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USC and CHLA awarded $8 million to expand access to cell and gene therapy clinical trials

The California Institute for Regenerative Medicine (CIRM), the state’s stem cell agency, has awarded a five-year, $8 million grant to the Keck School of Medicine of USC and Children’s Hospital Los Angeles (CHLA). …

A cell showing the enzyme BirA*G3, which tags the proteins of the "secretome" (Image courtesy of the McMahon Lab)

This mouse can’t keep a secret about the “secretome”

The “secretome” refers to proteins that are secreted by a cell, a tissue or an organism. In a new study published in Open Biology, USC Stem Cell scientist Andy McMahon and his …

A zebrafish showing the skeleton and jaw (magenta), the eye (green circle on the left), and gill-like pseudobranch and gills (green structures on the right). (Image by Mathi Thiruppathy/Crump Lab)

How did vertebrates first evolve jaws?

Five-hundred million years ago, it was relatively safe to go back in the water. That’s because creatures of the deep had not yet evolved jaws. In a new pair of studies in …

Rong Lu

USC faculty member Rong Lu: Providing insights into stem cell biology in the context of aging and disease

Rong Lu is an associate professor of stem cell biology and regenerative medicine, biomedical engineering, medicine, and gerontology at USC. She joins George Shannon, faculty member and host of the podcast “Lessons …

Clare Yarka (Photo courtesy of Clare Yarka)

Where are they now? Stem cell master’s program alumna Clare Yarka, a Scientist at Instil Bio

In this series of alumni profiles, we highlight graduates of USC’s master of science program in stem cell biology and regenerative medicine. Our accomplished alumni have pursued many different paths—ranging from a …

Detail of brain from Mukund Iyer's first place winning entry (Image by Mukund Iyer)

Communicating science visually: Mukund Iyer, MaryAnne Achieng and Stephanie Chang win the 2022 Winter BioRender contest

For his graphic on immune cell function in the brain, Mukund Iyer took first place in the Winter 2021 BioRender Illustration competition for his schematic of breast cancer cells’ entry through the …

Clockwise from top left, Miao Cui, Yulia Shwartz, Olena Zhulyn, and Kyle McCracken

Stem cell scientists explore the mysteries of regeneration at the Junior Faculty Candidate Seminar and Symposium

How can we regenerate tissues that are damaged, lost or diseased in the human body? This was the central question driving the four scientists who presented their research at the Junior Faculty …

Rong Lu

For USC Stem Cell faculty member Rong Lu, science is in her blood

When Rong Lu joined USC as an assistant professor of stem cell biology and regenerative medicine in 2014, she knew that earning tenure would figuratively require blood, sweat and tears. But after …

Leukemia cells

How alike are the cancer cells from a single patient?

Even within a single patient with cancer, there is a vast diversity of individual tumor cells, which display distinct behaviors related to growth, metastasis, and responses to chemotherapy. To carry out these …

Bell in the lab

Drug-like molecule points to novel strategies for cancer therapy

A decade ago, genome sequencing revealed a big surprise: about 50 percent of human cancers are linked to mutations in what are known as epigenetic regulators, which control the activity of genes. …

Impromptu McMahon lab meeting

USC Stem Cell: An incubator for medicine of the 21st century

Just over a decade ago, USC was a university with a few scattered stem cell biologists, and a vision for total transformation. The university was committed to designing a unique “incubator” for …

Illustration by Jonathan Haase

Cycles of a fasting-mimicking diet help mice live longer, healthier

While many diets have been studied for effectiveness in preventing obesity and heart disease in both mice and humans, research on the effects and benefits of short, periodic cycles of fasting on obesity and heart health are lacking. In a new USC study on the health effects of a low-calorie diet that mimics …

Bérénice Benayoun (Photo courtesy of the USC Davis School of Gerontology)

Bérénice Benayoun receives prestigious investigator-focused grant

The Maximizing Investigators’ Research Award directly supports scientists, providing stability, flexibility and more opportunities for breakthroughs. The National Institute of General Medical Sciences has awarded an R35 Maximizing Investigators’ Research Award (MIRA) …

(Image courtesy of iStock)

Top scientists and research institutions propose improvements to cell- and gene-based therapy development

Led by a USC cell and gene therapy researcher, an international coalition calls for more transparency and reproducibility in research and development of breakthrough treatments.   Scientists around the world are achieving significant …

Neutrophil

Study highlights differences in immune cell function between male and female mice

A new USC study of a common, yet poorly understood type of white blood cell reveals the human immune cell’s response to pathogens differs greatly by sex and by age.  In this mouse study, males proved much more susceptible to a condition called sepsis than females. However, the scientists also found that the female disease-defense system is …

3-D illustration of ciliated cells. (Image courtesy of iStock)

Could mapping tiny hairlike structures help treat lung illnesses?

With a $2.3 million NIH award, USC researchers will study how cilia behavior and structure impact their function, a key in improving diagnostics and treatments for lung illnesses like COVID-19. Cilia, microscopic …

Scott Fraser by Noe Montes

USC Professor Scott E. Fraser redefines impossible problems

USC Professor Scott E. Fraser is known for inventing new microscopes and other tools to observe living, developing embryos. But one of his lab’s most important pieces of technology filters coffee instead …

Megan McCain and family

USC Professor Megan McCain crafts an approach to tissue engineering

Megan McCain has always liked using her hands to create things, ranging from art projects to human heart cells that grow on silicon chips. “I’ve always loved building things and doing crafts, …

Bérénice Benayoun (Photo courtesy of the USC Davis School of Gerontology)

Bérénice Benayoun receives GSA Nathan Shock New Investigator Award

The Gerontological Society of America (GSA)—the nation’s largest interdisciplinary organization devoted to the field of aging—has chosen Assistant Professor Bérénice Benayoun of the USC Leonard Davis School of Gerontology as the 2021 …

Leonardo Morsut

USC Stem Cell scientist Leonardo Morsut awarded $2.5 million NIH grant to explore “synthetic” embryonic development

Whether in an earthworm or a human being, developmental processes are driven by complex networks of genetically-encoded signals that enable cells to take cues from each other and their environment. To begin …