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Scientists Qi-Long Ying and Austin Smith win the 2016 McEwen Award for Innovation

Video by Henry Liu Researchers Qi-Long Ying from USC and Austin Smith from the University of Cambridge have won the 2016 McEwen Award for Innovation, the highest honor bestowed by the International Society for Stem Cell Research (ISSCR). Supported by the McEwen Centre for Regenerative Medicine, the award recognizes groundbreaking stem cell discoveries that open …

Chang Stem Cell Engineering Facility brings gene editing to USC and beyond

Once the stuff of science fiction, genetic engineering is now offered on a fee-for-service basis at USC. On September 19, USC Stem Cell faculty and staff welcomed their supporters, the Chang and Choi families, and nearly 100 of their friends to celebrate the grand opening of the Chang Stem Cell Engineering Facility, located on the second …

“Million-dollar ideas” seminar

At a special seminar on February 24, USC Stem Cell Principal Investigators discussed their “million-dollar ideas” for creating new tools and technologies to usher in the era of regenerative medicine. They shared research plans for their new, three-year Tools and Technologies grants from the California Institute for Regenerative Medicine (CIRM).

Three USC researchers win $4.3 million in awards from California’s stem cell agency

Three scientists from Keck Medicine of USC have won grants exceeding $4.3 million from the California Institute for Regenerative Medicine (CIRM) for research that includes creating a temporary liver for patients, finding novel ways to treat immune disorders and blood diseases, and developing new animal models for heart failure, diabetes and neurodegenerative diseases. The grants, …

Halloween retreat showcases USC’s “scary smart” stem cell researchers

It was no tricks and all treats at the seventh annual retreat for the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, held at the university’s Davidson Conference Center on Halloween. Center Director Andy McMahon welcomed nearly 100 researchers and encouraged them to mingle and get to “know at …

A Retreat from everything but stem cells

It wasn’t the pristine 27-hole course that drew more than 120 stem cell researchers from USC and beyond to the Desert Princess Golf Resort near Palm Springs. It was the sixth annual retreat for the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, which took place on October 20­ …

USC researcher reveals how to better master stem cells’ fate

USC scientist Qi-Long Ying and a team of researchers have long been searching for biotech’s version of the fountain of youth — ways to encourage embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) to endlessly self-renew, or divide to produce more stem cells. In a pair of studies published in Nature Communications in September …

Businessman invests in stem cell research at USC

Chinese businessman Yong Chen has pledged $1 million to USC stem cell researcher Qi-Long Ying to support his future “eureka moments.” “When I talked to Mr. Chen, I told him that groundbreaking discoveries often come from unexpected directions,” said Ying, associate professor of stem cell biology and regenerative medicine at the Eli and Edythe Broad …

A special protein helps embryonic stem cells keep their options open

In the ongoing quest to understand how embryonic stem cells (ESCs) retain their ability to differentiate into virtually any kind of cell, USC faculty member Qi-Long Ying and a team of researchers have discovered a new clue. An August study published in The EMBO Journal reveals the important role of Tfcp2l1 — a transcription factor, …

A genetic catch-22 promotes and prevents liver cancer

Can the same gene prevent and promote cancer? When it comes to liver cancer, the gene that codes for P53, a protein found in humans and many other animals, involves this catch-22. In a pair of articles published in Oncogene and the Journal of Hepatology, USC faculty member Qi-Long Ying and a team of researchers …

Probing the power of stem cells

Piece by missing piece, scientists at the Keck School of Medicine of USC are deciphering the powerful gene regulatory circuit that maintains and controls the potential of embryonic stem cells (ESCs) to form any type of cell in the body. Recent findings by Provost Professor Andrew McMahon, director of the Eli and Edythe Broad Center …

An important factor identified in reprogramming

How is the stem cell state programmed? A new study in Qi-Long Ying’s group at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC highlights the role of Gbx2, a DNA-binding regulatory factor, in switching fibroblasts to induced pluripotent stem cells. The study is published online in Journal of Cell Science.

USC research listed among top breakthroughs of 2010

Groundbreaking research by Keck School of Medicine of USC researchers has been selected as one of Science magazine’s top 10 Breakthroughs of 2010. The study, Production of p53 gene knockout rats by homologous recombination in embryonic stem cells, marked the first time that “knockout” rats—animals genetically modified to lack one or more genes—had been generated …

USC researchers create first “knockout” rats using embryonic stem cell technology

Researchers at the Keck School of Medicine of the University of Southern California (USC) have, for the first time, generated “knockout” rats—animals that are genetically modified to lack one or more genes—through embryonic stem (ES) cell-based gene targeting. The long-awaited achievement provides scientists with a far more effective animal model to study a range of …

Qi-Long Ying, MD, PhD

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