Dr. McMahon’s laboratory explores the mechanisms that maintain stem/progenitor cells and regulate their differentiation to mature cell types of different organ systems, particularly the kidney. By combining genetic and genomic approaches with high resolution imaging, his group is aiming to obtain a deeper understanding of stem cell biology and to develop novel therapeutic strategies for regenerative medicine.

Stories

From left, Edward Crandall, chair of the Department of Medicine, presents a UKRO award to Andy McMahon, chair of the Department of Stem Cell Biology and Regenerative Medicine. (Photo courtesy of HSC Communications office); featured image for Four honored at UKRO benefit gala

Four honored at UKRO benefit gala

University Kidney Research Organization (UKRO) honored USC academic and scientific leaders at its sixth gala dinner March 18 at The Beverly Hilton, with 300 attendees. This group of vocal champions of kidney …

Embryonic day 15.5 mouse kidney next to a 15.5 week human fetal kidney with SIX2 (cyan) marking the nephron progenitors and cytokeratin (red) highlighting the collecting duct system. Nuclei are in blue. (Image by Lori O'Brien)

USC researchers discover a key difference between mouse and human kidney stem cells

The best laid plans of mice and men are a bit different — at least when it comes to kidney development. Compared to a mouse, a human has nearly 100 times more nephrons, …

From left, Hsiang-Ying (Sherry) Lee, Sergei Doulatov, Leonardo Morsut, Alexander Pollen and Joan Font-Burgada (Photo by Cristy Lytal); featured image for USC Stem Cell mini-symposium introduces next-generation researchers

USC Stem Cell mini-symposium introduces next-generation researchers

The next generation of scientists is turning to stem cells to advance our understanding of systems ranging from the blood to the brain, from the liver to the lungs. Six of these …

Andy McMahon (Photo by Phil Channing); featured image for UKRO benefit dinner to honor USC leaders

UKRO benefit dinner to honor USC leaders

University Kidney Research Organization (UKRO) will honor a stellar group of USC academic and scientific leaders at its sixth gala dinner on March 18 at The Beverly Hilton. This group of vocal …

Motor neurons derived from an ALS patient (Image courtesy of the Ichida Lab); featured image for USC announces winners of the Audrey E. Streedain Regenerative Medicine Initiative Awards

USC announces winners of the Audrey E. Streedain Regenerative Medicine Initiative Awards

Two collaborative teams within USC Stem Cell are developing new approaches that could eventually help patients with heart disease, frontotemporal dementia and amyotrophic lateral sclerosis (ALS). The teams are the winners of …

Arthur Toga of the USC Stevens Neuroimaging and Informatics Institute and USC Stem Cell’s Andrew McMahon check an agenda with Raymond Stevens of the Bridge Institute at USC Dornsife. (Photo by Steve Cohn); featured image for At Keck-Dornsife retreat, scientists share research

At Keck-Dornsife retreat, scientists share research

Seeking to strengthen partnerships between two of USC’s oldest schools, scientists from the Keck School of Medicine of USC and USC Dornsife College of Letters, Arts and Sciences recently gathered to discuss …

Albert Kim (Photo by Cristy Lytal); featured image for Postdoctoral fellow Albert Kim receives first Hearst Fellowship

Postdoctoral fellow Albert Kim receives first Hearst Fellowship

How do you turn stem cells into nephrons, the functional unit of the kidney? Albert D. Kim, a postdoctoral fellow in the laboratory of Andy McMahon, is exploring this question with support …

From right, Qi-Long Ying, director of the Chang Stem Cell Engineering Facility; Daniel Chang; Andy McMahon, director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC; and Cai Li Chang (Photo by Cristy Lytal); featured image for Chang Stem Cell Engineering Facility brings gene editing to USC and beyond

Chang Stem Cell Engineering Facility brings gene editing to USC and beyond

Once the stuff of science fiction, genetic engineering is now offered on a fee-for-service basis at USC. On September 19, USC Stem Cell faculty and staff welcomed their supporters, the Chang and …

Activation of Sox9 (green) in nuclei (blue) of proximal tubular epithelial cells (yellow) following acute nephron injury. Surviving SOX9+ cells proliferate (red) to repair the damaged nephron restoring renal function. (Image courtesy of Sanjeev Kumar, Jing Liu, Paul Pang, A. Michaela Krautzberger, Antoine Reginensi, Haruhiko Akiyama, Andreas Schedl, Benjamin D. Humphreys and Andrew P. McMahon); featured image for Gene summons “surviving cells on deck” to repair the acutely injured kidney

Gene summons “surviving cells on deck” to repair the acutely injured kidney

In the kidney, injured cells can be kicked into reparative mode by a gene called Sox9, according to a new paper published in Cell Reports. First author Sanjeev Kumar, a postdoctoral research …

UKRO board and USC researchers in attendance included, from left, Edward Crandall, newly hired Director Kenneth Hallows, Nuria M. Pastor-Soler, Alicia McDonough, Laura Perin, Vito Campese and Janos Peti-Peterdi.; featured image for USC/UKRO Kidney Research Center opening is held

USC/UKRO Kidney Research Center opening is held

Keck School of Medicine of USC researchers recently joined board members from the University Kidney Research Organization (UKRO) to celebrate the opening of the USC/UKRO Kidney Research Center in the Mudd Memorial …

Clockwise from top left: Andre Luis de Castro Abreu, Victoria Forte, Kathy Schall and Rodrigo Martínez Monedero (Photos by Cristy Lytal); featured image for USC Stem Cell selects inaugural Broad Clinical Research Fellows

USC Stem Cell selects inaugural Broad Clinical Research Fellows

This year, the Broad Clinical Research Fellowships are enabling physician-investigators to explore stem cell-based approaches related to four very different medical conditions: breast cancer, kidney disease, deafness and short bowel syndrome. Each …

Janos Peti-Peterdi with his mother and son in 2004 (Photo by Reka Peti-Peterdi); featured image for USC kidney researcher Janos Peti-Peterdi wins Young Investigator Award

USC kidney researcher Janos Peti-Peterdi wins Young Investigator Award

USC kidney researcher Janos Peti-Peterdi has been selected as the 2015 recipient of the ASN-AHA Young Investigator Award. Co-sponsored by the American Society of Nephrology (ASN) and the Council on the Kidney …

Richard N. Merkin (Photo courtesy of Richard N. Merkin); featured image for The Merkin Family Foundation establishes four assistant professorships in regenerative medicine at USC

The Merkin Family Foundation establishes four assistant professorships in regenerative medicine at USC

In the past two years, USC’s Department of Stem Cell Biology and Regenerative Medicine has welcomed six new assistant professors to its ranks — and more are on the horizon. Thanks to a …

Developing zebrafish skeleton showing a gene called Sox9 (green) in cartilage-producing cells. (Image by Xinjun He/McMahon Lab); featured image for USC Stem Cell researchers reveal a genetic blueprint for cartilage

USC Stem Cell researchers reveal a genetic blueprint for cartilage

Cartilage does a lot more than determine the shapes of people’s ears and noses. It also enables people to breathe and to form healthy bones — two processes essential to life. In …

Kidney (Image by Lisa Rutledge and Seth Ruffins); featured image for Engineering undergraduates focus on building a microscope for USC’s stem cell research center

Engineering undergraduates focus on building a microscope for USC’s stem cell research center

Previously, when Andy McMahon, head of USC Stem Cell, wanted a three-dimensional image of a kidney, he would ship the organ to Australia. Now, he can send the organ down the hall …

USC graduate student Du Jiang (Photo by Cristy Lytal); featured image for Tri-institutional Stem Cell Retreat brings together Broad centers from USC, UCLA and UCSF

Tri-institutional Stem Cell Retreat brings together Broad centers from USC, UCLA and UCSF

Working alone, a scientist or university can only make so much progress in finding answers to basic questions or new treatments for diseases ranging from HIV to cancer to diabetes. That’s why …

Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC (Photo by Chris Shinn); featured image for Take a tour of USC’s stem cell research center

Take a tour of USC’s stem cell research center

Video by Alric Devotta Director Andy McMahon leads a tour of the Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC.

From right, biotech professionals Andy McMahon, Steve Kay, Stephen Gruber, Ray Stevens and David Meyer (Photo by Gus Ruelas); featured image for USC summit marks rebirth of biotech era in Los Angeles

USC summit marks rebirth of biotech era in Los Angeles

Los Angeles city and county policymakers and educational institutions laid the groundwork for the region’s biotechnology strategy at a summit on the USC Health Sciences Campus. The Los Angeles Biotech Summit drew …

Fred H. Gage delivered a brainy keynote address. (Photo by Cristy Lytal); featured image for USC Stem Cell Symposium creates scientific synergy

USC Stem Cell Symposium creates scientific synergy

Provost Michael Quick convened the inaugural USC Stem Cell Symposium with a straightforward truth about the future of regenerative medicine: “it will take a dedicated community of scholars across the disciplines to …

Stem cells won the heart of clinical trial participant Fred Lesikar. (Photo by Cristy Lytal); featured image for USC hosts California stem cell agency’s tenth birthday bash

USC hosts California stem cell agency’s tenth birthday bash

Few 10 year olds have brought 10 potential medical treatments into clinical trials. The California Institute for Regenerative Medicine (CIRM), however, is a truly exceptional 10 year old. In 2004, the people …