speak on “From Nuclear Transplantation to Prospects for Cell Replacement” on May 16 at noon in the Aresty Auditorium of the Harlyne J. Norris Cancer Research …

Andy McMahon (Photo by Phil Channing)

Probing the power of stem cells

Piece by missing piece, scientists at the Keck School of Medicine of USC are deciphering the powerful gene regulatory circuit that maintains and controls the potential of embryonic stem cells (ESCs) to …

Dr. Wange Lu and Fan Gao (Photo courtesy of USC)

Unraveling the mystery of pluripotency in embryonic stem cells

Using advanced sequencing technology, USC Stem Cell faculty member Wange Lu, in collaboration with Kai Wang of the USC Zilkha Neurogenetics Institute, explores the mystery of pluripotency by mapping out the interaction …

Andy McMahon (Photo by Phil Channing)

McMahon discusses central role of stem cell biology in medicine of the future

USC scored a major coup when it brought scientist Andrew McMahon to the Keck School of Medicine of USC from Harvard University, where he had served for almost two decades as a …