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Three USC researchers win $4.3 million in awards from California’s stem cell agency

Three scientists from Keck Medicine of USC have won grants exceeding $4.3 million from the California Institute for Regenerative Medicine (CIRM) for research that includes creating a temporary liver for patients, finding novel ways to treat immune disorders and blood diseases, and developing new animal models for heart failure, diabetes and neurodegenerative diseases. The grants, …

Layers of healthy human kidney cells (visible as red and green in fluorescent image) form a working filter in the new model developed by Dr. Perin and Dr. Da Sacco in the GOFARR Lab.

CHLA scientists develop first physiologically-accurate in vitro model of the human kidney glomerulus

Story courtesy of Children’s Hospital Los Angeles Kidneys work to constantly filter blood and remove toxins from the body. Conditions such as chronic kidney disease (CKD) are characterized by a reduced ability to perform this essential function. CKD incidence is growing and more than 1.4 million individuals depend on dialysis or kidney transplant for survival. …

New cellular approach found to control progression of chronic kidney disease

Researchers have demonstrated for the first time that extracellular vesicles—tiny protein-filled structures—isolated from amniotic fluid stem cells (AFSCs) can be used to effectively slow the progression of kidney damage in mice with a type of chronic kidney disease. The findings, by a research team at the Saban Research Institute of Children’s Hospital Los Angeles, provide …

Fasting-mimicking diet may reverse diabetes in mice

By Beth Newcomb A diet designed to imitate the effects of fasting appears to reverse diabetes, a new USC-led study shows. The fasting-like diet promotes the growth of new insulin-producing pancreatic cells that reduce symptoms of type 1 and type 2 diabetes in mice, according to the study on mice and human cells led by …

Andy McMahon and USC Stem Cell: From discoveries to cures

Video by Little Pictures How do fingers become fingers and not toes? How does the brain generate the correct number of neurons? How do the kidneys branch into the complex and elegant structure that filters the blood and regulates its pressure? Renowned biologist Andy McMahon spent decades unlocking these and other mysteries of embryonic development …

Stem cells prove their potency at CHLA annual symposium

The Saban Research Institute of Children’s Hospital Los Angeles Annual Symposium, held on Feb. 21, focused on the promise of regenerative medicine and cellular therapies — from curing HIV to building organs such as kidneys and intestines. The panel of speakers included investigators from Children’s Hospital Los Angeles, USC, Children’s Hospital of Philadelphia, the University …

Keck School researchers to speak at World Stem Cell Summit

Faculty researchers and clinicians from the Keck School of Medicine of USC are among more than 170 speakers who will discuss their efforts to zero in on disease cures at an international conference organized to highlight the progress of stem cell research. The World Stem Cell Summit 2011 takes place Oct. 3–5 at the Pasadena …

Laura Perin, PhD

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