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The kidney contains macula densa cells, which orchestrate kidney regeneration.; featured image for To regenerate the kidney, please don’t pass the salt

To regenerate the kidney, please don’t pass the salt

USC study showing loss of salt and body fluid stimulates kidney regeneration in mice, suggests new therapeutic approach to chronic kidney disease. A loss of salt and body fluid can stimulate kidney …

Lab grown human nephron progenitor cells (Image by Biao Huang/Li Lab); featured image for USC-led study introduces a new and improved way to grow the cells that give rise to the kidney’s filtration system

USC-led study introduces a new and improved way to grow the cells that give rise to the kidney’s filtration system

In a new study published in Cell Stem Cell, USC scientists report significant progress in cultivating nephron progenitor cells (NPCs), the cells destined to form the kidney’s filtration system, the nephrons. NPCs …

Charles (Chuck) Murry (Photo by Gavin Sisk/ University of Washington); featured image for USC Stem Cell welcomes new leader, renowned physician-scientist Chuck Murry

USC Stem Cell welcomes new leader, renowned physician-scientist Chuck Murry

Charles (Chuck) Murry, MD, PhD, has been appointed as the next head of USC Stem Cell. In that capacity, he will be the chair of the Department of Stem Cell Biology and …

Kidney organoids with proximal tubules (Image by Jack Schnell/Lindström Lab); featured image for $3.95 million CIRM grant establishes USC ASCEND Center to make stem cell-derived  organ models accessible to all

$3.95 million CIRM grant establishes USC ASCEND Center to make stem cell-derived organ models accessible to all

To democratize access to lab-grown organ-like structures known as organoids and other advanced stem cell and transcriptomic technologies, USC will launch the CIRM ASCEND Center, dedicated to “Advancing Stem Cell Education and …

Building an Incubator for Medicine of the 21st Century; featured image for Building an Incubator for Medicine of the 21st Century

Building an Incubator for Medicine of the 21st Century

USC Stem Cell is pleased to introduce our new publication. We hope you’ll enjoy reflecting back on our history, while looking ahead to the transformative times to come. Read now at https://stemcell.keck.usc.edu/wp-content/themes/stemcell/incubator.

(Image courtesy of iStock); featured image for $2 million grant boosts technological advancements in cutting-edge cell therapy manufacturing facility

$2 million grant boosts technological advancements in cutting-edge cell therapy manufacturing facility

The Keck School of Medicine of USC has received $2 million from the California Institute of Regenerative Medicine (CIRM) to further augment its newly launched cGMP Laboratory, a state-of-the-art facility designed to …

Two of the genes—Gsta4 in red and Cyp4a14 in green—that are more active in female mouse kidneys (blue) (Image by Jing Liu/McMahon Lab); featured image for Why are male kidneys more vulnerable to disease than female kidneys? USC Stem Cell-led mouse study points to testosterone.

Why are male kidneys more vulnerable to disease than female kidneys? USC Stem Cell-led mouse study points to testosterone.

Female kidneys are known to be more resilient to disease and injury, but males need not despair. A new USC Stem Cell-led study published in Developmental Cell describes not only how sex …

From left, Fokion Glykofrydis, Nils Lindström, Leonardo Morsut, and Connor Fausto (Photo by Sergio Bianco); featured image for USC Stem Cell’s journey towards 1,000 mini-kidneys begins with $1 million from KidneyX

USC Stem Cell’s journey towards 1,000 mini-kidneys begins with $1 million from KidneyX

To help patients in need of transplants, artificial kidneys would have to function like their natural counterparts, but they wouldn’t necessarily have to look like them. With a new $1 million prize …

Laura Perin (left) and Stefano Da Sacco (Image courtesy of CHLA); featured image for Study offers new insights into how the most common kidney cancer starts in kids

Study offers new insights into how the most common kidney cancer starts in kids

Researchers at Children’s Hospital Los Angeles found new clues to how disruption of the early process of kidney formation may be linked to the development of Wilms tumor — also known as …

Berenice Benayoun (Photo by Charles Camarda); featured image for USC Professor Bérénice Benayoun receives grant to study menopause and ovarian aging

USC Professor Bérénice Benayoun receives grant to study menopause and ovarian aging

Bérénice Benayoun, assistant professor of gerontology at the USC Leonard Davis School, received a $200,000 grant from the Chan Zuckerberg Initiative (CZI). The funding will support Benayoun’s work in understanding the molecular …

Pinchas Cohen (Image courtesy of the USC Davis School of Gerontology); featured image for Pinchas Cohen named USC Distinguished Professor

Pinchas Cohen named USC Distinguished Professor

Pinchas Cohen, dean of the USC Leonard Davis School of Gerontology, has been named a Distinguished Professor, an honor that is granted to a select group of USC academics each year. “These …

The new lab’s collaborative structure promises to play a key role in the development of groundbreaking advancements in health care. (Photo/Steve Cohn); featured image for New USC/CHLA cGMP Lab opens to accelerate next-generation cell therapy

New USC/CHLA cGMP Lab opens to accelerate next-generation cell therapy

A new laboratory designed to advance early-stage research into lifesaving, commercially viable therapies was celebrated on the USC Health Sciences Campus Tuesday night. Housed at the USC Norris Comprehensive Cancer Center, the …

Left to right: Roger De Filippo, MD, Stefano Da Sacco, PhD, Laura Perin, PhD (Image courtesy of CHLA); featured image for Podocyte protectors: NIH awards CHLA’s GOFARR Laboratory additional grants to combat chronic childhood kidney disease

Podocyte protectors: NIH awards CHLA’s GOFARR Laboratory additional grants to combat chronic childhood kidney disease

In children with progressive chronic kidney disease (CKD), loss of kidney function is for the most part irreversible. “The glomerulus is where the kidney filters the blood,” says Laura Perin, PhD, co-Director …

Kuo-Chang (Ted) Tseng from the Crump Lab and Michelle Hung from the Ichida Lab enjoy a beachside brainstorm.; featured image for Scientists feel the sand between their toes at the retreat for USC’s stem cell department

Scientists feel the sand between their toes at the retreat for USC’s stem cell department

A pair of young scientists picked up a piece of driftwood and thoughtfully traced a series of letters in the wet sand of Ventura Beach. The word “microglia”—referring to the immune cells …

Left to right: Roger De Filippo, MD, Stefano Da Sacco, PhD, Laura Perin, PhD; featured image for Children’s Hospital Los Angeles receives NIH awards for research into combating childhood kidney failure

Children’s Hospital Los Angeles receives NIH awards for research into combating childhood kidney failure

In children with progressive chronic kidney disease (CKD), loss of kidney function is mostly irreversible. The GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology at Children’s Hospital Los Angeles …

nurse visits with a patient; featured image for USC and CHLA awarded $8 million to expand access to cell and gene therapy clinical trials

USC and CHLA awarded $8 million to expand access to cell and gene therapy clinical trials

The California Institute for Regenerative Medicine (CIRM), the state’s stem cell agency, has awarded a five-year, $8 million grant to the Keck School of Medicine of USC and Children’s Hospital Los Angeles (CHLA). …

Justin Ichida (left) and Zhongwei Li (Photos by Chris Shinn and courtesy of Zhongwei Li); featured image for USC Stem Cell scientists Justin Ichida and Zhongwei Li receive NIH Director’s Awards

USC Stem Cell scientists Justin Ichida and Zhongwei Li receive NIH Director’s Awards

It’s hard to obtain research funding for safe ideas, and it’s even harder to find funding for risky ones. But thanks to the National Institutes of Health (NIH) Director’s Awards, USC Stem …

A cell showing the enzyme BirA*G3, which tags the proteins of the "secretome" (Image courtesy of the McMahon Lab)

This mouse can’t keep a secret about the “secretome”

The “secretome” refers to proteins that are secreted by a cell, a tissue or an organism. In a new study published in Open Biology, USC Stem Cell scientist Andy McMahon and his …

Human cystic kidney organoid (Image by Cheng (Jack) Song/McMahon Lab); featured image for USC Stem Cell scientists use mini-kidney models to identify potential drugs for polycystic kidney disease

USC Stem Cell scientists use mini-kidney models to identify potential drugs for polycystic kidney disease

In a new study in Cell Stem Cell, scientists from the USC laboratory of Andy McMahon generated simple kidney-like structures called organoids, and used them to identify potential drugs to treat adult-onset …

Detail of brain from Mukund Iyer's first place winning entry (Image by Mukund Iyer)

Communicating science visually: Mukund Iyer, MaryAnne Achieng and Stephanie Chang win the 2022 Winter BioRender contest

For his graphic on immune cell function in the brain, Mukund Iyer took first place in the Winter 2021 BioRender Illustration competition for his schematic of breast cancer cells’ entry through the …