Unraveling the mystery of pluripotency in embryonic stem cells

Dr. Wange Lu and Fan Gao (Photo courtesy of USC)
Dr. Wange Lu and the first author Fan Gao (Photo courtesy of USC)

Using advanced sequencing technology, USC Stem Cell faculty member Wange Lu, in collaboration with Kai Wang of the USC Zilkha Neurogenetics Institute, explores the mystery of pluripotency by mapping out the interaction between DNA elements using genetic loci of two important pluripotency genes, OCT4 and SOX2.

Their finding shows that chromosome elements can interact transiently and dynamically with long-range target regions on the same chromosome or a different chromosome.

The study is published in Scientific Reports.