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Dr. Crump uses zebrafish to understand how the cartilages and bones of our faces are patterned during development. His lab is discovering the local tissue-tissue interactions that control skeletal differentiation and morphogenesis in vivo, and also exploring novel ways of regenerating bone in adults.

Stories

Kidney organoid (Image by Tracy Tran/McMcMahon Lab)

USC’s stem cell scientists secure the dollars to fight disease

The price of progress is not only the energy and talent of stem cell scientists, but also the research dollars that support their discoveries. In recent months, faculty members have secured numerous …

From left, D'Juan Farmer and Gage Crump (Photo by Cristy Lytal)

Stem cell scientist D’Juan Farmer named inaugural Choi Family Postdoctoral Fellow at USC

D’Juan Farmer grew up in a neighborhood where attending college—let alone pursuing a PhD or postdoctoral training—was not the expectation. Now, he’s earned the inaugural Choi Family Postdoctoral Fellowship, which provides support …

Gage Crump

University honors Gage Crump and other faculty for mentorship

USC Stem Cell scientist Gage Crump is one of seven faculty members with ties to the Health Sciences Campus receiving USC Mentoring Awards. The awards recognize faculty who exemplify the best in …

Joanna Smeeton (Photo by Cristy Lytal)

Broad Fellow Joanna Smeeton fishes around for stem cell-based treatments for arthritis

USC Stem Cell scientist Joanna Smeeton knows what arthritis can do to people: she’s witnessed the annual exodus out of her native country of Canada during the winter months. As this year’s …

From left, Gage Crump, Jay R. Lieberman and Francesca Mariani (Photo by Cristy Lytal)

Bone defects inspire perfect union between surgeon-scientist and stem cell researchers at USC

As chair of the Department of Orthopaedic Surgery at the Keck School of Medicine of USC, Jay R. Lieberman regularly sees patients with bone defects too severe to heal. This unmet clinical …

Human skull with sutures (Public domain image courtesy of Gray's Anatomy)

USC researchers awarded $3.3 million NIDCR grant to find more effective treatment for common birth defect

It might surprise you to learn that your cranium is not one continuous smooth bone encasing your brain. It’s actually comprised of eight bones, separated by fibrous joints, to give your skull …

From left, Andy McMahon and Gage Crump (Photos by Phil Channing and the Crump Lab)

What I’m reading: Top picks from stem cell faculty members Andy McMahon and Gage Crump

Andy McMahon: Leigh Turner and Paul Knoepfler present a disturbing report in Cell Stem Cell on the growth of businesses marketing stem cell interventions in the US. Los Angeles is one “stem …

Adult zebrafish jaw joint (Image by Amjad Askary)

Arthritis originated in primordial fish

We all know someone affected by arthritis—as well as that old dog down the block. But according to a new study in eLife, arthritis is much more widespread in the animal kingdom …

Lindsey Barske (Photo by Cristy Lytal)

USC Stem Cell scientist Lindsey Barske wins NIH Pathway to Independence Award

Years ago, Lindsey Barske pulled on a pair of tall rubber boots and began a journey that led from her college research experience on the muddy Alaskan tundra to her current postdoctoral …

Ophir Klein, professor at the University of California, San Francisco, delivered the keynote address. (Photo by Cristy Lytal)

Next generation of stem cell scientists detail their research from head to toe

The Stem Cell and Developmental Biology Retreat was a total body experience — covering organ systems ranging from the brain to the skeleton, from the kidney to the heart. Held on May …

New ways to regenerate bone emerge from the adult zebrafish face. (Image by Sandeep Paul and Seth Ruffins)

USC Stem Cell researchers use zebrafish to understand the role of cartilage in bone repair

Scientists have long believed that the processes required for embryonic development are recapitulated during the regeneration of damaged body parts, such as fractured bones. In a new study published in Development, USC …

A three-day-old zebrafish head skeleton with newly differentiated cartilage cells (magenta) emerging from a pool of skeletal progenitor cells (green) (Image by Lindsey Barske)

USC study shows how skeletal stem cells form the blueprint of the face

Timing is everything when it comes to the development of the vertebrate face. In a new study published in PLoS Genetics, USC Stem Cell researcher Lindsey Barske from the laboratory of Gage …

The joint cells are the ones that are not outlined in black. (Image by Amjad Askary and Lindsey Mork/Crump Lab)

Iroquois genes make cartilage cells act “oh so immature”

Arthritis, the leading cause of disability in the U.S., involves the loss of a special type of cartilage cell lining the joints. In a study appearing on the cover of the latest …

Gage Crump gives USC undergraduates a stem cell primer. (Photo by Cristy Lytal)

USC undergraduates get a dose of stem cells in two new MEDS courses

Science fiction author Margaret Atwood has frequently stated that biotechnology itself is neutral. It is how people use it that is good or bad. In the new spring course MEDS 380 Stem …

From left, Lindsey Barske, Michael Patterson, Ang Li and Yuwei Li (Photos by Cristy Lytal)

USC postdocs win Doerr Stem Cell Challenge Grants

Just as there are times when two heads are better than one, there are times when two labs are better than one. Thanks to the new Doerr Stem Cell Challenge Grants, teams …

“Tin Woman” Michaela Patterson, a postdoctoral scholar in the lab of Henry Sucov, studies heart regeneration — with no help from the Wizard of Oz. (Photo by Cristy Lytal)

Halloween retreat showcases USC’s “scary smart” stem cell researchers

It was no tricks and all treats at the seventh annual retreat for the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, held at the university’s …

Gage Crump

New stem cell course brings together science and fiction

Video by Alric Devotta USC will be offering a new two-unit class next spring, MEDS 380 Stem Cells: Fact and Fiction, which will explore contemporary topics in stem cell biology and innovative …

Dissection of the larval zebrafish skeleton shows facial cartilage (blue) and bone (red) (Image courtesy of the Crump Lab)

USC researchers reveal how gene expression affects facial expressions

A person’s face is the first thing that others see, and much remains unknown about how it forms — or malforms — during early development. Recently, Chong Pyo Choe, a senior postdoctoral fellow working …

Neil Segil, PhD, (right) gets a glimpse into retinal regeneration. (Photo by Cristy Lytal)

USC stem cell PhD students present their blueprints for rebuilding the body

Video by Alric Devotta The students in the new PhD program in Development, Stem Cells, and Regenerative Medicine recently presented some ideas that would give Dr. Frankenstein a run for his money. …

Human skull with sutures (Public domain image courtesy of Gray's Anatomy)

USC, UCLA and UCSF put their heads together to find stem cell-based cures for craniofacial defects

One in every 2,000 babies is born with a skull that can’t grow normally. Various sections of these babies’ skulls are fused together at joints called sutures, constricting the developing brain and …

Gage Crump, PhD