Left to right: Roger De Filippo, MD, Stefano Da Sacco, PhD, Laura Perin, PhD

Children’s Hospital Los Angeles receives NIH awards for research into combating childhood kidney failure

In children with progressive chronic kidney disease (CKD), loss of kidney function is mostly irreversible. The GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology at Children’s Hospital Los Angeles …

Wilms tumor team

A bench-to-bedside approach to Wilms tumor

Stefano Da Sacco, PhD, calls Wilms tumor “an underdog” in the research world. “If you go to the American Urological Association or other meetings, there aren’t many presentations or discussions about Wilms …

Layers of healthy human kidney cells (visible as red and green in fluorescent image) form a working filter in the new model developed by Dr. Perin and Dr. Da Sacco in the GOFARR Lab.

CHLA scientists develop first physiologically-accurate in vitro model of the human kidney glomerulus

Story courtesy of Children’s Hospital Los Angeles Kidneys work to constantly filter blood and remove toxins from the body. Conditions such as chronic kidney disease (CKD) are characterized by a reduced ability …

Laura Perin (Photo courtesy of CHLA)

New cellular approach found to control progression of chronic kidney disease

Researchers have demonstrated for the first time that extracellular vesicles—tiny protein-filled structures—isolated from amniotic fluid stem cells (AFSCs) can be used to effectively slow the progression of kidney damage in mice with …

Valter Longo (Photo by John Skalicky)

Fasting-mimicking diet may reverse diabetes in mice

By Beth Newcomb A diet designed to imitate the effects of fasting appears to reverse diabetes, a new USC-led study shows. The fasting-like diet promotes the growth of new insulin-producing pancreatic cells …

Andy McMahon (Photo by Phil Channing)

Andy McMahon and USC Stem Cell: From discoveries to cures

Video by Little Pictures How do fingers become fingers and not toes? How does the brain generate the correct number of neurons? How do the kidneys branch into the complex and elegant …

Andy McMahon, PhD, FRS (Photo by Cristy Lytal)

Stem cells prove their potency at CHLA annual symposium

The Saban Research Institute of Children’s Hospital Los Angeles Annual Symposium, held on Feb. 21, focused on the promise of regenerative medicine and cellular therapies — from curing HIV to building organs …

Elizabeth Fini (Photo courtesy of USC)

Keck School researchers to speak at World Stem Cell Summit

Faculty researchers and clinicians from the Keck School of Medicine of USC are among more than 170 speakers who will discuss their efforts to zero in on disease cures at an international …

Laura Perin, PhD