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Dr. Chai’s laboratory is interested in early craniofacial development and malformations, including the molecular regulation of cranial neural crest cells. His laboratory has developed genetically engineered mouse models, and has made important discoveries about the mesenchymal stem cell (MSC) niche in the craniofacial region and about utilizing MSCs with 3D printed scaffolds for tissue regeneration.

Stories

USC researcher Yang Chai has received another five-year grant to bolster his research into the causes of one of the most common congenital birth defects.

Cleft palate research continues to help patients

Associate Dean of Research Yang Chai PhD ’91, DDS ’96 has been awarded a five-year, nearly $2 million grant by the National Institute of Dental and Craniofacial Research (NIDCR) for research focused …

Craniofacial conditions, or malformation of the head and face, affect approximately 600,000 people in the United States, according to Children’s National Health System. (Photos courtesy of iStock)

USC researchers receive $12.5 million grant for craniofacial research data-sharing endeavor

Nearly half of all birth defects involve the face and skull and, for the most part, scientists remain unclear as to why most occur. To better serve families at risk for these …

The discovery could change the way dental implants are placed, allowing dentists to regenerate tooth roots that better integrate with jaw bone structures.

Ostrow researchers discover how genes for tooth roots turn on and off

To figure out how the body changes over time, researchers are increasingly looking to understand epigenetics, the study of changes in organisms caused by modification of gene expression rather than alteration of …

Yang Chai (Photo by Chris Shinn)

Yang Chai bridges the gap from the lab bench to the dental chair

As a young oral surgeon in China, Yang Chai often operated on babies born with cleft lips or palates. “You talk to the parents, and they were very emotional and trying find …

How the roots of teeth develop has long been a mystery. Professor Yang Chai aims to change that — and eventually regrow the roots of teeth.

Researchers seek the root of tooth development

The lower two-thirds of a tooth are known as the root. Normally covered in bone, they anchor the tooth into the jaw. But the exact mechanisms and pathways that create the root …

Children with craniosynostosis could one day be treated with a biological intervention.

USC researchers draw closer to biological treatment for birth defect

Could we be one step closer to developing a biological treatment for craniosynostosis? Building upon a body of research that demonstrated that the premature fusion of skull bones — which can cause …

The Interdisciplinary Stem Cell Symposium sparked collaborations. (Photo by Sergio Bianco)

USC researchers converge at the Interdisciplinary Stem Cell Symposium

“The field of stem cell biology is one of our great convergence opportunities,” said USC Provost Michael Quick, addressing an audience of biologists, chemists, physicists, engineers, clinicians and many others. This diverse …

Yang Chai (Photo courtesy of the Ostrow School of Dentistry of USC)

Yang Chai elected to National Academy of Medicine

Yang Chai, associate dean of research at the Ostrow School of Dentistry of USC, has been elected to the National Academy of Medicine (NAM), a membership that is considered one of the …

Note to self (Photo by Sergio Bianco)

At the retreat for USC’s stem cell department, the students become the masters

Students and trainees took center stage at the annual retreat for USC’s Department of Stem Cell Biology and Regenerative Medicine. They presented their latest research to the 180 stem cell scientists who …

Kidney (Image by Lori O'Brien/Andy McMahon Lab, illustration by Mira Nameth)

Growing hope: New organs? Not yet, but stem cell research is getting closer

If you lose a limb, it’s lost for life. If you damage a kidney, you won’t grow a new one. And if you have a heart attack, the scars are there to …

Larry Goldstein, the director of the stem cell program at the University of California, San Diego, and keynote speaker at the retreat for USC’s Department of Stem Cell Biology and Regenerative Medicine (Photo by Cristy Lytal)

Scientists get into detail at the retreat for USC’s stem cell department

“The process of disease is about detail,” said Larry Goldstein, the director of the stem cell program at the University of California, San Diego, and keynote speaker at the retreat for USC’s …

Yang Chai (Photo courtesy of the Ostrow School of Dentistry of USC)

Stem cells may hold the key to helping patients with cleft palate

Every time we drink or breathe, the soft palate is hard at work. It acts like a trap door, allowing air to squeeze through or shutting so liquids can pass by. And …

From left, Gage Crump, Min Yu, Yang Chai, Joseph T. Rodgers and Denis Evseenko—all faculty in the Department of Stem Cell Biology and Regenerative Medicine—led a panel discussion about “Preparing for the faculty job market.” (Photo by Cristy Lytal)

The faculty job search just got easier, thanks to two USC Stem Cell postdocs

“I think we’re all here for the same reason,” said Michaela Patterson, a postdoc in the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC. “We’re considering …

From left, Nelson Poliran Jr. and Charles Bramlett (Photo by Cristy Lytal)

Countdown to Commencement: Nelson Poliran Jr.—failure driven success

“Focus on one goal, be open minded and be persistent.” These are wise words from Nelson Poliran Jr., a standout scientist-in-training at USC. Poliran’s academic success hasn’t always come easily, though.

Yang Chai (Photo courtesy of the Ostrow School of Dentistry of USC)

USC researchers close to identifying crucial gene for human cleft lip and palate

A group of researchers has found that three siblings born with cleft lip and palate share a common gene mutation associated with the birth defect. The gene intraflagellar transport 88 (IFT88) ensures …

Yang Chai (Photo courtesy of the Ostrow School of Dentistry of USC)

Research group awarded $12 million to establish tissue regeneration center

A research team called C-DOCTOR (Center for Dental, Oral and Craniofacial Tissue and Organ Regeneration), initiated by the Ostrow School of Dentistry of USC, is one step closer to developing products that …

Human skull with sutures (Public domain image courtesy of Gray's Anatomy)

USC researchers awarded $3.3 million NIDCR grant to find more effective treatment for common birth defect

It might surprise you to learn that your cranium is not one continuous smooth bone encasing your brain. It’s actually comprised of eight bones, separated by fibrous joints, to give your skull …

Yang Chai (Photo courtesy of the Ostrow School of Dentistry of USC)

USC Stem Cell researcher Yang Chai receives $2.1 million from the National Institute of Dental and Craniofacial Research

Yang Chai, associate dean of Research at the Ostrow School of Dentistry of USC, has just received $2.1 million to continue research that could one day allow scientists to use stem cells …

Yang Chai (Photo courtesy of the Ostrow School of Dentistry of USC)

Ostrow awarded NIDCR grant to establish tissue regeneration center

Tissue regeneration is about to become more fact than fiction, thanks to a $2 million grant that’s being divided among 10 research centers and universities, including the Ostrow School of Dentistry of …

USC graduate student Du Jiang (Photo by Cristy Lytal)

Tri-institutional Stem Cell Retreat brings together Broad centers from USC, UCLA and UCSF

Working alone, a scientist or university can only make so much progress in finding answers to basic questions or new treatments for diseases ranging from HIV to cancer to diabetes. That’s why …

Yang Chai, DDS, PhD