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Dr. McMahon’s laboratory explores the mechanisms that maintain stem/progenitor cells and regulate their differentiation to mature cell types of different organ systems, particularly the kidney. By combining genetic and genomic approaches with high resolution imaging, his group is aiming to obtain a deeper understanding of stem cell biology and to develop novel therapeutic strategies for regenerative medicine.

Stories

kidney organoid

USC Stem Cell scientists make big progress in building mini-kidneys

A team of scientists at the Keck School of Medicine of USC has created what could be a key building block for assembling a synthetic kidney. In a new study in Nature …

Broad Directors with Broads at ISSCR 2019

Remembering Eli Broad

It is with great sadness that we learned of the passing of Eli Broad. Eli and Edythe’s philanthropy in the arts, science and education have been transformative. Eli approached philanthropy with an …

Robert E. Maxson

USC celebrates Robert E. Maxson’s lifetime of achievement and adventure

USC Emeritus Professor Robert E. Maxson has an understated explanation for why he’s flown so many planes, sailed so many boats, skied so many mountains, played so many guitars, taken so many …

Impromptu McMahon lab meeting

USC Stem Cell study identifies molecular “switch” that turns precursors into kidney cells

Kidney development is a balancing act between the self-renewal of stem and progenitor cells to maintain and expand their numbers, and the differentiation of these cells into more specialized cell types. In …

Dion Dickman, Megan McCain, and Justin Ichida

Scientists Justin Ichida and Dion Dickman: USC’s coolest tenured professors from Hawaii

Now that Justin Ichida and Dion Dickman are both tenured professors at USC, they no longer have to worry about who was the coolest kid in their elementary schools back in Honolulu. …

Tracy Tran

USC Stem Cell PhD student Tracy Tran: Celebrating the journey of a budding developmental biologist

As a child in Vietnam, Tracy Tran helped her family run a small business importing porcelain products from China and assumed she would follow in their footsteps. Neither of her parents had …

Happy 10th Anniversary, BCC!

Happy 10th anniversary to USC’s stem cell research center

On October 29, 2010, we opened the doors of the Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC. Today, on the 10th anniversary of the …

USC's stem cell research center

California’s biggest stem cell experiment: The impact of the stem cell ballot proposition at USC

In 2008, USC broke ground on an $80 million building dedicated solely to stem cell research and regenerative medicine. The plans called for a monolithic structure clad in black marble and reflective …

Remote learning

USC Stem Cell’s high school program Zooms ahead

In late February 2020, 10 local high school juniors gathered at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC for the first meeting of a …

SARS-CoV-2

USC Stem Cell scientists use “mini-lungs” and lung models to understand COVID-19

USC scientists are testing out experimental COVID-19 treatments on human “mini-lungs” and lung models, grown in the laboratory using stem cells. With names such as organoids and lung-chips, these simplified, lung-like structures …

Andy McMahon (Photo by Christina Gandolfo)

A Message from Director and Chair Andy McMahon

I hope that this message finds you safe and well. As we return to our labs, I thought this would be a good time to let you know about what has been …

Qi-Long Ying

Shanghai Cell Therapy Group launches collaboration with USC researcher to improve the ex vivo expansion of hematopoietic stem cells for clinical applications

Shanghai Cell Therapy Group (SHCell) recently entered into a six-year research collaborative project with Professor Qi-Long Ying from the University of Southern California (USC). Through the project, sponsored by $3.6 million from …

Andrew P. McMahon

USC Professor Andrew P. McMahon elected to the National Academy of Sciences

Andrew P. McMahon—who is the W.M. Keck Provost and University Professor in USC’s departments of Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine, and Biological Sciences at the …

Long Cai

The Broad Foundation brings together stem cell scientists, engineers and physicians at USC and beyond

Developing new stem cell therapies requires more than a solo biologist having a eureka moment alone in the lab. Real progress relies on collaborations between biologists, engineers and physicians. That’s why The …

In-Part Discover

USC finds new routes to industry engagement and funding

Story courtesy of In-Part Over the last year, Dr. Qing Liu-Michael, Program Director at USC Stem Cell and the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at …

In a detailed, cell-by-cell look into the kidney, USC researchers found marked differences between the sexes. (Image courtesy of the McMahon Lab)

Stem cell scientists reveal key differences in male, female kidney

USC researchers have completed a detailed deconstruction of the kidney, revealing for the first time an intimate portrait of sexual differences and more in the organ. The findings could benefit 37 million …

USC Stem Cell at the world's largest stem cell conference (Photo by Sergio Bianco)

USC brings the world’s largest stem cell conference to Los Angeles

For the first time ever, the City of Los Angeles hosted the world’s largest stem cell conference. By choosing Los Angeles as the host city for this major annual meeting, the International …

Jean Rosenbaum

France-USA Stem Cell Symposium gathers la crème de la crème

Science was the common language at the first France-USA Stem Cell Symposium, held at the Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC. The event …

The $10 million donation from the Eli and Edythe Broad Foundation will support the USC stem cell research center’s core facilities and training programs, enable recruitment and attract research funding. (Photo by Sam Comen)

$10 million gift from Broad Foundation advances USC stem cell research on aging-associated disease

USC’s groundbreaking stem cell research and training programs have received a major boost thanks to a $10 million gift from the Eli and Edythe Broad Foundation. The donation is part of the …

Embryonic stem cells that have differentiated into neurons (Image by In Kyoung Mah/Mariani Lab)

From restoring sight to reversing brain damage, USC stem cell researchers are making life-changing discoveries

If anyone has a clear vision of the power of stem cell cures, it’s Anna Kuehl. She suffered a retina-wrecking disease that cost her much of her sight before USC physicians surgically …

Andrew P. McMahon, PhD, FRS