Nils Lindström

Nils Lindström, PhDAssistant Professor, Stem Cell Biology and Regenerative Medicine


Dr. Lindstrom’s lab studies the molecular mechanisms that control how progenitors that exist during development differentiate into the broad range of cell types that underpin adult organ function. The lab integrates single-cell omic approaches with new microscopy and computational tools to understand how genetic changes cause abnormal differentiation in the kidney and model these genetic changes in the renal stem-cell derived organoid with the aim of identifying new treatments for kidney disease.

Stories

; featured image for Wnt happens in kidney development?

Wnt happens in kidney development?

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A pair of USC Stem Cell mouse studies detail how progenitor cells self-renew, differentiate, and aggregate into early kidney structures, offering insights for the creation of stem cell-based artificial kidneys. A group …

In specialized kidney cells that filter the blood (podocytes), both mouse and human cells express the gene MAFB (red) but the human kidney disease associated gene PLA2R1 is only active in human cells (green). (Image by Sunghyun Kim/McMahon lab); featured image for USC Stem Cell study maps how genes instruct kidneys to develop differently in mice and humans

USC Stem Cell study maps how genes instruct kidneys to develop differently in mice and humans

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How similar is kidney development in humans and in the lab mice that form the foundation of basic medical research? In a new study published in Developmental Cell, USC Stem Cell scientists …

Lab grown human nephron progenitor cells (Image by Biao Huang/Li Lab); featured image for USC-led study introduces a new and improved way to grow the cells that give rise to the kidney’s filtration system

USC-led study introduces a new and improved way to grow the cells that give rise to the kidney’s filtration system

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In a new study published in Cell Stem Cell, USC scientists report significant progress in cultivating nephron progenitor cells (NPCs), the cells destined to form the kidney’s filtration system, the nephrons. NPCs …

Kidney organoids with proximal tubules (Image by Jack Schnell/Lindström Lab); featured image for $3.95 million CIRM grant establishes USC ASCEND Center to make stem cell-derived organ models accessible to all

$3.95 million CIRM grant establishes USC ASCEND Center to make stem cell-derived organ models accessible to all

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To democratize access to lab-grown organ-like structures known as organoids and other advanced stem cell and transcriptomic technologies, USC will launch the CIRM ASCEND Center, dedicated to “Advancing Stem Cell Education and …

Building an Incubator for Medicine of the 21st Century; featured image for Building an Incubator for Medicine of the 21st Century

Building an Incubator for Medicine of the 21st Century

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USC Stem Cell is pleased to introduce our new publication. We hope you’ll enjoy reflecting back on our history, while looking ahead to the transformative times to come. Read now at https://stemcell.keck.usc.edu/wp-content/themes/stemcell/incubator.

From left, Fokion Glykofrydis, Nils Lindström, Leonardo Morsut, and Connor Fausto (Photo by Sergio Bianco); featured image for USC Stem Cell’s journey towards 1,000 mini-kidneys begins with $1 million from KidneyX

USC Stem Cell’s journey towards 1,000 mini-kidneys begins with $1 million from KidneyX

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To help patients in need of transplants, artificial kidneys would have to function like their natural counterparts, but they wouldn’t necessarily have to look like them. With a new $1 million prize …

Kuo-Chang (Ted) Tseng from the Crump Lab and Michelle Hung from the Ichida Lab enjoy a beachside brainstorm.; featured image for Scientists feel the sand between their toes at the retreat for USC’s stem cell department

Scientists feel the sand between their toes at the retreat for USC’s stem cell department

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A pair of young scientists picked up a piece of driftwood and thoughtfully traced a series of letters in the wet sand of Ventura Beach. The word “microglia”—referring to the immune cells …

By superimposing images of several of the kidney’s filtering units, known as nephrons, researchers can visualize how little these structures deviate from a stereotypical developmental trajectory.; featured image for USC-led study traces the blueprints for how human kidneys form their filtering units

USC-led study traces the blueprints for how human kidneys form their filtering units

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When it comes to building a kidney, only nature possesses the complete set of blueprints. But a USC-led team of scientists has managed to borrow some of nature’s pages through a comprehensive …

Tracy Tran; featured image for USC Stem Cell PhD student Tracy Tran: Celebrating the journey of a budding developmental biologist

USC Stem Cell PhD student Tracy Tran: Celebrating the journey of a budding developmental biologist

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As a child in Vietnam, Tracy Tran helped her family run a small business importing porcelain products from China and assumed she would follow in their footsteps. Neither of her parents had …

Nils Lindström, PhD