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Neuronal specification is compromised in Zfp462 deleted cells. Immunofluorescence images of wildtype (WT) and Zfp462 deleted (Zfp462 KO) cells during neural differentiation. The neuronal lineage marker SOX1 is shown in green and the endodermal lineage marker FOXA2 is in magenta. Non-neural cells are detected during the neural differentiation of Zfp462 KO cells. © Bell Lab / NCB /IMBA.; featured image for Weiss-Kruszka syndrome and the failure to establish neuronal identity

Weiss-Kruszka syndrome and the failure to establish neuronal identity

Weiss-Kruszka syndrome is a rare neurodevelopmental disorder characterized by craniofacial anomalies, developmental delay, and autistic features. Researchers at the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences and the …

Thomas Lozito and Donald the crested gecko (Photo by Sergio Bianco); featured image for A Tale of tails: How reptile regeneration could help humans

A Tale of tails: How reptile regeneration could help humans

“I’ve always been interested in science and in lizards. I got my first pet lizard when I was around 4 years old, and it was love at first sight,” says Thomas Lozito, …

From left, Cheryl Mae Craft, Justin Ichida and Dean Carolyn Meltzer (Photo by Greg Grudt/ Steve Cohn); featured image for Justin Ichida honored as the inaugural John Douglas French Alzheimer’s Foundation Associate Professor of Stem Cell Biology and Regenerative Medicine at USC

Justin Ichida honored as the inaugural John Douglas French Alzheimer’s Foundation Associate Professor of Stem Cell Biology and Regenerative Medicine at USC

In March 2020, Justin Ichida, PhD, was appointed to a prestigious endowed professorship at Keck School of Medicine of USC through a generous philanthropic gift from the John Douglas French Alzheimer’s Foundation. …

Left to right: Roger De Filippo, MD, Stefano Da Sacco, PhD, Laura Perin, PhD (Image courtesy of CHLA); featured image for Podocyte protectors: NIH awards CHLA’s GOFARR Laboratory additional grants to combat chronic childhood kidney disease

Podocyte protectors: NIH awards CHLA’s GOFARR Laboratory additional grants to combat chronic childhood kidney disease

In children with progressive chronic kidney disease (CKD), loss of kidney function is for the most part irreversible. “The glomerulus is where the kidney filters the blood,” says Laura Perin, PhD, co-Director …

(Image courtesy of Getty Images); featured image for Method developed by Children’s Hospital Los Angeles researchers automates brain cell mapping

Method developed by Children’s Hospital Los Angeles researchers automates brain cell mapping

Neuroscience graduate students at Children’s Hospital Los Angeles have developed an automated method that could save time and work for laboratories around the country by streamlining the process of identifying and mapping …

Professor Justin Ichida leads a class for USC's stem cell master's students (Photo by Chris Shinn)

Scholarships change lives in USC’s stem cell master’s program: Five students’ stories

For one scholarship recipient in the master’s program in stem cell biology and regenerative medicine, USC is just close enough to his mother’s house to commute and save on rent. For another, …

(Photo courtesy of Megan Rexius-Hall); featured image for Saving lives: Heart attack on a chip

Saving lives: Heart attack on a chip

Megan McCain has always enjoyed building and fixing things. She also has long been fascinated by cells in the human body and how they work together to achieve important tasks, like how …

Kuo-Chang (Ted) Tseng from the Crump Lab and Michelle Hung from the Ichida Lab enjoy a beachside brainstorm.; featured image for Scientists feel the sand between their toes at the retreat for USC’s stem cell department

Scientists feel the sand between their toes at the retreat for USC’s stem cell department

A pair of young scientists picked up a piece of driftwood and thoughtfully traced a series of letters in the wet sand of Ventura Beach. The word “microglia”—referring to the immune cells …

cancerous cell; Image courtesy of the Ostrow School of Dentistry of USC; featured image for Mini organs pave the way for understanding gastroesophageal cancer

Mini organs pave the way for understanding gastroesophageal cancer

USC researcher Dechen Lin has created miniature organs — with the hope of fighting a rare type of cancer. CANCERS THAT IMPACT THE JUNCTION of the esophagus and the stomach are rare …

Jean Chen Shih’s areas of expertise include brain development, autism spectrum disorder and repurposing antidepressants for brain cancer and prostate cancer. (Photo/Courtesy of the USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences); featured image for Pioneering pharmacy professor learned early to work hard and help others

Pioneering pharmacy professor learned early to work hard and help others

Editor’s note: Title IX — the landmark legislation that prohibits sex discrimination in educational institutions that receive federal funding — was signed into law on June 23, 1972. In recognition of this anniversary, we’ll …

Left to right: Roger De Filippo, MD, Stefano Da Sacco, PhD, Laura Perin, PhD; featured image for Children’s Hospital Los Angeles receives NIH awards for research into combating childhood kidney failure

Children’s Hospital Los Angeles receives NIH awards for research into combating childhood kidney failure

In children with progressive chronic kidney disease (CKD), loss of kidney function is mostly irreversible. The GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology at Children’s Hospital Los Angeles …

nurse visits with a patient; featured image for USC and CHLA awarded $8 million to expand access to cell and gene therapy clinical trials

USC and CHLA awarded $8 million to expand access to cell and gene therapy clinical trials

The California Institute for Regenerative Medicine (CIRM), the state’s stem cell agency, has awarded a five-year, $8 million grant to the Keck School of Medicine of USC and Children’s Hospital Los Angeles (CHLA). …

USC VITERBI’S RECENTLY NAMED ALFRED E. MANN DEPARTMENT OF BIOMEDICAL ENGINEERING IS HOME TO 75 PRIMARY AND AFFILIATED FACULTY, DRIVING CUTTING-EDGE RESEARCH FROM BIOMEDICAL DEVICES TO NEURAL ENGINEERING TO MOLECULAR BIOENGINEERING.; featured image for $35 million gift: Era of the Alfred E. Mann Department of Biomedical Engineering begins

$35 million gift: Era of the Alfred E. Mann Department of Biomedical Engineering begins

In 1976, the United States celebrated its’ 200th birthday, and USC’s department of biomedical engineering was born. Nearly 50 years later, that department has a name: the Alfred E. Mann Department of …

Albert Almada; featured image for USC Stem Cell scientist Albert Almada receives a grant from the American Federation for Aging Research (AFAR) and Glenn Foundation for Medical Research

USC Stem Cell scientist Albert Almada receives a grant from the American Federation for Aging Research (AFAR) and Glenn Foundation for Medical Research

Most senior citizens don’t have bulging biceps. USC Stem Cell scientist Albert Almada is uncovering the reasons why with support from a $125,000 grant from the American Federation for Aging Research (AFAR) …

At the lab bench (Photo by Chris Shinn); featured image for Call for Applications: CIRM Training Fellowships in Stem Cell Biology and Tissue Regeneration at USC

Call for Applications: CIRM Training Fellowships in Stem Cell Biology and Tissue Regeneration at USC

We have several positions open for USC PhD students and postdocs who are conducting research related to developmental biology, stem cell biology, and/or regenerative medicine. Fellowships are open to all regardless of …

Tianli "Sheldon" Ding

USC stem cell master’s program alumnus Tianli “Sheldon” Ding: Science saved his life at 21, and now this Trojan is on a mission

If Tianli Ding needed any confirmation that he was on the right path in life, he got in the form of a diagnosis: leukemia. When Ding was an undergraduate in college, stem …

Justin Ichida (left) and Zhongwei Li (Photos by Chris Shinn and courtesy of Zhongwei Li); featured image for USC Stem Cell scientists Justin Ichida and Zhongwei Li receive NIH Director’s Awards

USC Stem Cell scientists Justin Ichida and Zhongwei Li receive NIH Director’s Awards

It’s hard to obtain research funding for safe ideas, and it’s even harder to find funding for risky ones. But thanks to the National Institutes of Health (NIH) Director’s Awards, USC Stem …

Students in the teaching lab at USC's stem cell research center (Photo by Chris Shinn)

USC COMPASS undergraduate program points the way to stem cell careers

To promote inclusive excellence in science, USC will be offering a new program for undergraduates from historically underrepresented backgrounds with an interest in studying stem cell biology and regenerative medicine. Known as …

fasting and breast cancer; featured image for Fasting-mimicking diet reduces signs of dementia in mice

Fasting-mimicking diet reduces signs of dementia in mice

Cycles of a diet that mimics fasting appear to reduce signs of Alzheimer’s in mice genetically engineered to develop the illness, according to a new USC Leonard Davis School of Gerontology-led study. …

The brain; featured image for Newly discovered protein connected to Alzheimer’s disease risk

Newly discovered protein connected to Alzheimer’s disease risk

A mutation in a newly discovered small protein is connected to a significant increase in the risk for Alzheimer’s disease, expanding the known gene targets for the disease and presenting a new …