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Stem cell scientists reveal key differences in male, female kidney

USC researchers have completed a detailed deconstruction of the kidney, revealing for the first time an intimate portrait of sexual differences and more in the organ. The findings could benefit 37 million Americans suffering from kidney disease by helping to distinguish how it affects men and women differently. They can help doctors pinpoint genes linked …

At the heart of regeneration: Scientists reveal a new frontier in cardiac research

Story courtesy of Children’s Hospital Los Angeles One of the reasons coronary heart disease is so deadly is that fluid build-up and scarring can develop in the heart tissue. This prevents the heart from contracting properly, impacting its ability to supply the body with fresh blood. If scarring is extensive, heart failure can result. “We’re …

Development of brain metastasis is a complex process in which metastatic cells (green) overcome the protective effect of immune cells (red). (Image/Yu Lab, USC Stem Cell)

Research reveals why breast cancer spreads to the brain

USC researchers have determined how cancer cells target certain organs, which could help develop treatments to slow or stop the disease from spreading. Most cancers kill because tumor cells spread beyond the primary site to invade other organs. Now, a USC study of brain-invading breast cancer cells circulating in the blood reveals they have a …

Photo of Ebony Flowers

Ebony Flowers named Choi Family Postdoctoral Fellow at USC Stem Cell

For Ebony Flowers, a postdoctoral fellow in the USC Stem Cell laboratory of Min Yu, doing science is ultimately about helping patients. “The fact that Min Yu’s Lab is looking at actual human samples from breast cancer patients, and I’m looking to see how this process of metastasis occurs in humans is appealing. You can …

Broad CIRM Center

Request for Proposals: Broad Stem Cell Innovation Awards for Collaborative Research Teams

Computational Biology and Single Cell Approaches to Stem Cell Systems Computational Biology and Single Cell Approaches to Stem Cell SystemsThrough the generous support of the Eli and Edythe Broad Foundation, we are pleased to announce a new collaborative research initiative in Computational Biology and Single Cell Approaches to Stem Cell Systems. The goal of funding …

Breakthrough in testosterone-producing cells could lead to treatment for “low T”

USC researchers have successfully grown human, testosterone-producing cells in the lab, paving the way to someday treat low testosterone with personalized replacement cells. In Monday’s Proceedings of the National Academy of Sciences, scientists describe how they transformed stem cells into functioning Leydig cells — the cells in the testes that produce the male sex hormone. “Our …

Request for Proposals: Broad Clinical Research Fellows

A new gift from The Eli and Edythe Broad Foundation enabled renewal of the Eli and Edythe Broad Clinical Research Fellows at USC. We plan to fund up to three positions. The fellows must have completed their MD or MD/PhD training, currently be in their residency or fellowship program and hold a license to practice …

Baxter Foundation supports research in pediatric blindness, human brain development

The Donald E. and Delia B. Baxter Foundation is supporting researchers exploring the causes of pediatric blindness and intellectual disability research by granting $100,000 awards to two assistant professors at the Keck School of Medicine of USC: Giorgia Quadrato, PhD, and Aaron Nagiel, MD, PhD. Quadrato, assistant professor of stem cell biology and regenerative medicine at …

Lindsey Michaela Katie Joanna SELFIE

Meet six USC Stem Cell postdocs-turned-professors

Only 23 percent of biomedical PhD holders eventually land tenure-track faculty positions, according to a report by the National Institutes of Health Biomedical Research Workforce Working Group. Beating these odds, six postdoctoral trainees from USC’s Department of Stem Cell Biology and Regenerative Medicine recently landed coveted jobs as tenure-track assistant professors: Lori O’Brien at the …

tangled

USC scientists surmount big obstacle to reprogram cells

USC scientists have surmounted a big roadblock in regenerative medicine that has so far constrained the ability to use repurposed cells to treat diseases. The researchers figured out how to reprogram cells to switch their identity much more reliably than present capabilities. The technique uses enzymes to untangle reprogramming DNA somewhat similar to how a …

USC Stem Cell scientist Thomas Lozito looks to lizards in hopes of healing humans

Some students sell blood plasma to make extra cash during graduate school. Thomas Lozito, a new professor of orthopaedic surgery and stem cell biology and regenerative medicine at USC, sold poison dart frogs to ward off the impecunity of the PhD years. “When I was in high school and all the way up to graduate …

Frank Petrigliano

Frank Petrigliano named chief of USC Epstein Family Center for Sports Medicine

The USC Epstein Family Center for Sports Medicine at Keck Medicine of USC, which specializes in treating sports-related and recreational injuries affecting the shoulder, knee, hip and elbow, recently announced the appointment of Frank Petrigliano, MD, as the chief of the center and head team physician for the Los Angeles Kings hockey team. He also …

USC brings the world’s largest stem cell conference to Los Angeles

For the first time ever, the City of Los Angeles hosted the world’s largest stem cell conference. By choosing Los Angeles as the host city for this major annual meeting, the International Society for Stem Cell Research (ISSCR) acknowledged the city’s growing importance as a hub for the biosciences, as well as the world-class research …

USC public symposium illustrates how to move stem cells from Petri dish to patient

Have you ever wondered how a scientific discovery in the laboratory becomes a new medical treatment for patients in the hospital? At the public symposium “Bringing Stem Cells to Patients – Treating Age-Related Blindness,” students, families, patients and local community members gathered on the lawn outside of USC’s stem cell research center to learn about …

USC researchers receive $12.5 million grant for craniofacial research data-sharing endeavor

Nearly half of all birth defects involve the face and skull and, for the most part, scientists remain unclear as to why most occur. To better serve families at risk for these conditions, scientists need a comprehensive and systematic understanding of how the faces of healthy children form and what goes wrong to cause common …

Jean Rosenbaum

France-USA Stem Cell Symposium gathers la crème de la crème

Science was the common language at the first France-USA Stem Cell Symposium, held at the Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC. The event brought together over 100 stem cell scientists from France and the United States on the eve of the field’s largest annual conference—the International …

Min Yu (Photo by Chris Shinn)

USC Stem Cell scientist Min Yu brings curiosity and compassion to cancer research

In her new lab, Min Yu observed the eerie predictability of a line of human breast cancer cells. First in one mouse, then in many, the cells metastasized again and again to the same vital organ: the brain. Alarmed, Yu telephoned the oncologist who had collected the cells from a patient. Yu learned that the …

From babies to senior citizens, USC Stem Cell researcher Denis Evseenko is working for better outcomes

When Denis Evseenko was still a student at Novosibirsk State Medical University in southern Siberia, he began pondering the meaning of life. “I was reading a lot of philosophic things [saying that] everything is pointless because you will die,” he said. “And the only one thing that makes it not completely pointless is that you …

$10 million gift from Broad Foundation advances USC stem cell research on aging-associated disease

USC’s groundbreaking stem cell research and training programs have received a major boost thanks to a $10 million gift from the Eli and Edythe Broad Foundation. The donation is part of the foundation’s latest $30 million funding initiative to support its namesake Eli and Edythe Broad stem cell research centers at USC, UCLA and University …

USC Stem Cell junior faculty balance babies with biomedical research

Growing stem cells isn’t just something junior faculty do in the lab. Eight of the junior faculty in the Department of Stem Cell Biology and Regenerative Medicine recently welcomed new babies into their families—more than half of them within the past year. Here, our junior faculty parents share their joy and wisdom about balancing career …

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